Kerim Babaoglu

Merck & Co., Inc., Rahway, NJ, USA (United States) — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

22h-index3.1kcitations39works10.02yr avg
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Research Topics

Antibiotic Resistance in Bacteria(8), Computational Drug Discovery Methods(8), Biochemical and Molecular Research(7), HIV/AIDS drug development and treatment(6), Metabolism and Genetic Disorders(4)

Publications39 total

Cerastecin Inhibition of the Lipooligosaccharide Transporter MsbA to Combat <i>Acinetobacter baumannii</i>: From Screening Impurity to <i>In Vivo</i> Efficacy
Journal of Medicinal Chemistry·2024· 5 cited
Cerastecins inhibit membrane lipooligosaccharide transport in drug-resistant Acinetobacter baumannii
Nature Microbiology·2024· 15 cited
Characterization of potent RSV neutralizing antibodies isolated from human memory B cells and identification of diverse RSV/hMPV cross-neutralizing epitopes
mAbs·2019· 41 citedOpen Access
Structure-guided discovery of a novel, potent, and orally bioavailable 3,5-dimethylisoxazole aryl-benzimidazole BET bromodomain inhibitor
Bioorganic & Medicinal Chemistry·2018· 16 citedOpen Access
Examining the Feasibility of Using Free Energy Perturbation (FEP+) in Predicting Protein Stability
Journal of Chemical Information and Modeling·2017· 31 cited
Structural basis for selectivity and diversity in angiotensin II receptors
Nature·2017· 212 citedOpen Access
Investigation of orexin-2 selective receptor antagonists: Structural modifications resulting in dual orexin receptor antagonists
Bioorganic & Medicinal Chemistry Letters·2017· 8 citedOpen Access
XFEL structure of human angiotensin II type 2 receptor (Monoclinic form) in complex with compound 1 (N-benzyl-N-(2-ethyl-4-oxo-3-{[2'-(2H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl])
2017
Overview of Methods and Strategies for Conducting Virtual Small Molecule Screening
Current Protocols in Chemical Biology·2017· 59 cited
Synthesis and preliminary PET imaging studies of [18F]MK-6240: A radiotracer for imaging neurofibrillary tangles (NFTs) in Alzheimer's disease
2016
Discovery of 6-(Fluoro-<sup>18</sup><i>F</i>)-3-(1<i>H</i>-pyrrolo[2,3-<i>c</i>]pyridin-1-yl)isoquinolin-5-amine ([<sup>18</sup>F]-MK-6240): A Positron Emission Tomography (PET) Imaging Agent for Quantification of Neurofibrillary Tangles (NFTs)
Journal of Medicinal Chemistry·2016· 175 cited
Structure and ligand-binding mechanism of the human OX1 and OX2 orexin receptors
Nature Structural & Molecular Biology·2016· 147 cited
Discovery of an Oral Respiratory Syncytial Virus (RSV) Fusion Inhibitor (GS-5806) and Clinical Proof of Concept in a Human RSV Challenge Study
Journal of Medicinal Chemistry·2015· 121 cited
A Small-Molecule Inhibitor of Hepatitis C Virus Infectivity
Antimicrobial Agents and Chemotherapy·2013· 22 citedOpen Access
New Class of HIV-1 Integrase (IN) Inhibitors with a Dual Mode of Action
Journal of Biological Chemistry·2012· 159 citedOpen Access
The HIV-1 Reverse Transcriptase M184I Mutation Enhances the E138K-Associated Resistance to Rilpivirine and Decreases Viral Fitness
JAIDS Journal of Acquired Immune Deficiency Syndromes·2011· 86 cited
Design, Synthesis, Crystal Structures, and Antimicrobial Activity of Sulfonamide Boronic Acids as β-Lactamase Inhibitors
Journal of Medicinal Chemistry·2010· 67 citedOpen Access
Structural Studies of Pterin-Based Inhibitors of Dihydropteroate Synthase
Journal of Medicinal Chemistry·2009· 91 citedOpen Access
Affinities between the Binding Partners of the HIV-1 Integrase Dimer-Lens Epithelium-derived Growth Factor (IN Dimer-LEDGF) Complex
Journal of Biological Chemistry·2009· 45 citedOpen Access
Docking for fragment inhibitors of AmpC β-lactamase
Proceedings of the National Academy of Sciences·2009· 100 citedOpen Access
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Frequent Co-authors

Stephen W. White(7), Richard Lee(6), Brian K. Shoichet(6), Jianjun Qi(5), Andrii Ishchenko(4), Paul J. Coleman(4), E.B. Lansdon(4), B.K. Shoichet(4), S.M. Soisson(3), Victoria C. Jones(3), Michael McNeil(3), James H. Naismith(3), Magdeleine Hung(3), Jason W. Skudlarek(3), Tamara D. Cabalu(3), James Mulhearn(3), Kirk E. Hevener(2), Brian Y. Feng(2), Anton Simeonov(2), Ajit Jadhav(2)