David D. Hackney

Biochemistry, Genetics and Molecular Biology · Life Sciences

37h-index4.7kcitations81works0.02yr avg
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Research Topics

Microtubule and mitosis dynamics(47), Photosynthetic Processes and Mechanisms(23), Cellular transport and secretion(21), Mitochondrial Function and Pathology(12), Cardiomyopathy and Myosin Studies(12)

Publications81 total

The Kinesin-1 Family
2020· 3 cited
GTP hydrolysis promotes disassembly of the atlastin crossover dimer during ER fusion
The Journal of Cell Biology·2018· 13 citedOpen Access
The crossover conformational shift of the GTPase atlastin provides the energy driving ER fusion
The Journal of Cell Biology·2017· 17 citedOpen Access
Nucleotide-free kinesin motor domains reversibly convert to an inactive conformation with characteristics of a molten globule
Archives of Biochemistry and Biophysics·2016· 3 cited
Pi Release Limits the Intrinsic and RNA-Stimulated ATPase Cycles of DEAD-Box Protein 5 (Dbp5)
Journal of Molecular Biology·2015· 27 citedOpen Access
Structural Insights into a Unique Inhibitor Binding Pocket in Kinesin Spindle Protein
Journal of the American Chemical Society·2013· 57 cited
A Spacer between the Head and Neck Coil of Kinesin-1 Relieves Inhibition Due to Crosslinking of the Heads
Biophysical Journal·2013Open Access
Huntington-Associated Phosphorylation of Kinesin-1 Enhances Autoinhibition in a Phosphomimic
Biophysical Journal·2013· 3 citedOpen Access
Effect of an added spacer on the ‘double lockdown’ inhibition of kinesin‐1 by tail domains
The FASEB Journal·2012
Effect of Charge on Autoinhibition of Kinesin-1
Biophysical Journal·2012Open Access
Oxygen Isotopic Exchange Probes of ATP Hydrolysis by RNA Helicases
Methods in enzymology on CD-ROM/Methods in enzymology·2012· 2 cited
Half-Site Inhibition of Kinesin-1 by a Single Tail Domain, Sometimes One is Enough
Biophysical Journal·2012Open Access
The Structure of the Kinesin-1 Motor-Tail Complex Reveals the Mechanism of Autoinhibition
Science·2011· 205 citedOpen Access
Mechanism of Mss116 ATPase Reveals Functional Diversity of DEAD-Box Proteins
Journal of Molecular Biology·2011· 72 cited
When Is Weaker Better? Design of an ADP Sensor with Weak ADP Affinity, but Still Selective against ATP
ACS Chemical Biology·2010· 11 cited
Pathway of ATP utilization and duplex rRNA unwinding by the DEAD-box helicase, DbpA
Proceedings of the National Academy of Sciences·2010· 90 citedOpen Access
Coupling of Kinesin-1 Neck Linker Docking to the Nucleotide Binding Site
Biophysical Journal·2010Open Access
An allosteric transition trapped in an intermediate state of a new kinesin–inhibitor complex
Biochemical Journal·2009· 69 citedOpen Access
Intermediate and final states of human kinesin Eg5 in complex with S-trityl-L-cysteine
2009
Half-Site Inhibition of Dimeric Kinesin Head Domains by Monomeric Tail Domains
Biochemistry·2009· 56 cited
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Frequent Co-authors

Paul D. Boyer(7), Maryanne F. Stock(6), Frank Kozielski(5), Enrique M. De La Cruz(5), Wenxiang Cao(4), Arnon Henn(3), Dimitrios A. Skoufias(2), Salvatore DeBonis(2), Luc Lebeau(2), Isabelle Crevel(2), Robert A. Cross(2), Richard H. Wade(2), Hung Yi Kristal Kaan(2), Huang Tigang(2), Joelle D. Levitt(2), Joseph Suhan(2), Xun Li(2), Heidi Browning(2), Wei Jiang(2), Venkatasubramanian Ulaganathan(2)