Chih‐Tai Leu

Medicine · Health Sciences

20h-index2.9kcitations31works0.02yr avg
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Research Topics

Cell Adhesion Molecules Research(9), Bone health and treatments(7), HIV/AIDS drug development and treatment(6), Inflammatory mediators and NSAID effects(6), HIV Research and Treatment(5)

Publications31 total

A Regulatory Circuit Mediating Convergence between Nurr1 Transcriptional Regulation and Wnt Signaling
Molecular and Cellular Biology·2014· 7 citedOpen Access
Discovery of the Selective Androgen Receptor Modulator MK-0773 Using a Rational Development Strategy Based on Differential Transcriptional Requirements for Androgenic Anabolism Versus Reproductive Physiology
Journal of Biological Chemistry·2010· 67 citedOpen Access
Design, Synthesis, and Biological Evaluation of 16-Substituted 4-Azasteroids as Tissue-Selective Androgen Receptor Modulators (SARMs)
Journal of Medicinal Chemistry·2009· 14 citedOpen Access
RETRACTED: A Regulatory Circuit Mediating Convergence between Nurr1 Transcriptional Regulation and Wnt Signaling
Molecular and Cellular Biology·2007· 57 citedOpen Access
Relative binding affinities of bisphosphonates for human bone and relationship to antiresorptive efficacy
Bone·2005· 149 cited
Nonpeptide α<sub>v</sub>β<sub>3</sub> Antagonists: Identification of Potent, Chain‐Shortened 7‐Oxo RGD Mimetics.
ChemInform·2005
Nonpeptide αvβ3 antagonists: identification of potent, chain-shortened 7-oxo RGD mimetics
Bioorganic & Medicinal Chemistry Letters·2005· 17 citedOpen Access
Nonpeptide α<sub>v</sub>β<sub>3</sub> Antagonists. Part 11:  Discovery and Preclinical Evaluation of Potent α<sub>v</sub>β<sub>3</sub> Antagonists for the Prevention and Treatment of Osteoporosis
Journal of Medicinal Chemistry·2004· 79 citedOpen Access
Nonpeptide αvβ3 antagonists. Part 10: In vitro and in vivo evaluation of a potent 7-methyl substituted tetrahydro-[1,8]naphthyridine derivative
Bioorganic & Medicinal Chemistry Letters·2004· 14 cited
Partial agonist/antagonist properties of androstenedione and 4-androsten-3β,17β-diol
The Journal of Steroid Biochemistry and Molecular Biology·2004· 52 cited
Nonpeptide αvβ3 antagonists. Part 9: Improved pharmacokinetic profile through the use of an aliphatic, des-amide backbone
Bioorganic & Medicinal Chemistry Letters·2004· 14 citedOpen Access
Non-peptide αvβ3 antagonists. Part 7: 3-Substituted tetrahydro-[1,8]naphthyridine derivatives
Bioorganic & Medicinal Chemistry Letters·2004· 22 citedOpen Access
Nonpeptide α<sub>v</sub>β<sub>3</sub> Antagonists. 8. In Vitro and in Vivo Evaluation of a Potent α<sub>v</sub>β<sub>3</sub> Antagonist for the Prevention and Treatment of Osteoporosis
Journal of Medicinal Chemistry·2003· 96 citedOpen Access
Non-Peptide αvβ3 antagonists. Part 6: Design and synthesis of αvβ3 antagonists containing a pyridone or pyrazinone central scaffold
Bioorganic & Medicinal Chemistry Letters·2003· 18 citedOpen Access
Binding Model for Nonpeptide Antagonists of α<sub>v</sub>β<sub>3</sub> Integrin
Journal of Medicinal Chemistry·2002· 48 citedOpen Access
Non-Peptide αvβ3 Antagonists. Part 4: Potent and Orally Bioavailable Chain-Shortened RGD Mimetics
Bioorganic & Medicinal Chemistry Letters·2002· 30 citedOpen Access
Prostaglandin Receptor EP4 Mediates the Bone Anabolic Effects of PGE2
Molecular Pharmacology·2001· 22 cited
Prostaglandin Receptor EP<sub>4</sub> Mediates the Bone Anabolic Effects of PGE<sub>2</sub>
Molecular Pharmacology·2001· 167 cited
Nonpeptide α<sub>v</sub>β<sub>3</sub> Antagonists. 1. Transformation of a Potent, Integrin-Selective α<sub>IIb</sub>β<sub>3</sub> Antagonist into a Potent α<sub>v</sub>β<sub>3</sub> Antagonist
Journal of Medicinal Chemistry·2000· 88 citedOpen Access
The Integrin Ligand Echistatin Prevents Bone Loss in Ovariectomized Mice and Rats
Endocrinology·1998· 121 cited
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Frequent Co-authors

Sevgi B. Rodan(15), Gideon A. Rodan(15), Mark E. Duggan(13), George D. Hartman(12), Thomayant Prueksaritanont(10), Le T. Duong(9), Carmen Fernández‐Metzler(8), John H. Hutchinson(7), Jill C. Heimbach(6), Paul L. Darke(6), Michael A. Gentile(6), Irving S. Sigal(5), Leonard P. Freedman(5), Donald B. Kimmel(5), Robert Meißner(5), Kara Merkle(5), Paula M.D. Fitzgerald(4), Brian M. McKeever(4), James P. Springer(4), Wasyl Halczenko(4)