Kate Welsh

Biochemistry, Genetics and Molecular Biology · Life Sciences

35h-index6.5kcitations80works0.02yr avg
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Research Topics

Cell death mechanisms and regulation(46), Ubiquitin and proteasome pathways(12), interferon and immune responses(12), NF-κB Signaling Pathways(11), ATP Synthase and ATPases Research(11)

Publications80 total

Supplementary Figure 1 from Small-Molecule IAP Antagonists Sensitize Cancer Cells to TRAIL-Induced Apoptosis: Roles of XIAP and cIAPs
2023Open Access
Supplementary Figure Legend from Small-Molecule IAP Antagonists Sensitize Cancer Cells to TRAIL-Induced Apoptosis: Roles of XIAP and cIAPs
2023Open Access
Supplementary Figure 1 from Small-Molecule IAP Antagonists Sensitize Cancer Cells to TRAIL-Induced Apoptosis: Roles of XIAP and cIAPs
2023Open Access
Supplementary Figure Legend from Small-Molecule IAP Antagonists Sensitize Cancer Cells to TRAIL-Induced Apoptosis: Roles of XIAP and cIAPs
2023Open Access
Data from Small-Molecule IAP Antagonists Sensitize Cancer Cells to TRAIL-Induced Apoptosis: Roles of XIAP and cIAPs
2023Open Access
Data from Small-Molecule IAP Antagonists Sensitize Cancer Cells to TRAIL-Induced Apoptosis: Roles of XIAP and cIAPs
2023Open Access
Primary prophylaxis of neutropenia in extensive stage small cell lung cancer (ESCLC)
Lung Cancer·2020
CCDC 879698: Experimental Crystal Structure Determination
The Cambridge Structural Database·2017Open Access
Characterization of Potent SMAC Mimetics that Sensitize Cancer Cells to TNF Family-Induced Apoptosis
PLoS ONE·2016· 20 citedOpen Access
Ultra-High-Throughput Screening of Natural Product Extracts to Identify Proapoptotic Inhibitors of Bcl-2 Family Proteins
SLAS DISCOVERY·2014· 28 citedOpen Access
Small-Molecule IAP Antagonists Sensitize Cancer Cells to TRAIL-Induced Apoptosis: Roles of XIAP and cIAPs
Molecular Cancer Therapeutics·2013· 51 citedOpen Access
Design, synthesis and evaluation of inhibitor of apoptosis protein (IAP) antagonists that are highly selective for the BIR2 domain of XIAP
Bioorganic & Medicinal Chemistry Letters·2013· 13 citedOpen Access
Expedient Synthesis of Highly Potent Antagonists of Inhibitor of Apoptosis Proteins (IAPs) with Unique Selectivity for ML-IAP
ACS Chemical Biology·2013· 32 cited
TR-FRET-Based High-Throughput Screening Assay for Identification of UBC13 Inhibitors
SLAS DISCOVERY·2011· 38 citedOpen Access
Inhibitor of Apoptosis Proteins
Cambridge University Press eBooks·2011· 3 cited
Design, synthesis and evaluation of monovalent Smac mimetics that bind to the BIR2 domain of the anti-apoptotic protein XIAP
Bioorganic & Medicinal Chemistry Letters·2011· 29 citedOpen Access
Antagonists of IAP-family anti-apoptotic proteins - Probe 2
2011· 1 cited
Table 3, Binding affinity to the XIAP-BIR1/2 and BIR3 domains for representative examples
2011
Figure 2, Key SAR for our second library
2011
Table A1, Bir1/2 vs Bir3 potency and selectivity data for 153 additional compounds
2011
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Frequent Co-authors

John C. Reed(48), Maryla Krajewska(10), Clemencia Pinilla(9), Richard A. Houghten(9), Stanisław Krajewski(7), Guy S. Salvesen(7), Shinichi Kitada(6), Shu‐ichi Matsuzawa(6), Darren Finlay(6), Robert Ardecky(6), Nicholas D. P. Cosford(6), Kristiina Vuori(6), Kathryn R. Ely(5), Santhi Ganji(5), Dayong Zhai(4), Quinn L. Deveraux(4), Adel Nefzi(4), Temesgen Samuel(4), Adam Godzik(4), Juan M. Zapata(4)