Jean‐Marie Dupret

Centre National de la Recherche Scientifique — France

Biochemistry, Genetics and Molecular Biology · Life Sciences

30h-index2.9kcitations191works1.02yr avg
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Research Topics

Carcinogens and Genotoxicity Assessment(22), Polyamine Metabolism and Applications(21), Carbon Nanotubes in Composites(12), Mass Spectrometry Techniques and Applications(10), Epigenetics and DNA Methylation(9)

Publications191 total

Molecular and cellular effects of hydroxy-1,4 naphthoquinones used in dermatological and cosmetic applications on human protein tyrosine phosphatase PTP1B in human keratinocytes
Molecular Pharmacology·2025· 1 cited
Structural and enzymatic evidence for the methylation of the ACK1 tyrosine kinase by the histone lysine methyltransferase SETD2
Biochemical and Biophysical Research Communications·2023· 5 cited
Cisplatin causes covalent inhibition of protein-tyrosine phosphatase 1B (PTP1B) through reaction with its active site cysteine: Molecular, cellular and in vivo mice studies
Biomedicine & Pharmacotherapy·2022· 6 citedOpen Access
Human Protein Tyrosine Phosphatase 1B (PTP1B): From Structure to Clinical Inhibitor Perspectives
International Journal of Molecular Sciences·2022· 123 citedOpen Access
Biochemical, Enzymatic, and Computational Characterization of Recurrent Somatic Mutations of the Human Protein Tyrosine Phosphatase PTP1B in Primary Mediastinal B Cell Lymphoma
International Journal of Molecular Sciences·2022· 4 citedOpen Access
Carbon Black Nanoparticles Selectively Alter Follicle-Stimulating Hormone Expression in vitro and in vivo in Female Mice
Frontiers in Neuroscience·2021· 2 citedOpen Access
Structural characterization of a pathogenic mutant of human protein tyrosine phosphatase <scp>PTPN2</scp> (<scp>Cys216Gly</scp>) that causes very early onset autoimmune enteropathy
Protein Science·2021· 10 citedOpen Access
The Benzene Hematotoxic and Reactive Metabolite 1,4-Benzoquinone Impairs the Activity of the Histone Methyltransferase SET Domain Containing 2 (SETD2) and Causes Aberrant Histone H3 Lysine 36 Trimethylation (H3K36me3)
Molecular Pharmacology·2021· 11 citedOpen Access
Etoposide, an anticancer drug involved in therapy-related secondary leukemia: Enzymes at play
Translational Oncology·2021· 97 citedOpen Access
Human CREBBP acetyltransferase is impaired by etoposide quinone, an oxidative and leukemogenic metabolite of the anticancer drug etoposide through modification of redox-sensitive zinc-finger cysteine residues
Free Radical Biology and Medicine·2020· 13 citedOpen Access
From transglutaminases (TGs) to arylamine N-acetyltransferases (NATs): Insight into the role of a spatially conserved aromatic amino acid position in the active site of these two families of enzymes
Biochemical and Biophysical Research Communications·2020· 1 citedOpen Access
Benzoquinone, a leukemogenic metabolite of benzene, catalytically inhibits the protein tyrosine phosphatase PTPN2 and alters STAT1 signaling
Journal of Biological Chemistry·2019· 24 citedOpen Access
T-Cell Protein Tyrosine Phosphatase Is Irreversibly Inhibited by Etoposide-Quinone, a Reactive Metabolite of the Chemotherapy Drug Etoposide
Molecular Pharmacology·2019· 11 citedOpen Access
A readout of metabolic efficiency in arylamine <i>N</i>‐acetyltransferase‐deficient mice reveals minor energy metabolism changes
FEBS Letters·2019· 4 citedOpen Access
The Structure and the Regulation of Glycogen Phosphorylases in Brain
Advances in neurobiology·2019· 21 cited
Bacterial Arylamine <i>N</i>-Acetyltransferases: From Structures to Applications
WORLD SCIENTIFIC eBooks·2018· 1 cited
The H3K36 histone methyltransferase SETD2 as a target of leukemogenic chemicals: molecular and cellular studies.
The FASEB Journal·2018
Lack of estrogenic and anti-estrogenic activity of aromatic amines and their hydroxylated and acetylated metabolites on human breast cancer cells
Drug Metabolism and Pharmacokinetics·2018
Human Arylamine N-Acetyltransferase 1 Is Inhibited by the Dithiocarbamate Pesticide Thiram
Molecular Pharmacology·2017· 17 citedOpen Access
Molecular Mechanisms of Allosteric Inhibition of Brain Glycogen Phosphorylase by Neurotoxic Dithiocarbamate Chemicals
Journal of Biological Chemistry·2016· 15 citedOpen Access
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Frequent Co-authors

Fernando Rodrigues‐Lima(42), Julien Dairou(24), Edith Sim(6), Claudine Deloménie(6), Florent Busi(6), B. Pluvinage(6), Denis M. Grant(5), Marta Martins(5), Cécile Mathieu(4), Geoffrey H. GOODFELLOW(4), Noureddine Atmane(4), I. Li de la Sierra-Gallay(4), Romain Duval(4), Ximing Xu(4), Philippe Silar(4), Nilusha Ragunathan(4), Jérémy Berthelet(3), Sandrine Longuemaux(3), Christine Chomienne(3), Angélique Cocaign(3)