Stevan R. Hubbard

Schrodinger (United States) — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

59h-index18.5kcitations181works0.72yr avg
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Research Topics

Protein Kinase Regulation and GTPase Signaling(33), Metabolism, Diabetes, and Cancer(22), Cytokine Signaling Pathways and Interactions(22), Enzyme Structure and Function(18), Protein Tyrosine Phosphatases(15)

Publications180 total

AJ1-11095, a potent and highly selective type-II JAK2 inhibitor, shows enhanced therapeutic efficacy as compared with type-I JAK2 inhibitor ruxolitinib in models of myeloproliferative neoplasms (MPNs)
Blood·2025Open Access
Structural Identification of Major Molecular Determinants for Phosphotyrosine Recognition in Tyrosine Kinases Reveals Tumour Promoting and Suppressive Functions
2025
Catalytic activities of wild‐type <i>C. elegans</i><scp>DAF</scp>‐2 kinase and dauer‐associated mutants
FEBS Journal·2024· 2 citedOpen Access
Biochemical characterization of the <i>Drosophila</i> insulin receptor kinase and longevity‐associated mutants
The FASEB Journal·2023· 2 citedOpen Access
New scaffolds for type II JAK2 inhibitors overcome the acquired G993A resistance mutation
Cell chemical biology·2023· 11 citedOpen Access
Structural basis of Janus kinase trans-activation
Cell Reports·2023· 43 citedOpen Access
Identification of Novel Small Molecule Ligands for JAK2 Pseudokinase Domain
Pharmaceuticals·2023· 16 citedOpen Access
Decision letter: Molecular basis for the role of disulfide-linked αCTs in the activation of insulin-like growth factor 1 receptor and insulin receptor
2022Open Access
Unlocking the secrets to Janus kinase activation
Science·2022· 5 cited
Increased resistance of SARS-CoV-2 Omicron variant to neutralization by vaccine-elicited and therapeutic antibodies
EBioMedicine·2022· 148 citedOpen Access
Increased resistance of SARS-CoV-2 Omicron Variant to Neutralization by Vaccine-Elicited and Therapeutic Antibodies
2021· 16 citedOpen Access
Decision letter: A molecular mechanism for the generation of ligand-dependent differential outputs by the epidermal growth factor receptor
2021Open Access
Mechanism of homodimeric cytokine receptor activation and dysregulation by oncogenic mutations
Science·2020· 181 citedOpen Access
KRAS4A directly regulates hexokinase 1
Nature·2019· 194 citedOpen Access
Mechanism of homodimeric cytokine receptor activation and dysregulation by oncogenic mutations
Zenodo (CERN European Organization for Nuclear Research)·2019Open Access
New Paradigms for the Mechanisms of Thrombopoietin Receptor Activation and Dysregulation By the JAK2V617F Mutation
Blood·2019· 1 cited
Repeat Visual Field Assessments for Patients with Normal Visual Field Tests at their Referring Optometric Practice
International Journal of Ophthalmology and Clinical Research·2019Open Access
Structural models of full-length JAK2 kinase
2019· 5 citedOpen Access
Correction: Crystal structure of the C-terminal four-helix bundle of the potassium channel KCa3.1
PLoS ONE·2018· 1 citedOpen Access
Janus kinase 2 activation mechanisms revealed by analysis of suppressing mutations
Journal of Allergy and Clinical Immunology·2018· 28 citedOpen Access
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Frequent Co-authors

Moosa Mohammadi(7), Joseph Schlessinger(7), Steven J. Burden(5), Olli Silvennoinen(5), Jeffrey H. Till(4), Wayne A. Hendrickson(4), W. Todd Miller(4), Daniela Ungureanu(4), Gerald McMahon(3), Li Sun(3), Cho Tang(3), Jinhua Wu(3), Thomas A. Neubert(3), Junjie Hu(3), David Ron(2), Lei Wei(2), Amy L. Stiegler(2), Peter T. Hallock(2), A.N. Plotnikov(2), Flora Tang(2)