Peter N. Walsh

Thrombosis Research Institute — United Kingdom

Medicine · Health Sciences

42h-index4.9kcitations128works0.02yr avg
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Research Topics

Blood Coagulation and Thrombosis Mechanisms(86), Coagulation, Bradykinin, Polyphosphates, and Angioedema(81), Hemophilia Treatment and Research(37), Platelet Disorders and Treatments(34), Protease and Inhibitor Mechanisms(16)

Publications126 total

Coagulation Factor XIa
Handbook of Proteolytic Enzymes·2012
The kunitz protease inhibitor domain of protease nexin-2 inhibits factor XIa and murine carotid artery and middle cerebral artery thrombosis
Blood·2012· 49 citedOpen Access
Productive Recognition of Factor IX by Factor XIa Exosites Requires Disulfide Linkage between Heavy and Light Chains of Factor XIa
Journal of Biological Chemistry·2011· 6 citedOpen Access
The Role of Factor XIa (FXIa) Catalytic Domain Exosite Residues in Substrate Catalysis and Inhibition by the Kunitz Protease Inhibitor Domain of Protease Nexin 2
Journal of Biological Chemistry·2011· 7 citedOpen Access
Localization of Ligand-Binding Exosites In the Catalytic Domain of Factor XIa.
Blood·2010
Conformational Changes Facilitate FXI Autoactivation to FXIa
Blood·2010· 3 cited
Structural and Mutational Analysis of Canonical Loop Residues In Protease Nexin 2 Involved In Factor XIa and Trypsin Inhibition.
Blood·2010
Determinants of Affinity and Proteolytic Stability in Interactions of Kunitz Family Protease Inhibitors with Mesotrypsin
Journal of Biological Chemistry·2010· 47 citedOpen Access
Mechanisms and specificity of factor XIa and trypsin inhibition by protease nexin 2 and basic pancreatic trypsin inhibitor
The Journal of Biochemistry·2010· 24 citedOpen Access
Platelets: yin and yang
Blood·2010· 5 citedOpen Access
The Amyloid Precursor Protein/Protease Nexin 2 Kunitz Inhibitor Domain Is a Highly Specific Substrate of Mesotrypsin
Journal of Biological Chemistry·2009· 42 citedOpen Access
Factor XI contributes to thrombin generation in the absence of factor XII
Blood·2009· 143 citedOpen Access
The Role of the P1 Residue of Protease Nexin 2 and Basic Pancreatic Trypsin Inhibitor in the Mechanism of Factor XIa Inhibition.
Blood·2008
Factor XI Homodimer Structure Is Essential for Normal Proteolytic Activation by Factor XIIa, Thrombin, and Factor XIa
Journal of Biological Chemistry·2008· 47 citedOpen Access
A Catalytic Domain Exosite (Cys<sup>527</sup>−Cys<sup>542</sup>) in Factor XIa Mediates Binding to a Site on Activated Platelets
Biochemistry·2007· 17 citedOpen Access
Factor XI Homodimer Formation Is Mediated by Electrostatic (Lys331 with Glu287) and Hydrophobic (Ile290 with Leu284 and Tyr329 with Tyr329) Interactions in the Apple 4 Domain and Is Essential for Normal Proteolytic Activation of Factor XI by Factor XIIa, Thrombin and Factor XIa.
Blood·2007
Structural Determinants for Heparin Binding in Human Coagulation Factor XI.
Blood·2007
Prothrombin Is a Cofactor for the Binding of Factor XI to the Platelet Surface and for Platelet-Mediated Factor-XI Activation by Thrombin
Biochemistry·2007· 9 cited
Solution structure of the A4 domain of factor XI sheds light on the mechanism of zymogen activation
Proceedings of the National Academy of Sciences·2007· 24 citedOpen Access
Retraction: Thrombin-mediated feedback activation of factor XI on the activated platelet surface is preferred over contact activation by factor XIIa or factor Xia. VOLUME 275 (2000) PAGES 20514-20519
Journal of Biological Chemistry·2007Open Access
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Frequent Co-authors

Frank A. Baglia(13), Karen O. Badellino(5), Duraiswamy Navaneetham(5), David H. Ho(5), David Gailani(4), Syed Sayeed Ahmad(4), Dipali Sinha(4), Mao-fu Sun(3), Steven Idell(3), José A. López(3), David C. B. Mills(2), Kathleen Gonzalez(2), Cassandra K. MacArthur(2), Alan M. Fein(2), Jerry McLarty(2), Robert W. Colman(2), Jonas Emsley(2), R Rawala-Sheikh(2), José A. López(2), Corie N. Shrimpton(2)