Adel Nefzi

Florida International University — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

31h-index4.6kcitations168works1.12yr avg
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Research Topics

Chemical Synthesis and Analysis(109), Click Chemistry and Applications(51), Carbohydrate Chemistry and Synthesis(20), Monoclonal and Polyclonal Antibodies Research(18), Neuropeptides and Animal Physiology(13)

Publications168 total

Design, Synthesis, and Acetylcholinesterase Inhibitory Activity of Novel Oxytocin Analogs as Potential Therapeutics for Alzheimer’s Disease
Preprints.org·2025Open Access
Opioid Affinity of Diazacyclic Peptidomimetic Compounds Derived from Reduced Polyamides
International Journal of Molecular Sciences·2025Open Access
Substituted Triazole-3,5-Diamine Compounds as Novel Human Topoisomerase III Beta Inhibitors
International Journal of Molecular Sciences·2025· 1 citedOpen Access
Targeting Acetylcholinesterase with Oxytocin: A New Avenue in Alzheimer’s Disease Therapeutics
ACS Chemical Neuroscience·2025· 2 cited
Editorial: Inflammaging and immunosenescence: role in aging-associated cardiovascular diseases
Frontiers in Cardiovascular Medicine·2025· 3 citedOpen Access
Interactive effects of morphine and the HIV integrase inhibitor, cabotegravir, in male and female mice
Biomedicine & Pharmacotherapy·2025Open Access
Peripherally Restricted Fused Heterocyclic Peptidomimetic Multifunctional Opioid Agonists as Novel, Potent Analgesics
ACS Medicinal Chemistry Letters·2025· 1 cited
Recent synthetic advances in the preparation of 1,3-thiazole compounds and their therapeutic applications in degenerative diseases
Organic & Biomolecular Chemistry·2025
Synthesis of Diazacyclic and Triazacyclic Small-Molecule Libraries Using Vicinal Chiral Diamines Generated from Modified Short Peptides and Their Application for Drug Discovery
Pharmaceuticals·2024· 3 citedOpen Access
Potential therapeutic use of dermaseptin S4 from the frog <i>Phyllomedusa sauvagii</i> and its derivatives against bacterial pathogens in fish
Journal of Applied Microbiology·2024· 1 cited
Parallel Synthesis of Piperazine Tethered Thiazole Compounds with Antiplasmodial Activity
International Journal of Molecular Sciences·2023· 3 citedOpen Access
Potential Therapeutic Use of Dermaseptin S4 From the Frog &lt;em&gt;Phyllomedusa sauvagii&lt;/em&gt; and Its Derivatives Against Bacterial Pathogens in Fish
Preprints.org·2023· 2 citedOpen Access
Polyheterocyclic peptidomimetics: Parallel solid phase synthesis of oligo cyclic guanidines and their inhibition activity against Mycobacterium tuberculosis DNA gyrase
Bioorganic & Medicinal Chemistry Letters·2023· 3 citedOpen Access
Screening, Deconvolution and Parallel Synthesis of TrisubstitutedPiperazine and Trisubstituted 2,3-diketopierazine Libraries for the RapidIdentification of Antagonists of the Nuclear Retinoic Acid Receptor-relatedOrphan Receptor Gamma (RORγ)
Letters in Drug Design & Discovery·2023· 1 cited
2022 TUNISIAN NATIONAL CONGRESS OF MEDICINE ABSTRACTS.
PubMed·2023
Bis-Cyclic Guanidine Heterocyclic Peptidomimetics as Opioid Ligands with Mixed μ-, κ- and δ-Opioid Receptor Interactions: A Potential Approach to Novel Analgesics
International Journal of Molecular Sciences·2022· 6 citedOpen Access
1,5-Disubstituted Acylated 2-Amino-4,5-dihydroimidazoles as a New Class of Retinoic Acid Receptor–Related Orphan Receptor (ROR) Inhibitors
International Journal of Molecular Sciences·2022· 10 citedOpen Access
Encoding mu-opioid receptor biased agonism with interaction fingerprints
Journal of Computer-Aided Molecular Design·2021· 3 cited
Small Molecule Compounds Identified from Mixture-Based Library Inhibit Binding between Plasmodium falciparum Infected Erythrocytes and Endothelial Receptor ICAM-1
International Journal of Molecular Sciences·2021· 10 citedOpen Access
Evaluating the effect of dermaseptin S4 and its derivatives on multidrug-resistant bacterial strains and on the colon cancer cell line SW620
Environmental Science and Pollution Research·2021· 8 cited
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Frequent Co-authors

Richard A. Houghten(33), John M. Ostresh(19), Marc A. Giulianotti(14), Clemencia Pinilla(7), Colette T. Dooley(5), José L. Medina‐Franco(4), S. A. Arutyunyan(4), Kate Welsh(3), John C. Reed(3), Xicheng Sun(3), Manfred Mutter(3), Jon R. Appel(3), Sureshbabu Dadiboyena(3), Markéta Rinnová(3), Aaron D. Schimmer(2), Zhiliang Wang(2), Torsten Wöhr(2), Franck Olivier Wahl(2), Fabián López-Vallejo(2), Jean‐Philippe Meyer(2)