Derek Maclean

Southampton General Hospital — United Kingdom

Medicine · Health Sciences

35h-index3.8kcitations108works0.02yr avg
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Research Topics

Blood Pressure and Hypertension Studies(17), Thermal Regulation in Medicine(11), Chemical Synthesis and Analysis(9), Diabetes Treatment and Management(6), Pharmacology and Obesity Treatment(6)

Publications105 total

Identifying predictive markers for survival in malignant biliary obstruction following percutaneous transhepatic biliary drainage
Clinical Radiology·2024
P.063 Physician approaches to the initial management of an intraluminal thrombus in recently symptomatic carotid artery stenosis: results from the Hot Carotid Study
Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques·2023Open Access
P125 Evaluating an obstetrical anesthesia grant proposal generated by Artificial Intelligence (chatGPT)
International Journal of Obstetric Anesthesia·2023
Discovery of Etelcalcetide for the Treatment of Secondary Hyperparathyroidism in Patients with Chronic Kidney Disease
2019· 3 cited
Use of QSPR Modeling to Characterize In Vitro Binding of Drugs to a Gut-Restricted Polymer
Pharmaceutical Research·2018· 5 citedOpen Access
Polymers as drugs—Advances in therapeutic applications of polymer binding agents
Journal of Polymer Science Part A Polymer Chemistry·2017· 40 citedOpen Access
Critical Cysteine Residues in Both the Calcium-Sensing Receptor and the Allosteric Activator AMG 416 Underlie the Mechanism of Action
Molecular Pharmacology·2015· 82 cited
Comparison of AMG 416 and cinacalcet in rodent models of uremia
BMC Nephrology·2014· 25 citedOpen Access
Pharmacology of AMG 416 (Velcalcetide), a Novel Peptide Agonist of the Calcium-Sensing Receptor, for the Treatment of Secondary Hyperparathyroidism in Hemodialysis Patients
Journal of Pharmacology and Experimental Therapeutics·2013· 111 cited
KAI-4169, a Novel Calcimimetic for the Treatment of Secondary Hyperparathyroidism
2011· 1 cited
Therapeutic Applications of Cell-Penetrating Peptides
Methods in molecular biology·2010· 109 cited
Genotoxic Effects of Orthopaedic Wear Debris on the Bladder
British Journal of Medical and Surgical Urology·2010
Non-ATP-competitive kinase inhibitors – enhancing selectivity through new inhibition strategies
Expert Opinion on Drug Discovery·2008· 15 cited
Staff noise exposure during neonatal transportation
Paediatrics and Child Health·2007
Development of PKC Theta-Specific Inhibitors to Modulate T-Cell Activation (B35)
The Journal of Immunology·2007
Development of PKC Theta-Specific Inhibitors to Modulate T-Cell Activation
The Journal of Immunology·2007
Allosteric Activation of the Follicle-stimulating Hormone (FSH) Receptor by Selective, Nonpeptide Agonists
Journal of Biological Chemistry·2006· 84 citedOpen Access
The Representation of Combinatorial Libraries
ChemInform·2004
Agonists of the Follicle Stimulating Hormone Receptor from an Encoded Thiazolidinone Library
Journal of Combinatorial Chemistry·2003· 56 cited
On the Representation of Combinatorial Libraries
Journal of Combinatorial Chemistry·2003· 6 cited
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Frequent Co-authors

Peter R. Maroko(8), Michael C. Fishbein(4), Dennis J. McNamara(4), Tomi K. Sawyer(4), Christopher P. Holmes(4), Eric M. Gordon(4), Mark A. Gallop(4), Robert A. Kloner(4), Z.Y. Zhang(3), Andrea M. Thieme-Sefler(3), Eugene Braunwald(3), Sarah Walter(3), Amos Baruch(3), Shawn T. Alexander(3), Dirk B. Mendel(3), Randolph M. Johnson(3), Felix Karim(3), Zhi‐Jie Ni(3), Frank Holden(3), P. D. Griffiths(3)