Do Hoon Kwon

Arrien Pharmaceuticals (United States) — United States

Medicine · Health Sciences

19h-index1.7kcitations36works0.02yr avg
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Research Topics

Autophagy in Disease and Therapy(9), Ubiquitin and proteasome pathways(8), Ion Channels and Receptors(7), RNA and protein synthesis mechanisms(4), Enzyme Structure and Function(4)

Publications36 total

Abstract 5494: Pursuit of novel first-in-class medicines with a suite of AI-enabled platform technologies
Cancer Research·2025
Circular RNA circSmoc1-2 regulates vascular disease by acting as a miR-874-3p sponge
Atherosclerosis·2023Open Access
TRPV4-Rho GTPase complex structures reveal mechanisms of gating and disease
Nature Communications·2023· 72 citedOpen Access
MD simulations for "TRPV4-Rho GTPase complex structures reveal mechanisms of gating and disease"
Zenodo (CERN European Organization for Nuclear Research)·2023Open Access
Structural insights into TRPV4-Rho GTPase signaling complex function and disease
2023· 3 citedOpen Access
In vitro production of N-degron fused proteins and its application
Methods in enzymology on CD-ROM/Methods in enzymology·2023· 3 cited
Vanilloid-dependent TRPV1 opening trajectory from cryoEM ensemble analysis
Nature Communications·2022· 54 citedOpen Access
Structural insights into ClpP protease side exit pore‐opening by a pH drop coupled with substrate hydrolysis
The EMBO Journal·2022· 18 citedOpen Access
Opening the side exit pores of ClpP by lowering the pH of proteolytic chamber coupled with substrate hydrolysis
2021Open Access
Heat-dependent opening of TRPV1 in the presence of capsaicin
Nature Structural & Molecular Biology·2021· 220 citedOpen Access
Cryo-EM structure of full-length TRPV1 with capsaicin at 4 degrees Celsius
2021
Cryo-EM structure of full-length TRPV1 with capsaicin at 48 degrees Celsius, in an intermediate state, class 2
2021
Structural basis for the N‐degron specificity of <scp>ClpS1</scp> from <scp><i>Arabidopsis thaliana</i></scp>
Protein Science·2020· 19 citedOpen Access
Targeted Degradation of Transcription Coactivator SRC‐1 through the N‐Degron Pathway
Angewandte Chemie·2020· 2 cited
Targeted Degradation of Transcription Coactivator SRC‐1 through the N‐Degron Pathway
Angewandte Chemie International Edition·2020· 44 cited
Use of the LC3B-fusion technique for biochemical and structural studies of proteins involved in the N-degron pathway
Journal of Biological Chemistry·2020· 22 citedOpen Access
Structural studies of a novel ubiquitin-modifying enzyme, SdeA, using various tools
Acta Crystallographica Section A Foundations and Advances·2019Open Access
Endoribonucleolytic Cleavage of m6A-Containing RNAs by RNase P/MRP Complex
Molecular Cell·2019· 578 citedOpen Access
eIF4A3 Phosphorylation by CDKs Affects NMD during the Cell Cycle
Cell Reports·2019· 76 citedOpen Access
pH-dependent regulation of SQSTM1/p62 during autophagy
Autophagy·2018· 15 citedOpen Access
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Frequent Co-authors

Hyun Kyu Song(22), Leehyeon Kim(13), Seok‐Yong Lee(5), Byeong-Won Kim(5), Yang Suo(4), Jiwon Heo(4), Yoon Ki Kim(3), Feng Zhang(3), Jun Hoe Kim(3), Yang Ouk Jung(3), Brett A. McCray(3), Jeremy M. Sullivan(3), Charlotte J. Sumner(3), Bong Heon Kim(3), Min Kyung Kim(3), Ok Hyun Park(2), Hongseok Ha(2), Seung‐Beom Hong(2), Yeonkyoung Park(2), Shasha Feng(2)