Jun Chen

Institute of High Energy Physics — China

Neuroscience · Life Sciences

23h-index2.2kcitations49works3.72yr avg
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Research Topics

Ion Channels and Receptors(30), Neurobiology and Insect Physiology Research(13), Ion channel regulation and function(8), Phytochemicals and Antioxidant Activities(7), Postharvest Quality and Shelf Life Management(7)

Publications49 total

Enteric gliosis induced by TRPV4 alleviates intestinal excessive-motility through Ca2+ signaling
Neuropharmacology·2025
EGCG and DOX dual-drug-loaded enzyme-responsive nanovesicles boost mitochondrial-mediated ICD for improved immunotherapy
Frontiers in Pharmacology·2025· 2 citedOpen Access
Regulation of Protein Transport in Functionalized PET Nanopores
The Journal of Physical Chemistry B·2025· 2 citedOpen Access
Fab-Induced Stabilization of an Ion Channel Receptor Enables Mechanistic Characterization of Small-Molecule Therapeutics
Analytical Chemistry·2025· 2 citedOpen Access
<i>In vivo</i> Distribution and Metabolism of Calcium Phosphate Nanomaterials Based on Fluorescent Labeling with Rare Earth Europium Ions
Journal of Inorganic Materials·2025· 1 citedOpen Access
CircFUT8 Promotes Megakaryocyte Proplatelet Formation By Regulating Actin Cytoskeleton Reorganization
Blood·2024Open Access
Protective role of TRPV2 in synaptic plasticity through the ERK1/2-CREB-BDNF pathway in chronic unpredictable mild stress rats
Biochemical and Biophysical Research Communications·2024· 7 cited
Discovery of TRPA1 Antagonist <b>GDC-6599</b>: Derisking Preclinical Toxicity and Aldehyde Oxidase Metabolism with a Potential First-in-Class Therapy for Respiratory Disease
Journal of Medicinal Chemistry·2024· 19 citedOpen Access
Norepinephrine protects against cochlear outer hair cell damage and noise-induced hearing loss via α2A-adrenergic receptor
BMC Neuroscience·2024· 4 citedOpen Access
A new twist to increase ion flow
Nature Chemical Biology·2024
Inherent differences of small airway contraction and Ca2+ oscillations in airway smooth muscle cells between BALB/c and C57BL/6 mouse strains
Frontiers in Cell and Developmental Biology·2023· 11 citedOpen Access
Cryo-EM reveals an unprecedented binding site for NaV1.7 inhibitors enabling rational design of potent hybrid inhibitors
eLife·2023· 22 citedOpen Access
Author response: Cryo-EM reveals an unprecedented binding site for NaV1.7 inhibitors enabling rational design of potent hybrid inhibitors
2023Open Access
CryoEM reveals unprecedented binding site for Na <sub>V</sub> 1.7 inhibitors enabling rational design of potent hybrid inhibitors
2022Open Access
NCX1 coupled with TRPC1 to promote gastric cancer via Ca2+/AKT/β-catenin pathway
Oncogene·2022· 29 citedOpen Access
Capsaicin inhibits intestinal Cl- secretion and promotes Na+ absorption by blocking TRPV4 channels in healthy and colitic mice
Journal of Biological Chemistry·2022· 23 citedOpen Access
Beneficial effect of capsaicin via TRPV4/EDH signals on mesenteric arterioles of normal and colitis mice
Journal of Advanced Research·2021· 28 citedOpen Access
A Retrospective Look at the Impact of Binding Site Environment on the Optimization of TRPA1 Antagonists
ACS Medicinal Chemistry Letters·2021· 18 citedOpen Access
A TRPA1 inhibitor suppresses neurogenic inflammation and airway contraction for asthma treatment
The Journal of Experimental Medicine·2021· 127 citedOpen Access
A Non-covalent Ligand Reveals Biased Agonism of the TRPA1 Ion Channel
Neuron·2020· 89 citedOpen Access
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Frequent Co-authors

David H. Hackos(11), Matthew Volgraf(9), Connie R. Faltynek(7), Alexis Rohou(7), Jian Payandeh(7), Bruce R. Bianchi(6), Philip R. Kym(6), Tianbo Li(6), Christopher P. Arthur(6), Claudio Ciferri(6), Huifen Chen(6), Xufeng Zhang(5), Regina M. Reilly(5), Shannon D. Shields(5), Tania Chernov-Rogan(5), Elisia Villemure(5), Brian S. Safina(5), Robert B. Moreland(5), Rebecca M. Reese(4), Daniel G. Shore(4)