Toni Cathomen

University of Freiburg — Germany

Biochemistry, Genetics and Molecular Biology · Life Sciences

52h-index11.7kcitations238works11.72yr avg
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Research Topics

CRISPR and Genetic Engineering(143), Virus-based gene therapy research(58), RNA Interference and Gene Delivery(48), CAR-T cell therapy research(47), Advanced biosensing and bioanalysis techniques(30)

Publications238 total

Clinical development of gene edited tacrolimus-resistant Treg (FKBP12 <sup>KO</sup> -Treg) to enable simultaneous immunosuppression and support of immune regulation
2025
Engineering with care: safety assessment platforms for CRISPR-modified natural killer cells
Frontiers in Immunology·2025· 1 citedOpen Access
Targeted inhibition of ELANE expression using adenine base editing to treat severe congenital neutropenia
Molecular Therapy — Methods & Clinical Development·2025Open Access
Base edited skin equivalents with clinical potential for ex vivo correction of recessive dystrophic epidermolysis bullosa
Molecular Therapy·2025· 1 cited
Prime editing as a promising therapeutic strategy for junctional epidermolysis bullosa
Molecular Therapy·2025Open Access
Repurposing base editors for targeted knock-in and simultaneous knockouts to generate multiplex-edited allogeneic CAR T cells with minimal translocations
2025Open Access
ID3-depleted human induced pluripotent stem cell–derived neural stem/progenitor cells promote neurorepair
Neural Regeneration Research·2025· 1 citedOpen Access
Engineering of Humanized PSMA-Directed CAR T Cells for Potent and Specific Elimination of Prostate Cancer Cells
Cells·2025· 2 citedOpen Access
Low-frequency genetic variants in GAK enhance Golgi function and protect against Parkinson’s disease
2025Open Access
Targeted gene editing and near-universal cDNA insertion of CYBA and CYBB as a treatment for chronic granulomatous disease
Nature Communications·2025Open Access
The hidden risks of CRISPR/Cas: structural variations and genome integrity
Nature Communications·2025· 14 citedOpen Access
Development of a Gene Editing Platform to Enhance CAR-T Therapy Through Inducible IL-15 Expression at the PD-1 Locus
2025Open Access
Off-target effects in CRISPR-Cas genome editing for human therapeutics: Progress and challenges
Molecular Therapy — Nucleic Acids·2025· 29 citedOpen Access
Sustained and specific multiplexed immune checkpoint modulation in CAR T cells induced by targeted epigenome editing
Molecular Therapy — Nucleic Acids·2025· 7 citedOpen Access
Senescence and inflammation are unintended adverse consequences of CRISPR-Cas9/AAV6-mediated gene editing in hematopoietic stem cells
Cell Reports Medicine·2025· 5 citedOpen Access
Donor insertion into <i>CX3CR1</i> allows epigenetic modulation of a constitutive promoter on hematopoietic stem cells and its activation upon myeloid differentiation
Nucleic Acids Research·2025· 2 citedOpen Access
From CRISPR screens to circuits: identifying key regulators in T cell activation and state transitions
Signal Transduction and Targeted Therapy·2025· 1 citedOpen Access
Targeting BCL11B in CAR-engineered lymphoid progenitors drives NK-like cell development with prolonged anti-leukemic activity
Molecular Therapy·2025· 1 citedOpen Access
Gene editing of CD3 epsilon to redirect regulatory T cells for adoptive T cell transfer
Molecular Therapy·2025· 8 citedOpen Access
Modulation of TCR stimulation and pifithrin-α improve the genomic safety profile of CRISPR-engineered human T cells
Cell Reports Medicine·2024· 2 citedOpen Access
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Frequent Co-authors

Claudio Mussolino(12), Tatjana I. Cornu(8), J. Keith Joung(6), Jamal Alzubi(5), Roberto Cattaneo(4), Eva-Maria Händel(4), Morgan L. Maeder(3), Stacey Thibodeau-Beganny(3), Felix Müller-Lerch(3), Matthew H. Porteus(3), Thomas J. Cradick(3), Stephen Alwin(3), Matthew D. Weitzman(3), Tobias Cantz(3), Regine Heilbronn(3), Andreas Gogol‐Döring(3), Robert Thimme(2), Peter Hasselblatt(2), Florian Emmerich(2), Maximilian Seidl(2)