Jeffrey M. Johnston

Ironwood Pharmaceuticals (United States) — United States

Medicine · Health Sciences

31h-index4.6kcitations105works0.02yr avg
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Research Topics

Gastrointestinal motility and disorders(57), Congenital gastrointestinal and neural anomalies(24), Gastroesophageal reflux and treatments(20), Intestinal Malrotation and Obstruction Disorders(14), Diabetes Treatment and Management(9)

Publications105 total

Safety and tolerability of linaclotide for the treatment of chronic idiopathic constipation and irritable bowel syndrome with constipation: pooled Phase 3 analysis
Expert Review of Gastroenterology & Hepatology·2019· 17 citedOpen Access
The Effect of Psyllium Husk on Intestinal Microbiota in Constipated Patients and Healthy Controls
International Journal of Molecular Sciences·2019· 199 citedOpen Access
Cover Image
Neurogastroenterology & Motility·2018· 1 citedOpen Access
High‐dose linaclotide is effective and safe in patients with chronic constipation: A phase III randomized, double‐blind, placebo‐controlled study with a long‐term open‐label extension study in Japan
Neurogastroenterology & Motility·2018· 46 citedOpen Access
A randomized controlled and long‐term linaclotide study of irritable bowel syndrome with constipation patients in Japan
Neurogastroenterology & Motility·2018· 35 citedOpen Access
Dose‐finding study of linaclotide in Japanese patients with chronic constipation: A phase <scp>II</scp> randomized, double‐blind, and placebo‐controlled study
Neurogastroenterology & Motility·2018· 18 citedOpen Access
Demonstration of differences in colonic volumes, transit, chyme consistency, and response to psyllium between healthy and constipated subjects using magnetic resonance imaging
Neurogastroenterology & Motility·2018· 77 citedOpen Access
Tu1638 - Reliabilty of, and Agreement Between, Rome III and Rome IV Irritable Bowel Syndrome (IBS) Subtyping by Means of Stool Diary
Gastroenterology·2018
Tu1627 - Linaclotide is Effective and Safe for Patients with Chronic Constipation in Japan: A Phase III Randomized, Double-Blind, Placebo-Controlled Study with a Long-Term Open-Label Extension Study
Gastroenterology·2018
Randomized, double‐blind, placebo‐controlled study vs data in the daily practice using linaclotide in patients with irritable bowel syndrome with constipation
Neurogastroenterology & Motility·2018· 2 cited
Linaclotide in irritable bowel syndrome with constipation: A Phase 3 randomized trial in China and other regions
Journal of Gastroenterology and Hepatology·2018· 78 cited
Determining an optimal dose of linaclotide for use in Japanese patients with irritable bowel syndrome with constipation: A phase II randomized, double‐blind, placebo‐controlled study
Neurogastroenterology & Motility·2017· 34 citedOpen Access
Response to Miner et al.
The American Journal of Gastroenterology·2017Open Access
Safety and Tolerability of Linaclotide for the Treatment of CIC and IBS-C: A Pooled Analysis of Phase 3-3b Placebo-Controlled Trials in North America: 2017 Presidential Poster Award
The American Journal of Gastroenterology·2017
Dose-Finding of Linaclotide for Patients with Chronic Constipation in Japan: A Phase II Randomized, Double-Blind, and Placebo-Controlled Study
Gastroenterology·2017
Linaclotide is Effective and Safe for Patients with Irritable Bowel Syndrome with Constipation in Japan: A Phase III Randomized, Double-Blind, and Placebo-Controlled and Long-Term Extension Study
Gastroenterology·2017· 2 citedOpen Access
Association of Chronic Constipation With Gastrointestinal Complications in Younger Patients
The American Journal of Gastroenterology·2015
Linaclotide in Chronic Idiopathic Constipation Patients with Moderate to Severe Abdominal Bloating: A Randomized, Controlled Trial
PLoS ONE·2015· 79 citedOpen Access
Comparison of adequate relief with symptom, global, and responder endpoints in linaclotide phase 3 trials in IBS‐C
United European Gastroenterology Journal·2014· 16 citedOpen Access
Impact of linaclotide treatment on work productivity and activity impairment in adults with irritable bowel syndrome with constipation: results from 2 randomized, double-blind, placebo-controlled phase 3 trials.
PubMed·2014· 25 citedOpen Access
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Frequent Co-authors

Mark G. Currie(20), Anthony Lembo(14), Caroline B. Kurtz(14), Steven J. Shiff(13), James E. MacDougall(13), Bernard J. Lavins(12), Harvey Schneier(7), Xinwei D. Jia(5), Donald A. Fitch(4), Susan M. Fox(4), Shin Fukudo(4), Hiroto Miwa(4), Atsushi Nakajima(4), Masanori Kosako(4), Hiraku Akiho(4), William D. Chey(3), James Shao(3), Satish S.C. Rao(3), Kelvin Shi(3), Brenda I. Jeglinski(3)