W. Ewan Hume

National Institute for Japanese Language and Linguistics — Japan

Biochemistry, Genetics and Molecular Biology · Life Sciences

13h-index850citations35works0.02yr avg
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Research Topics

Amino Acid Enzymes and Metabolism(6), Glioma Diagnosis and Treatment(4), Chronic Kidney Disease and Diabetes(4), Cancer, Hypoxia, and Metabolism(4), Epigenetics and DNA Methylation(3)

Publications35 total

In vitro evaluation of (S)-2-amino-3-[3-(2-18F-fluoroethoxy)-4-iodophenyl]-2-methylpropanoic acid (18F-FIMP) as a positron emission tomography probe for imaging amino acid transporters
EJNMMI Research·2023· 1 citedOpen Access
In vitro evaluation of (S)-2-amino-3-[3-(2-18F-fluoroethoxy)-4-iodophenyl]-2-methylpropanoic acid (18F-FIMP) as a positron emission tomography probe for imaging amino acid transporters
Research Square (Research Square)·2023Open Access
Comparison of [18F]FIMP, [11C]MET, and [18F]FDG PET for early-phase assessment of radiotherapy response
Scientific Reports·2023· 6 citedOpen Access
First-in-human assessment of the novel LAT1 targeting PET probe 18F-FIMP
Biochemical and Biophysical Research Communications·2022· 16 cited
18F-FIMP: a LAT1-specific PET probe for discrimination between tumor tissue and inflammation
Scientific Reports·2019· 32 citedOpen Access
[<sup>18</sup>F]AA-7: PET imaging in patients with suspected glioma.
Journal of Clinical Oncology·2015· 1 cited
[18F]AA-7: A novel PET tracer for imaging L-type amino acid transporter 1 (LAT1)-positive tumors
2015
Quantitative Evaluation of mMate1 Function Based on Minimally Invasive Measurement of Tissue Concentration Using PET with [11C]Metformin in Mouse
Pharmaceutical Research·2015· 39 cited
The synthesis and biodistribution of [11C]metformin as a PET probe to study hepatobiliary transport mediated by the multi-drug and toxin extrusion transporter 1 (MATE1) in vivo
Bioorganic & Medicinal Chemistry·2013· 37 citedOpen Access
CCDC 776717: Experimental Crystal Structure Determination
The Cambridge Structural Database·2011Open Access
The stereodivergent asymmetric synthesis of a range of 2-(1′-hydroxyalkyl)phenols
Tetrahedron·2010· 9 cited
Amelioration of Established Diabetic Nephropathy by Combined Treatment with SMP-534 (Antifibrotic Agent) and Losartan in &lt;i&gt;db/db&lt;/i&gt; Mice
Nephron Experimental Nephrology·2006· 16 cited
Enhanced Effect of Combined Treatment with SMP-534 (Antifibrotic Agent) and Losartan in Diabetic Nephropathy
American Journal of Nephrology·2006· 16 cited
SMP-534 ameliorates progression of glomerular fibrosis and urinary albumin in diabetic<i>db/db</i>mice
American Journal of Physiology-Renal Physiology·2005· 27 cited
Structure—Activity Relationships of the Oxindole Growth Hormone Secretagogues.
ChemInform·2005· 2 cited
SMP-534 inhibits TGF-β-induced ECM production in fibroblast cells and reduces mesangial matrix accumulation in experimental glomerulonephritis
American Journal of Physiology-Renal Physiology·2005· 24 cited
Structure–activity relationships of the oxindole growth hormone secretagogues
Bioorganic & Medicinal Chemistry Letters·2005· 136 citedOpen Access
A concise and regioselective synthesis of 6-iodo-4-trifluoromethylisatin, an intermediate in the synthesis of the novel, non-peptidyl growth hormone secretagogue SM-130686
Tetrahedron·2002· 12 cited
Oxindole Derivatives as Orally Active Potent Growth Hormone Secretagogues
Journal of Medicinal Chemistry·2001· 286 cited
ChemInform Abstract: Synthesis of Tricyclic Azakynurenic Acids as a New Class of NMDA‐ Glycine Antagonists Using Novel Stille Coupling Reaction.
ChemInform·1997
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Frequent Co-authors

Yasuyoshi Watanabe(9), Teruhisa Tokunaga(8), Ryu Nagata(8), Mutsuo Taiji(7), Satoshi Nozaki(7), Yuka Nakatani(7), Jun Nagamine(6), Yasuhiro Wada(5), Aya Mawatari(5), Hisashi Doi(5), Emi Hayashinaka(4), Eiji Sugaru(4), Tsutomu Nakagawa(4), Makoto Kitoh(4), Stephen G. Davies(4), Michiko Ono‐Kishino(3), Naohiro Tsuyuguchi(3), Austen D. Pimm(2), Blanda Stammen(2), Tomotaka Shingaki(2)