Joseph W. Leone

Biochemistry, Genetics and Molecular Biology · Life Sciences

18h-index1.9kcitations43works0.02yr avg
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Research Topics

Glycosylation and Glycoproteins Research(7), Monoclonal and Polyclonal Antibodies Research(6), HIV Research and Treatment(5), HIV/AIDS drug development and treatment(5), Cell Adhesion Molecules Research(5)

Publications41 total

Silenced and Endangered: Clinicians' Human Rights and Health Concerns About Their Facilities' COVID-19 Response
2021· 1 cited
Evidence for cyclic diguanylate as a vaccine adjuvant with novel immunostimulatory activities
Cellular Immunology·2012· 60 cited
Removal of N‐Terminal Blocking Groups from Proteins
Current Protocols in Protein Science·2011· 6 cited
Structural and Thermodynamic Characterization of the TYK2 and JAK3 Kinase Domains in Complex with CP-690550 and CMP-6
Journal of Molecular Biology·2010· 224 cited
Expression, purification, and characterization of TYK-2 kinase domain, a member of the Janus kinase family
Biochemical and Biophysical Research Communications·2010· 5 cited
Expression, purification, characterization and crystallization of non- and phosphorylated states of JAK2 and JAK3 kinase domain
Protein Expression and Purification·2009· 20 cited
The ABRF Edman Sequencing Research Group 2008 Study: investigation into homopolymeric amino acid N-terminal sequence tags and their effects on automated Edman degradation
PubMed·2009· 6 citedOpen Access
ADAM‐8 isolated from human osteoarthritic chondrocytes cleaves fibronectin at Ala<sup>271</sup>
Arthritis & Rheumatism·2009· 49 cited
Purification and characterization of recombinant human soluble guanylate cyclase produced from baculovirus-infected insect cells
Protein Expression and Purification·2009· 4 cited
Autoactivation of human ADAM8: a novel pre-processing step is required for catalytic activity
Bioscience Reports·2008· 23 cited
High Yield Expression of Human BACE Constructs in Eschericia coli for Refolding, Purification, and High Resolution Diffracting Crystal Forms
Protein and Peptide Letters·2008· 15 cited
Large-Scale Purification of Human BACE Expressed in Mammalian Cells and Removal of the Prosegment with HIV-1 Protease to Improve Crystal Diffraction
Protein and Peptide Letters·2008· 6 cited
ABRF ESRG 2006 study: Edman sequencing as a method for polypeptide quantitation.
PubMed·2007· 10 cited
High Resolution Crystal Structure of the Catalytic Domain of ADAMTS-5 (Aggrecanase-2)
Journal of Biological Chemistry·2007· 78 citedOpen Access
Identification of an ADAMTS-4 Cleavage Motif Using Phage Display Leads to the Development of Fluorogenic Peptide Substrates and Reveals Matrilin-3 as a Novel Substrate
Journal of Biological Chemistry·2007· 44 citedOpen Access
ABRF ESRG 2005 Study: Identification of Seven Modified Amino Acids by Edman Sequencing
PubMed Central·2006· 6 citedOpen Access
An efficient method to express and refold a truncated human procaspase-9: A caspase with activity toward Glu-X bonds
Protein Expression and Purification·2005· 10 cited
Identification of a novel mitochondrial protein (“mitoNEET”) cross-linked specifically by a thiazolidinedione photoprobe
American Journal of Physiology-Endocrinology and Metabolism·2004· 339 cited
Employing a superior BACE1 cleavage sequence to probe cellular APP processing
Journal of Neurochemistry·2003· 53 cited
[W206R]-Procaspase 3: An Inactivatable Substrate for Caspase 8
Protein Expression and Purification·2001· 8 cited
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Frequent Co-authors

Alfredo G. Tomasselli(19), Robert L. Heinrikson(19), Thomas L. Emmons(9), June M. Lull(7), Heinz Fischer(7), Ana M. Mildner(7), Donna J. Paddock(7), Carol A. Bannow(5), Troii Hall(5), W. Rodney Mathews(4), Jacqueline E. Day(4), Timothy E. Benson(4), Richard G. Cook(4), Donna J. Rothrock(4), Jean L. Sarcich(4), D. Bryan Prince(4), Jill Chrencik(3), Robin A. Weinberg(3), Jennifer A. Gormley(3), Jennifer M. Williams(3)