Thomas L. Emmons

University of Colorado Hospital — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

15h-index1.1kcitations33works0.02yr avg
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Research Topics

Connexins and lens biology(12), Alzheimer's disease research and treatments(7), Protein Structure and Dynamics(5), Computational Drug Discovery Methods(4), Cytokine Signaling Pathways and Interactions(4)

Publications31 total

Preparedness in Perioperative Departments: Strategies for Effective Disaster Response
Journal of PeriAnesthesia Nursing·2025
Differential Kinetics and Inhibition of Purified Recombinant Tyrosine Kinase 2 (TYK-2) and Its Catalytic Domain JH-1
Protein and Peptide Letters·2012
Structural and Thermodynamic Characterization of the TYK2 and JAK3 Kinase Domains in Complex with CP-690550 and CMP-6
Journal of Molecular Biology·2010· 224 cited
Expression, purification, and characterization of TYK-2 kinase domain, a member of the Janus kinase family
Biochemical and Biophysical Research Communications·2010· 5 cited
Expression, purification, characterization and crystallization of non- and phosphorylated states of JAK2 and JAK3 kinase domain
Protein Expression and Purification·2009· 20 cited
Large Scale Refolding and Purification of the Catalytic Domain of Human BACE-2 Produced in E. coli
Protein and Peptide Letters·2009· 5 cited
Purification and characterization of recombinant human soluble guanylate cyclase produced from baculovirus-infected insect cells
Protein Expression and Purification·2009· 4 cited
The titerless infected-cells preservation and scale-up (TIPS) method for large-scale production of NO-sensitive human soluble guanylate cyclase (sGC) from insect cells infected with recombinant baculovirus
Protein Expression and Purification·2009· 105 cited
High yield purification of soluble guanylate cyclase from bovine lung
Protein Expression and Purification·2008· 4 cited
High Yield Expression of Human BACE Constructs in Eschericia coli for Refolding, Purification, and High Resolution Diffracting Crystal Forms
Protein and Peptide Letters·2008· 15 cited
Large-Scale Purification of Human BACE Expressed in Mammalian Cells and Removal of the Prosegment with HIV-1 Protease to Improve Crystal Diffraction
Protein and Peptide Letters·2008· 6 cited
Potent and selective isophthalamide S2 hydroxyethylamine inhibitors of BACE1
Bioorganic & Medicinal Chemistry Letters·2007· 41 citedOpen Access
Potent and selective isophthalamide S2 hydroxyethylamine inhibitor of BACE1
2007· 1 cited
Design, Synthesis, and Crystal Structure of Hydroxyethyl Secondary Amine-Based Peptidomimetic Inhibitors of Human β-Secretase
Journal of Medicinal Chemistry·2007· 110 citedOpen Access
Design of potent inhibitors of human β-secretase. Part 1
Bioorganic & Medicinal Chemistry Letters·2006· 32 cited
Design of potent inhibitors of human β-secretase. Part 2
Bioorganic & Medicinal Chemistry Letters·2006· 38 citedOpen Access
Electrophoretic mobility of Alzheimer’s amyloid-β peptides in urea–sodium dodecyl sulfate–polyacrylamide gel electrophoresis
Analytical Biochemistry·2003· 26 cited
Employing a superior BACE1 cleavage sequence to probe cellular APP processing
Journal of Neurochemistry·2003· 53 cited
Elevated Aβ levels in Alzheimer's disease brain are associated with selective accumulation of Aβ42 in parenchymal amyloid plaques and both Aβ40 and Aβ42 in cerebrovascular deposits
Amyloid·1995· 32 cited
The C-terminal region of <i>α</i>-crystallin: involvement in protection against heat-induced denaturation
Biochemical Journal·1993· 118 citedOpen Access
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Frequent Co-authors

Alfredo G. Tomasselli(15), L. Takemoto(11), D. Bryan Prince(9), Heinz Fischer(8), Timothy E. Benson(8), Donna J. Paddock(8), Joseph W. Leone(7), Michael J. Bienkowski(7), Robert L. Heinrikson(6), Jacqueline E. Day(5), Robin A. Weinberg(4), Jeffrey L. Hirsch(4), Joseph B. Moon(4), Jill Chrencik(3), Troii Hall(3), Jennifer A. Gormley(3), Cynthia D. Sommers(3), Joseph Horwitz(3), Karl J. Mathis(3), A. L. LABORDE(3)