Charles T. Esmon

Oklahoma Medical Research Foundation — United States

Medicine · Health Sciences

107h-index40.5kcitations389works7.02yr avg
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Research Topics

Blood Coagulation and Thrombosis Mechanisms(298), Venous Thromboembolism Diagnosis and Management(73), Coagulation, Bradykinin, Polyphosphates, and Angioedema(67), Vitamin K Research Studies(64), Venomous Animal Envenomation and Studies(49)

Publications389 total

Heme-induced loss of renovascular endothelial protein C receptor promotes chronic kidney disease in sickle mice
Blood·2024· 7 citedOpen Access
Expression of human thrombomodulin by GalTKO.hCD46 pigs modulates coagulation cascade activation by endothelial cells and during ex vivo lung perfusion with human blood
Xenotransplantation·2023· 9 citedOpen Access
Safety and efficacy of an anti–human APC antibody for prophylaxis of congenital factor deficiencies in preclinical models
Blood·2023· 14 citedOpen Access
Blocking human protein C anticoagulant activity improves clotting defects of hemophilia mice expressing human protein C
Blood Advances·2022· 14 citedOpen Access
Selective inhibition of activated protein C anticoagulant activity protects against hemophilic arthropathy in mice
Blood·2022· 22 citedOpen Access
Activated Protein C Strengthens Cardiac Tolerance to Ischemic Insults in Aging
Circulation Research·2021· 26 citedOpen Access
Thrombin spatial distribution determines protein C activation during hemostasis and thrombosis
Blood·2021· 17 citedOpen Access
An engineered activated factor V for the prevention and treatment of acute traumatic coagulopathy and bleeding in mice
Blood Advances·2021· 16 citedOpen Access
Localization of Phosphatidylserine Binding Sites to Structural Domains of Factor X a
UNC Libraries·2021Open Access
Lipid presentation by the protein C receptor links coagulation with autoimmunity
Science·2021· 114 citedOpen Access
Endothelial Cell Protein C Receptor Deficiency Attenuates <i>Streptococcus pneumoniae–</i> Induced Pleural Fibrosis
American Journal of Respiratory Cell and Molecular Biology·2021· 14 citedOpen Access
Factor VIIa induces extracellular vesicles from the endothelium: a potential mechanism for its hemostatic effect
Blood·2021· 40 citedOpen Access
Activated protein C has a regulatory role in factor VIII function
Blood·2021· 30 citedOpen Access
Different DOACs Control Inflammation in Cardiac Ischemia-Reperfusion Differently
Circulation Research·2020· 39 citedOpen Access
Aging Reprograms the Hematopoietic-Vascular Niche to Impede Regeneration and Promote Fibrosis
Cell Metabolism·2020· 79 cited
A critical role of endothelial cell protein C receptor in the intestinal homeostasis in experimental colitis
Scientific Reports·2020· 20 citedOpen Access
Role of Coagulation Factors in Cerebral Venous Sinus and Cerebral Microvascular Thrombosis
UNC Libraries·2020Open Access
Modeling Zymogen Protein C
UNC Libraries·2020Open Access
Podocyte Integrin-β 3 and Activated Protein C Coordinately Restrict RhoA Signaling and Ameliorate Diabetic Nephropathy
Journal of the American Society of Nephrology·2020· 26 citedOpen Access
Therapeutic doses of recombinant factor VIIa in hemophilia generates thrombin in platelet‐dependent and ‐independent mechanisms
Journal of Thrombosis and Haemostasis·2020· 9 citedOpen Access
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Frequent Co-authors

Fletcher B. Taylor(5), N L Esmon(5), Jun Xu(4), Naomi L. Esmon(4), Whyte G. Owen(4), Concetta T. Ammollo(3), Fabrizio Semeraro(3), Zoltán Lászik(3), Gary Ferrell(3), Deborah J. Stearns-Kurosawa(3), Shinichiro Kurosawa(3), Marc Monestier(2), George L. Dale(2), Marion S. Lockhart(2), P C Comp(2), Peter P. Nawroth(2), G Ferrell(2), Jean‐Louis Vincent(2), Mradul Kumar Daga(2), Mark Crowther(2)