Jianhua Shen

Nanjing University of Chinese Medicine — China

Computer Science · Physical Sciences

40h-index4.6kcitations137works8.12yr avg
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Research Topics

Computational Drug Discovery Methods(19), Drug Transport and Resistance Mechanisms(16), Peroxisome Proliferator-Activated Receptors(13), Diabetes Treatment and Management(12), Receptor Mechanisms and Signaling(11)

Publications137 total

Discovery of potent free fatty acid receptor 1 full agonists with a novel scaffold bearing conjugated double bond linker
Bioorganic & Medicinal Chemistry·2025
Property-Based Design of Xanthine Derivatives as Potent and Orally Available TRPC4/5 Inhibitors for Depression and Anxiety
Journal of Medicinal Chemistry·2025· 5 cited
Enrichment of Active Hydrogen at Amorphous CoO/Cu <sub>2</sub> O Heterojunction Interfaces Enhances Electrocatalytic Nitrate Reduction to Ammonia
Small·2024· 11 cited
In-situ preparation of BiOBr/Bi-doped CsPbBr3 S-scheme heterojunction for efficient photocatalytic CO2 reduction
Chemical Engineering Journal·2024· 30 cited
Decoupling Analysis of Ignition Processes of Ammonia/N-Heptane Mixtures
Energies·2024· 2 citedOpen Access
A novel approach to exploit Small-Molecule glucagon-like Peptide-1 receptor agonists with high potency
Bioorganic & Medicinal Chemistry·2024· 7 cited
In-Situ Preparation of Biobr/Bi-Doped Cspbbr3 S-Scheme Heterojunction for Efficient Photocatalytic Co2 Reduction
SSRN Electronic Journal·2024· 2 citedOpen Access
Discovery and exploration of novel somatostatin receptor subtype 5 (SSTR5) antagonists for the treatment of cholesterol gallstones
European Journal of Medicinal Chemistry·2023· 1 cited
Discovery of a novel GPR35 agonist with high and equipotent species potency for oral treatment of IBD
Bioorganic & Medicinal Chemistry·2023· 3 citedOpen Access
Discovery of Novel 5,6-Dihydro-1,2,4-triazine Derivatives as Efficacious Glucagon-Like Peptide-1 Receptor Agonists
Journal of Medicinal Chemistry·2023· 14 citedOpen Access
Magnesium lithospermate B ameliorates diabetic nephropathy by suppressing the uremic toxin formation mediated by gut microbiota
European Journal of Pharmacology·2023· 13 cited
TGR5 agonist inhibits intestinal epithelial cell apoptosis via cAMP/PKA/c-FLIP/JNK signaling pathway and ameliorates dextran sulfate sodium-induced ulcerative colitis
Acta Pharmacologica Sinica·2023· 40 citedOpen Access
Phenotypic screening-based drug discovery of furan-2-carboxylic acid derivatives for the amelioration of type 2 diabetes mellitus (T2DM)
European Journal of Medicinal Chemistry·2022· 3 cited
Coronarin A modulated hepatic glycogen synthesis and gluconeogenesis via inhibiting mTORC1/S6K1 signaling and ameliorated glucose homeostasis of diabetic mice
Acta Pharmacologica Sinica·2022· 11 citedOpen Access
Design and exploration of gut-restricted bifunctional molecule with TGR5 agonistic and DPP4 inhibitory effects for treating ulcerative colitis
European Journal of Medicinal Chemistry·2022· 7 citedOpen Access
Synthesis of AC1903 analogs as potent transient receptor potential canonical channel 4/5 inhibitors and biological evaluation
Bioorganic & Medicinal Chemistry·2022· 6 citedOpen Access
Discovery of pyrroledione analogs as potent transient receptor potential canonical channel 5 inhibitors
Bioorganic & Medicinal Chemistry Letters·2022· 6 citedOpen Access
Design and Exploration of Gut-Restricted Bifunctional Molecule with TGR5 Agonistic and DPP4 Inhibitory Effects for Treating Ulcerative Colitis
SSRN Electronic Journal·2022Open Access
Discovery of novel ketoxime ether derivatives with potent FXR agonistic activity, oral effectiveness and high liver/blood ratio
Bioorganic & Medicinal Chemistry·2021· 6 citedOpen Access
SL010110, a lead compound, inhibits gluconeogenesis via SIRT2-p300-mediated PEPCK1 degradation and improves glucose homeostasis in diabetic mice
Acta Pharmacologica Sinica·2021· 14 citedOpen Access
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Frequent Co-authors

Hualiang Jiang(31), Kaixian Chen(29), Xiaomin Luo(25), Weiliang Zhu(11), Yechun Xu(7), Hualiang Jiang(7), Chunshan Gui(6), Feng Cheng(6), Ruyun Ji(6), Hai‐Bin Luo(5), Xu Shen(5), Xiaojian Tan(5), Ying Leng(5), Xu Shen(4), Xu Shen(4), Suxin Zheng(4), Tao Sun(4), Mengmeng Ning(4), Meng Cui(4), Hong Liu(4)