Qihong Xu

Broad Institute — United States

Medicine · Health Sciences

18h-index3.1kcitations30works0.52yr avg
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Research Topics

Chronic Myeloid Leukemia Treatments(10), Chronic Lymphocytic Leukemia Research(6), Eosinophilic Disorders and Syndromes(5), Neuroscience and Neuropharmacology Research(2), RNA Interference and Gene Delivery(2)

Publications30 total

GPR34 regulation of disease-associated microglial states and responses to physiological stimuli
2025Open Access
Unveiling regulatory network of porcine oocyte IVM using integrated multi-omics
Livestock Science·2025· 1 cited
Novel Fluorescence-Based High-Throughput FLIPR Assay Utilizing Membrane-Tethered Genetic Calcium Sensors to Identify T-Type Calcium Channel Modulators
ACS Pharmacology & Translational Science·2022· 9 citedOpen Access
Abstract 1555: Enhanced HER2-dependent immune activation by margetuximab, an investigational Fc-engineered anti-HER2 mAb, supports combination with checkpoint blockade
Cancer Research·2021
Abstract 554: Tumor-antigen 5T4-dependent activation of the CD137 costimulatory pathway by bispecific 5T4 x CD137 x CD137 TRIDENT™ molecules
Cancer Research·2019· 1 cited
Functionally Biased D2R Antagonists: Targeting the β-Arrestin Pathway to Improve Antipsychotic Treatment
ACS Chemical Biology·2018· 31 cited
Multiplex quantitative assays indicate a need for reevaluating reported small-molecule TrkB agonists
Science Signaling·2017· 91 cited
Discovery of Brigatinib (AP26113), a Phosphine Oxide-Containing, Potent, Orally Active Inhibitor of Anaplastic Lymphoma Kinase
Journal of Medicinal Chemistry·2016· 393 citedOpen Access
Cases of twinning at the Joint Center for Structural Genomics
Acta Crystallographica Section A Foundations of Crystallography·2011Open Access
Community nominated projects at the Joint Center for Structural Genomics
Acta Crystallographica Section A Foundations of Crystallography·2011Open Access
Discovery of 5-(arenethynyl) hetero-monocyclic derivatives as potent inhibitors of BCR–ABL including the T315I gatekeeper mutant
Bioorganic & Medicinal Chemistry Letters·2011· 18 citedOpen Access
Structural Mechanism of the Pan‐BCR‐ABL Inhibitor Ponatinib (AP24534): Lessons for Overcoming Kinase Inhibitor Resistance
Chemical Biology & Drug Design·2010· 282 cited
Discovery of 3-[2-(Imidazo[1,2-<i>b</i>]pyridazin-3-yl)ethynyl]-4-methyl-<i>N</i>-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}benzamide (AP24534), a Potent, Orally Active Pan-Inhibitor of Breakpoint Cluster Region-Abelson (BCR-ABL) Kinase Including the T315I Gatekeeper Mutant
Journal of Medicinal Chemistry·2010· 357 citedOpen Access
AP24534, a Pan-BCR-ABL Inhibitor for Chronic Myeloid Leukemia, Potently Inhibits the T315I Mutant and Overcomes Mutation-Based Resistance
Cancer Cell·2009· 1.2k citedOpen Access
9-(Arenethenyl)purines as Dual Src/Abl Kinase Inhibitors Targeting the Inactive Conformation: Design, Synthesis, and Biological Evaluation
Journal of Medicinal Chemistry·2009· 46 citedOpen Access
Abstract #3738: Discovery of potent and selective orally active inhibitors of anaplastic lymphoma kinase (ALK)
Cancer Research·2009· 11 cited
Potent Antitumor Activity of AP24534, An Orally Active Inhibitor of Bcr-Abl, Flt3 and Other Kinases, in Both in Vitro and in Vivo Models of Acute Myeloid Leukemia (AML)
Blood·2008· 8 cited
Novel N9-arenethenyl purines as potent dual Src/Abl tyrosine kinase inhibitors
Bioorganic & Medicinal Chemistry Letters·2008· 32 citedOpen Access
Potent Antitumor Activity of AP24534, an Orally Active Inhibitor of Bcr-Abl Variants Including T315I, in In Vitro and In Vivo Models of Chronic Myeloid Leukemia (CML).
Blood·2007· 21 cited
Crystal Structure of the T315I Mutant of Abl Kinase
Chemical Biology & Drug Design·2007· 103 citedOpen Access
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Frequent Co-authors

William C. Shakespeare(12), Tim Clackson(11), Xiaotian Zhu(10), Frank Wang(10), Scott Wardwell(10), David C. Dalgarno(10), Yaoyu Ning(9), Victor M. Rivera(8), Yihan Wang(7), J. T. Snodgrass(7), Wei‐Sheng Huang(7), Shuangying Liu(7), Jeffrey Keats(6), Raji Sundaramoorthi(6), Mathew Thomas(6), Tomi K. Sawyer(6), Jeff Keats(6), Karin Russian(6), Dong Zou(5), Lisi Cai(5)