John M. Ostresh

Torrey Pines Institute For Molecular Studies — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

31h-index4.0kcitations109works0.02yr avg
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Research Topics

Chemical Synthesis and Analysis(91), Monoclonal and Polyclonal Antibodies Research(33), Click Chemistry and Applications(32), Biochemical and Structural Characterization(17), Carbohydrate Chemistry and Synthesis(15)

Publications109 total

Potent antimicrobial small molecules screened as inhibitors of tyrosine recombinases and Holliday junction-resolving enzymes
Molecular Diversity·2011· 29 cited
Small molecule functional analogs of peptides that inhibit λ site-specific recombination and bind Holliday junctions
Bioorganic & Medicinal Chemistry Letters·2010· 22 citedOpen Access
Strategies for the Use of Mixture-Based Synthetic Combinatorial Libraries: Scaffold Ranking, Direct Testing In Vivo, and Enhanced Deconvolution by Computational Methods
Journal of Combinatorial Chemistry·2007· 118 cited
Selection by Site‐Directed Antibodies of Small Regions of Peptides which are Ordered in Water
Novartis Foundation symposium·2007· 2 cited
Identification of potent and highly selective chiral tri-amine and tetra-amine μ opioid receptors ligands: An example of lead optimization using mixture-based libraries
Bioorganic & Medicinal Chemistry Letters·2006· 17 citedOpen Access
Preparation of heterocyclic positional scanning combinatorial libraries from peptides
Kluwer Academic Publishers eBooks·2006
Peptides as precursors in the synthesis of heterocyclic positional scanning combinatorial libraries
Kluwer Academic Publishers eBooks·2005· 1 cited
Combinatorial libraries: Equimolar incorporation of benzaldehyde mixtures in reductive alkylation reactions
Kluwer Academic Publishers eBooks·2005· 2 cited
Solid phase synthesis of heterocyclic combinatorial libraries derived from peptides
Kluwer Academic Publishers eBooks·2005
Solid Phase Synthesis of 3,4,7-Trisubstituted 4,5,8,9-Tetrahydro-3<i>H</i>-imidazo[1,2-<i>a</i>][1,3,5]triazepin-2(7<i>H</i>)-thiones and <i>N</i>-Alkyl-4,5,7,8-tetrahydro-3<i>H</i>-imidazo[1,2-<i>a</i>][1,3,5]triazepin-2-amines
Journal of Combinatorial Chemistry·2005· 11 cited
Inhibitors of XIAP sensitize CD40-activated chronic lymphocytic leukemia cells to CD95-mediated apoptosis
Blood·2005· 57 citedOpen Access
Small-molecule XIAP inhibitors derepress downstream effector caspases and induce apoptosis of acute myeloid leukemia cells
Blood·2005· 125 citedOpen Access
Mixture‐Based Combinatorial Libraries: from Peptides and Peptidomimetics to Small Molecule Acyclic and Heterocyclic Compounds
ChemInform·2004
Inhibition of XIAP Renders Newly CD40-Activated Chronic Lymphocytic Leukemia Cells Sensitive to Fas (CD95) Mediated Apoptosis.
Blood·2004
Solid-phase synthesis of 5-aminotetrazoles
Tetrahedron Letters·2004· 35 cited
Combinatorial Chemistry: Libraries from Libraries, the Art of the Diversity‐Oriented Transformation of Resin‐Bound Peptides and Chiral Polyamides to Low Molecular Weight Acyclic and Heterocyclic Compounds
ChemInform·2004
Combinatorial Chemistry:  Libraries from Libraries, the Art of the Diversity-Oriented Transformation of Resin-Bound Peptides and Chiral Polyamides to Low Molecular Weight Acyclic and Heterocyclic Compounds.
The Journal of Organic Chemistry·2004· 1 cited
Combinatorial Chemistry:  Libraries from Libraries, the Art of the Diversity-Oriented Transformation of Resin-Bound Peptides and Chiral Polyamides to Low Molecular Weight Acyclic and Heterocyclic Compounds
The Journal of Organic Chemistry·2004· 102 cited
Small-molecule antagonists of apoptosis suppressor XIAP exhibit broad antitumor activity
Cancer Cell·2004· 406 cited
Peralkylation: "Libraries from Libraries": Chemical Transformation of Synthetic Combinatorial Libraries
Humana Press eBooks·2003· 6 cited
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Frequent Co-authors

Richard A. Houghten(45), Adel Nefzi(20), Sylvie E. Blondelle(12), Clemencia Pinilla(10), Colette T. Dooley(8), Marc A. Giulianotti(6), Yongping Yu(6), Jon R. Appel(5), Jutta Eichler(5), Achyuta N. Acharya(5), Kate Welsh(3), John C. Reed(3), Barbara Dörner(3), Aaron D. Schimmer(2), Zhiliang Wang(2), Gregory M. Husar(2), Vince T. Hamashin(2), Jean‐Philippe Meyer(2), Yongping Yu(2), Frederick A. Klipstein(2)