Zhen Cai

Wake Forest University — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

9h-index1.2kcitations11works6.02yr avg
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Research Topics

Metabolism, Diabetes, and Cancer(6), Cancer, Hypoxia, and Metabolism(5), Epigenetics and DNA Methylation(3), Mitochondrial Function and Pathology(2), Pancreatic function and diabetes(2)

Publications11 total

ALDH4A1 functions as an active component of the MPC complex maintaining mitochondrial pyruvate import for TCA cycle entry and tumour suppression
Nature Cell Biology·2025· 6 cited
NSUN2 is a glucose sensor suppressing cGAS/STING to maintain tumorigenesis and immunotherapy resistance
Cell Metabolism·2023· 179 citedOpen Access
BDSF Is a Degradation-Prone Quorum-Sensing Signal Detected by the Histidine Kinase RpfC of <i>Xanthomonas campestris</i> pv. <i>campestris</i>
Applied and Environmental Microbiology·2022· 14 citedOpen Access
Inositol serves as a natural inhibitor of mitochondrial fission by directly targeting AMPK
Molecular Cell·2021· 82 citedOpen Access
Author Correction: SETDB1-mediated methylation of Akt promotes its K63-linked ubiquitination and activation leading to tumorigenesis
Nature Cell Biology·2021· 4 citedOpen Access
AMPK signaling and its targeting in cancer progression and treatment
Seminars in Cancer Biology·2021· 235 citedOpen Access
Phosphorylation of PDHA by AMPK Drives TCA Cycle to Promote Cancer Metastasis
Molecular Cell·2020· 260 citedOpen Access
Identification of primordial germ cell-like cells as liver metastasis initiating cells in mouse tumour models
Cell Discovery·2020· 11 citedOpen Access
The synergistic effect of PFK15 with metformin exerts anti-myeloma activity via PFKFB3
Biochemical and Biophysical Research Communications·2019· 25 cited
SETDB1-mediated methylation of Akt promotes its K63-linked ubiquitination and activation leading to tumorigenesis
Nature Cell Biology·2019· 194 citedOpen Access
The critical role of AMPK in driving Akt activation under stress, tumorigenesis and drug resistance
Nature Communications·2018· 182 citedOpen Access

Frequent Co-authors

Hui‐Kuan Lin(8), Che-Chia Hsu(5), Guoxiang Jin(5), Fei Han(4), Guihua Wang(4), Weina Zhang(4), Bo‐Syong Pan(4), Chuan Xu(4), Tingjin Chen(4), Danni Peng(3), Xian Zhang(3), Chi‐Yun Wang(3), Rajesh Manne(3), Hongyu Li(3), Chien‐Feng Li(2), Chunfang Liu(2), Jie Long(2), Yuan Gao(2), Li Sun(2), Shun-Chin Yang(2)