Colette T. Dooley

Orthopaedic Center of Vero Beach — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

22h-index4.2kcitations78works0.52yr avg
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Research Topics

Chemical Synthesis and Analysis(59), Neuropeptides and Animal Physiology(34), Receptor Mechanisms and Signaling(27), Monoclonal and Polyclonal Antibodies Research(18), Biochemical and Structural Characterization(9)

Publications78 total

Opioid Affinity of Diazacyclic Peptidomimetic Compounds Derived from Reduced Polyamides
International Journal of Molecular Sciences·2025Open Access
Peripherally Restricted Fused Heterocyclic Peptidomimetic Multifunctional Opioid Agonists as Novel, Potent Analgesics
ACS Medicinal Chemistry Letters·2025· 1 cited
Bis-Cyclic Guanidine Heterocyclic Peptidomimetics as Opioid Ligands with Mixed μ-, κ- and δ-Opioid Receptor Interactions: A Potential Approach to Novel Analgesics
International Journal of Molecular Sciences·2022· 6 citedOpen Access
Antinociceptive activity of thiazole-containing cyclized DAMGO and Leu-(Met) enkephalin analogs
Organic & Biomolecular Chemistry·2019· 11 citedOpen Access
Bridging immunogenetics and immunoproteomics: Model positional scanning library analysis for Major Histocompatibility Complex class II DQ in Tursiops truncatus
PLoS ONE·2018· 4 citedOpen Access
CHAPTER 4. Peptide Library Technologies: Mixture-Based Library Generation and Screening
RSC drug discovery/RSC drug discovery series·2017
A one-pot multicomponent approach to a new series of morphine derivatives and their biological evaluation
Organic & Biomolecular Chemistry·2017· 5 cited
Altered secondary structure of Dynorphin A associates with loss of opioid signalling and NMDA-mediated excitotoxicity in SCA23
Human Molecular Genetics·2016· 13 citedOpen Access
Potent μ-Opioid Receptor Agonists from Cyclic Peptides Tyr-<i>c</i>[<scp>d</scp>-Lys-Xxx-Tyr-Gly]: Synthesis, Biological, and Structural Evaluation
Journal of Medicinal Chemistry·2016· 8 citedOpen Access
Direct Phenotypic Screening in Mice: Identification of Individual, Novel Antinociceptive Compounds from a Library of 734 821 Pyrrolidine Bis-piperazines
ACS Combinatorial Science·2015· 8 citedOpen Access
Parallel Synthesis of Hexahydrodiimidazodiazepines Heterocyclic Peptidomimetics and Their in Vitro and in Vivo Activities at μ (MOR), δ (DOR), and κ (KOR) Opioid Receptors
Journal of Medicinal Chemistry·2015· 31 citedOpen Access
Labeling and Expression of Opioid Receptors Using N-terminal Fusion of Fluorescent Proteins
2015Open Access
Fluorescent Delta Selective Opioid Peptides from a Cyclic Peptide Combinatorial Library
2015Open Access
Synthesis and biological evaluations of novel endomorphin analogues containing α-hydroxy-β-phenylalanine (AHPBA) displaying mixed μ/δ opioid receptor agonist and δ opioid receptor antagonist activities
European Journal of Medicinal Chemistry·2014· 16 citedOpen Access
Synthesis and analgesic activity of alkylated, reduced and constrained oligoheterocyclic peptidomimetic analogs of Leu-enkephalin
Bioorganic & Medicinal Chemistry Letters·2014· 6 citedOpen Access
Parallel synthesis of bis-oxazole peptidomimetics
Tetrahedron Letters·2013· 10 cited
Ligand/kappa-opioid receptor interactions: Insights from the X-ray crystal structure
European Journal of Medicinal Chemistry·2013· 13 citedOpen Access
Fluorescent Mu Selective Opioid Ligands from a Mixture Based Cyclic Peptide Library
ACS Combinatorial Science·2012· 12 citedOpen Access
A Novel Method for the Determination of Isokinetic Ratios and Its Application in the Synthesis of Two New Positional Scanning Libraries
ACS Combinatorial Science·2012· 8 cited
Toxicity of 6-hydroxydopamine: live cell imaging of cytoplasmic redox flux
Cell Biology and Toxicology·2012· 17 cited
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Frequent Co-authors

Richard A. Houghten(38), Jon R. Appel(14), Adel Nefzi(14), Clemencia Pinilla(12), Marc A. Giulianotti(12), John M. Ostresh(11), Sylvie E. Blondelle(10), Jay P. McLaughlin(8), Jutta Eichler(7), Shainnel O. Eans(6), Michelle L. Ganno(6), José L. Medina‐Franco(4), Karina Martínez‐Mayorga(4), Radleigh G. Santos(4), Austin B. Yongye(4), R A Houghten(3), Jean M. Bidlack(3), Jaime A. Misler(3), Ginamarie Debevec(3), Laura E. Maida(3)