William S. Chen

Biochemistry, Genetics and Molecular Biology · Life Sciences

12h-index3.7kcitations20works0.02yr avg
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Research Topics

Cancer Genomics and Diagnostics(5), Single-cell and spatial transcriptomics(5), Cell Image Analysis Techniques(4), Head and Neck Cancer Studies(3), Radiomics and Machine Learning in Medical Imaging(3)

Publications20 total

Supplementary Figures from Clinical and Genomic Implications of Luminal and Basal Subtypes Across Carcinomas
2023Open Access
Supplementary Figures from Clinical and Genomic Implications of Luminal and Basal Subtypes Across Carcinomas
2023Open Access
Uncovering axes of variation among single-cell cancer specimens
Nature Methods·2020· 58 citedOpen Access
Author Correction: Visualizing structure and transitions in high-dimensional biological data
Nature Biotechnology·2020· 12 citedOpen Access
Visualizing structure and transitions in high-dimensional biological data
Nature Biotechnology·2019· 1.1k citedOpen Access
Exploring single-cell data with deep multitasking neural networks
Nature Methods·2019· 346 citedOpen Access
CDKN2A Copy Number Loss Is an Independent Prognostic Factor in HPV-Negative Head and Neck Squamous Cell Carcinoma
Frontiers in Oncology·2018· 55 citedOpen Access
Visualizing Structure and Transitions for Biological Data Exploration
SSRN Electronic Journal·2018· 23 citedOpen Access
Exploring Single-Cell Data with Deep Multitasking Neural Networks
2017· 47 citedOpen Access
CDKN2A copy number loss in HPV- and HPV+ head and neck cancer to indicate poor prognosis: An integrated genomic and clinical TCGA analysis.
Journal of Clinical Oncology·2017· 2 cited
(S032) Investigating CDKN2A Copy Number Loss in HPV- and HPV+ Head and Neck Cancer: A Demonstration of Integrated Genomic and Clinical Analyses Using TCGA
International Journal of Radiation Oncology*Biology*Physics·2017Open Access
Radiation-Specific Clinical Data Should Be Included in Existing Large-Scale Genomic Datasets
International Journal of Radiation Oncology*Biology*Physics·2017· 4 cited
Akt1 governs breast cancer progression <i>in vivo</i>
Proceedings of the National Academy of Sciences·2007· 203 citedOpen Access
Akt deficiency impairs normal cell proliferation and suppresses oncogenesis in a p53-independent and mTORC1-dependent manner
Cancer Cell·2006· 233 citedOpen Access
Apoptosis in mouse embryos: Elevated levels in pregastrulae and in the distal anterior region of gastrulae of normal and mutant mice
Developmental Dynamics·1998· 59 citedOpen Access
The winged-helix transcription factor HNF-3β is required for notochord development in the mouse embryo
Cell·1994· 785 cited
Functional independence of the epidermal growth factor receptor from a domain required for ligand-induced internalization and calcium regulation
Cell·1989· 355 cited
Analysis of Functional Domains in the Epidermal Growth Factor Receptor Using Site-Directed Mutagenesis
Advances in experimental medicine and biology·1988· 5 cited
FACTOR RECEPTOR USING SITE-DIRECTED MUTAGENESIS
1988
Expression Cloning of Human EGF Receptor Complementary DNA: Gene Amplification and Three Related Messenger RNA Products in A431 Cells
Science·1984· 406 cited

Frequent Co-authors

David van Dijk(6), Guy Wolf(6), Smita Krishnaswamy(6), Kevin R. Moon(5), Gordon N. Gill(4), Michael G. Rosenfeld(4), James B. Yu(4), Daniel B. Burkhardt(3), Kristina Yim(3), Antonia van den Elzen(3), Matthew Hirn(3), Ronald R. Coifman(3), Natalia Ivanova(3), Cheri S. Lazar(3), Ranjit S. Bindra(3), Allen Mo(3), Thomas J. Hayman(3), Zain Husain(3), Joseph N. Contessa(3), Jeffrey P. Townsend(3)