Randolph M. Johnson

Portola Pharmaceuticals (United States) — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

23h-index3.0kcitations48works2.02yr avg
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Research Topics

Protein Kinase Regulation and GTPase Signaling(8), Nerve injury and regeneration(8), Neurogenesis and neuroplasticity mechanisms(5), Glioma Diagnosis and Treatment(3), Nitric Oxide and Endothelin Effects(3)

Publications48 total

ENPP1 inhibitor with ultralong drug-target residence time as an innate immune checkpoint blockade cancer therapy
Cell Reports Medicine·2025· 3 citedOpen Access
ENPP1 inhibitor with ultralong drug-target residence time as an innate immune checkpoint blockade cancer therapy
2025· 1 citedOpen Access
Pharmacokinetics Of Transbuccal Swab-Administered Naloxone-HCl Using A Novel Plant-Based Resin Formulation In Dogs
2020· 2 citedOpen Access
Comparison of AMG 416 and cinacalcet in rodent models of uremia
BMC Nephrology·2014· 25 citedOpen Access
Pharmacology of AMG 416 (Velcalcetide), a Novel Peptide Agonist of the Calcium-Sensing Receptor, for the Treatment of Secondary Hyperparathyroidism in Hemodialysis Patients
Journal of Pharmacology and Experimental Therapeutics·2013· 111 cited
Therapeutic Applications of Cell-Penetrating Peptides
Methods in molecular biology·2010· 109 cited
The polyamine analog PG11047 potentiates the antitumor activity of cisplatin and bevacizumab in preclinical models of lung and prostate cancer
Cancer Chemotherapy and Pharmacology·2009· 28 cited
Abstract #LB-205: PG11047, A Polyamine Analog, Induces Potent Antitumor Activity in a Preclinical Model of Non-Small Cell Lung Cancer in Combination with Cisplatin.
Cancer Research·2009
Intracranial drug-delivery scaffolds: Biocompatibility evaluation of sucrose acetate isobutyrate gels
Toxicology and Applied Pharmacology·2006· 26 cited
Polyamines, their biochemistry and role in neoplasia.
PubMed·2005· 2 cited
Toxicity and Cerebrospinal Fluid Levels of Carboplatin Chronically Infused into the Brainstem of a Primate
Journal of Neuro-Oncology·2004· 21 cited
A Surgical Technique for Safely Placing a Drug Delivery Catheter into the Pons of Primates: Preliminary Results of Carboplatin Infusion
Neurosurgery·2003· 1 cited
A Surgical Technique for Safely Placing a Drug Delivery Catheter into the Pons of Primates: Preliminary Results of Carboplatin Infusion
Neurosurgery·2003· 22 cited
Salicylate Induces Tinnitus through Activation of Cochlear NMDA Receptors
Journal of Neuroscience·2003· 308 citedOpen Access
Pharmacokinetic Advantage of Intrapericardially Applied Substances in the Rat
Journal of Pharmacology and Experimental Therapeutics·2002· 34 cited
Applications of continuous site-directed drug delivery.
PubMed·2002
Immortalized Human Dorsal Root Ganglion Cells Differentiate into Neurons with Nociceptive Properties
Journal of Neuroscience·1999· 58 citedOpen Access
Characterization of a promoter for the human glial cell line-derived neurotrophic factor gene
Molecular Brain Research·1999· 49 cited
Inhibition of Anandamide Hydrolysis by the Enantiomers of Ibuprofen, Ketorolac, and Flurbiprofen
Archives of Biochemistry and Biophysics·1999· 70 cited
Differential regulation of glial cell line-derived neurotrophic factor (GDNF) expression in human neuroblastoma and glioblastoma cell lines
Journal of Neuroscience Research·1999· 71 cited
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Frequent Co-authors

James C. Garrison(6), A. Neil Verity(4), Gregory R. Stewart(4), E Gillis(4), Benjamin S. Carson(4), Michael Guarnieri(4), Derek Maclean(3), Richard M. Eglen(3), Kathleen L. King(3), C.J. Emmett(3), Phillip B. Storm(3), David Fontana(2), Sarah Walter(2), Amos Baruch(2), Shawn T. Alexander(2), Julie Janes(2), Qun Yin(2), Dirk B. Mendel(2), Felix Karim(2), Patricia A. Connelly(2)