Sarah L. Wynia‐Smith

Medical College of Wisconsin — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

14h-index562citations29works8.32yr avg
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Research Topics

Protein Degradation and Inhibitors(11), Sirtuins and Resveratrol in Medicine(6), Peptidase Inhibition and Analysis(6), Nitric Oxide and Endothelin Effects(5), Multiple Myeloma Research and Treatments(4)

Publications29 total

Multivalent nucleosome scaffolding by bromodomain and extraterminal domain tandem bromodomains
Journal of Biological Chemistry·2025· 2 citedOpen Access
The TRIM33 Bromodomain Recognizes Histone Lysine Lactylation
ACS Chemical Biology·2024· 24 citedOpen Access
Inhibition of Sirtuin Deacylase Activity by Peroxynitrite
Biochemistry·2024· 6 citedOpen Access
Zinc-chelating BET bromodomain inhibitors equally target islet endocrine cell types
American Journal of Physiology-Regulatory, Integrative and Comparative Physiology·2024· 1 citedOpen Access
Identification of Protein Targets of <i>S</i>-Nitroso-Coenzyme A-Mediated <i>S</i>-Nitrosation Using Chemoproteomics
ACS Chemical Biology·2023· 1 citedOpen Access
N-terminal BET bromodomain inhibitors disrupt a BRD4-p65 interaction and reduce inducible nitric oxide synthase transcription in pancreatic β-cells
Frontiers in Endocrinology·2022· 14 citedOpen Access
Zinc‐Chelating BET Bromodomain Inhibitors Selectively Accumulate and Affect Gene Expression in Pancreatic β‐Cells
The FASEB Journal·2022
Sirtuin Oxidative Post-translational Modifications
Frontiers in Physiology·2021· 21 citedOpen Access
1258-P: Il-1ß-Induced Transcription of Nf-kB Target Genes Is Repressed by Bet Bromodomain Inhibitors in Pancreatic ß-Cells
Diabetes·2021
BET bromodomain inhibitors diminish IL‐1B‐induced transcription of NF‐κB target genes
The FASEB Journal·2021· 1 cited
BET Bromodomain Inhibition Results in the Conserved Upregulation of Sirtuin 1
The FASEB Journal·2021
Cysteine sulfenylation by CD36 signaling promotes arterial thrombosis in dyslipidemia
Blood Advances·2020· 37 citedOpen Access
2131-P: BET Bromodomain Inhibition Upregulates SIRT1 In Pancreatic ß-Cells
Diabetes·2020
2117-P: BET Bromodomain Inhibitors Mitigate Cytokine-Induced Transcription in ß-Cells via Inhibition of Nf-κB
Diabetes·2020
Human sirtuins are differentially sensitive to inhibition by nitrosating agents and other cysteine oxidants
Journal of Biological Chemistry·2020· 26 citedOpen Access
Covalent-Fragment Screening of BRD4 Identifies a Ligandable Site Orthogonal to the Acetyl-Lysine Binding Sites
ACS Chemical Biology·2020· 39 citedOpen Access
Protein Cysteine Sulfenylation By CD36-Dependent Reactive Oxygen Species Signaling Promotes Platelet Activation
Blood·2019· 1 cited
Regulation of human sirtuin deacylase activity by cellular oxidants
Free Radical Biology and Medicine·2018
Protein sulfenylation by oxidized lipid signaling promotes activation of platelets
Free Radical Biology and Medicine·2018
Comparative and integrative metabolomics reveal that S-nitrosation inhibits physiologically relevant metabolic enzymes
Journal of Biological Chemistry·2018· 23 citedOpen Access
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Frequent Co-authors

Brian C. Smith(26), Joshua Nord(7), Kelsey Kalous(6), Michael D. Olp(5), Rachel A. Jones(5), Daniel J. Sprague(4), Raymundo Nuñez(4), Michael A. Marletta(3), Moua Yang(3), Calvin Harberg(3), Kate S. Carroll(3), Jacek Zielonka(3), Roy L. Silverstein(3), John A. Corbett(3), Rachel Jones Lipinski(3), Gail A. Robertson(2), Eranthie Weerapana(2), Christopher G. Goetz(2), Steven B. Summers(2), Renan B. Ferreira(2)