Bernard J. Lavins

Ironwood Pharmaceuticals (United States) — United States

Medicine · Health Sciences

16h-index2.7kcitations63works0.02yr avg
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Research Topics

Gastrointestinal motility and disorders(50), Intestinal Malrotation and Obstruction Disorders(19), Congenital gastrointestinal and neural anomalies(14), Gastroesophageal reflux and treatments(13), Diabetes Treatment and Management(9)

Publications63 total

FIRST-IN-HUMAN SINGLE-ASCENDING-DOSE STUDY OF IW-1973, A NEW SOLUBLE GUANYLATE CYCLASE STIMULATOR
Journal of the American College of Cardiology·2016· 4 cited
IW-3718, a Novel Gastric-Retentive Bile Acid Sequestrant, Improved Symptoms of Refractory GERD in a Double-Blind, Placebo-Controlled Phase 2a Study
The American Journal of Gastroenterology·2015· 2 cited
Sustainability of Linaclotide Response in Chronic Idiopathic Constipation Patients: A Post-hoc Pooled Analysis of Two Phase 3 Trials
The American Journal of Gastroenterology·2015
Linaclotide in Chronic Idiopathic Constipation Patients with Moderate to Severe Abdominal Bloating: A Randomized, Controlled Trial
PLoS ONE·2015· 79 citedOpen Access
Comparison of adequate relief with symptom, global, and responder endpoints in linaclotide phase 3 trials in IBS‐C
United European Gastroenterology Journal·2014· 16 citedOpen Access
The impact of abdominal pain on global measures in patients with chronic idiopathic constipation, before and after treatment with linaclotide: a pooled analysis of two randomised, double‐blind, placebo‐controlled, phase 3 trials
Alimentary Pharmacology & Therapeutics·2014· 28 citedOpen Access
Linaclotide Efficacy on Dyspepsia Symptoms Using Nepean Dyspepsia Index (NDI) in a Phase 3B Trial of CIC Patients With Bloating
The American Journal of Gastroenterology·2014
Two Years on Linaclotide: Tolerability and Treatment Satisfaction in IBS-C Patients With and Without Diarrhea: Presidential Poster
The American Journal of Gastroenterology·2014· 3 cited
PWE-166 Is Response To Linaclotide After 4 Weeks Of Treatment Predictive Of 12-week Improvement?
Gut·2014· 1 citedOpen Access
Sa2008 Efficacy and Safety of Linaclotide in Chronic Idiopathic Constipation Patients With Abdominal Bloating: Phase 3b Trial Results
Gastroenterology·2014· 1 cited
Effect of Linaclotide on Severe Abdominal Symptoms in Patients With Irritable Bowel Syndrome With Constipation
Clinical Gastroenterology and Hepatology·2013· 96 cited
Linaclotide Inhibits Colonic Nociceptors and Relieves Abdominal Pain via Guanylate Cyclase-C and Extracellular Cyclic Guanosine 3′,5′-Monophosphate
Gastroenterology·2013· 285 citedOpen Access
PWE-026 Effects of 26 Weeks of Linaclotide Treatment on Adequate Relief and IBS Severity in Patients with Irritable Bowel Syndrome with Constipation (IBS-C)
Gut·2013Open Access
PWE-028 Significantly Improved Abdominal Pain (AP) with Linaclotide (LIN) vs Placebo (PBO) in Patients (PTS) with Irritable Bowel Syndrome (IBS) Regardless of Baseline Pain Severity in 2 Phase 3 Trials
Gut·2013Open Access
PWE-025 Assessing the Percent of Days Linaclotide Improved Abdominal Symptoms and Stool Frequency in Patients with Irritable Bowel Syndrome with Constipation (IBS-C): Pooled Analysis of 2 Phase 3 Trials
Gut·2013Open Access
PWE-029 Characterisation and Association of Abdominal Pain With Anxiety or Depression in Patients with Irritable Bowel Syndrome with Constipation (IBS-C)
Gut·2013Open Access
PWE-027 Mediation Analysis Supports a Direct Effect of Linaclotide (LIN) on Abdominal Pain (AP) Relief Independent of Constipation Improvement
Gut·2013Open Access
Su2033 Determining the Minimum Duration for Initial Treatment With Linaclotide in IBS-C Patients: Results From Pooled Phase 3 Trials
Gastroenterology·2013· 2 cited
Mo2054 Assessing Abdominal and Bowel Symptoms Using Adequate Relief Based Thresholds: Results From 2 Phase 3 Trials of Linaclotide in Patients With Irritable Bowel Syndrome With Constipation
Gastroenterology·2013· 2 citedOpen Access
Comorbidities in Patients With Irritable Bowel Syndrome With Constipation or Chronic Idiopathic Constipation: A Review of the Literature From the Past Decade
Postgraduate Medicine·2013· 67 cited
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Frequent Co-authors

Mark G. Currie(35), Steven J. Shiff(32), Jeffrey M. Johnston(31), Anthony Lembo(29), James E. MacDougall(29), Caroline B. Kurtz(28), Harvey Schneier(27), Xinwei D. Jia(10), Kelvin Shi(10), William D. Chey(8), Xinming Hao(8), Donald A. Fitch(7), Jeffrey Johnston(7), Satish S.C. Rao(5), Robyn T. Carson(5), James Shao(4), Mollie Baird(4), Eamonn M.M. Quigley(4), Lin Chang(4), Susan M. Fox(3)