Michael J. Bienkowski

Pfizer (United States) — United States

Medicine · Health Sciences

17h-index2.9kcitations28works0.02yr avg
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Research Topics

Alzheimer's disease research and treatments(7), Computational Drug Discovery Methods(5), Pharmacogenetics and Drug Metabolism(3), Inflammatory mediators and NSAID effects(3), Cholinesterase and Neurodegenerative Diseases(3)

Publications28 total

BACE Biological Assays
2010· 2 cited
Purification and characterization of recombinant human soluble guanylate cyclase produced from baculovirus-infected insect cells
Protein Expression and Purification·2009· 4 cited
The titerless infected-cells preservation and scale-up (TIPS) method for large-scale production of NO-sensitive human soluble guanylate cyclase (sGC) from insect cells infected with recombinant baculovirus
Protein Expression and Purification·2009· 105 cited
Potent and selective isophthalamide S2 hydroxyethylamine inhibitors of BACE1
Bioorganic & Medicinal Chemistry Letters·2007· 41 citedOpen Access
Design, Synthesis, and Crystal Structure of Hydroxyethyl Secondary Amine-Based Peptidomimetic Inhibitors of Human β-Secretase
Journal of Medicinal Chemistry·2007· 110 citedOpen Access
Design of potent inhibitors of human β-secretase. Part 1
Bioorganic & Medicinal Chemistry Letters·2006· 32 cited
Design of potent inhibitors of human β-secretase. Part 2
Bioorganic & Medicinal Chemistry Letters·2006· 38 citedOpen Access
Human β‐Secretase (BACE) and BACE Inhibitors.
ChemInform·2003· 1 cited
Human β-Secretase (BACE) and BACE Inhibitors
Journal of Medicinal Chemistry·2003· 146 citedOpen Access
Employing a superior BACE1 cleavage sequence to probe cellular APP processing
Journal of Neurochemistry·2003· 53 cited
BACE2 Functions as an Alternative α-Secretase in Cells
Journal of Biological Chemistry·2001· 176 citedOpen Access
Membrane-anchored aspartyl protease with Alzheimer's disease β-secretase activity
Nature·1999· 1.4k cited
Processing of the Human Heparanase Precursor and Evidence That the Active Enzyme Is a Heterodimer
Journal of Biological Chemistry·1999· 200 citedOpen Access
Localization of the ROMK protein on apical membranes of rat kidney nephron segments
American Journal of Physiology-Renal Physiology·1997· 192 cited
Nucleotide sequence analysis of the human KCNJ1 potassium channel locus
Gene·1997· 16 cited
Cloning and Characterization of Two K+ Inward Rectifier (Kir) 1.1 Potassium Channel Homologs from Human Kidney (Kir1.2 and Kir1.3)
Journal of Biological Chemistry·1997· 110 citedOpen Access
Activation of Human Eosinophils by Platelet-Derived Growth Factor
International Archives of Allergy and Immunology·1992· 23 cited
Pitfalls in the quantitative estimation of the secretion of granule proteins by eosinophils
Journal of Immunological Methods·1991· 16 cited
[58] Use of cultured cells to study arachidonic acid metabolism
Methods in enzymology on CD-ROM/Methods in enzymology·1990· 2 cited
Oligosaccharides Formed by Treatment of Heparin with Nitrous Acid*
Seminars in Thrombosis and Hemostasis·1985· 6 cited
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Frequent Co-authors

Alfredo G. Tomasselli(9), Thomas L. Emmons(7), Lawrence J. Marnett(6), Mary E. Shuck(5), Robert L. Heinrikson(5), Timothy E. Benson(4), Joseph B. Moon(4), D. Bryan Prince(4), Donna J. Paddock(4), Riqiang Yan(3), John R. Brashler(3), Joseph W. Leone(3), Jerry L. Slightom(3), Varghese John(3), Sukanto Sinha(3), A. L. LABORDE(3), W. Rodney Mathews(2), Clark W. Smith(2), Carol A. Bannow(2), James P. Beck(2)