Cheuk K. Lau

TransCanada (Canada) — Canada

Medicine · Health Sciences

27h-index1.9kcitations75works0.02yr avg
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Research Topics

Inflammatory mediators and NSAID effects(13), Synthesis and biological activity(11), Synthetic Organic Chemistry Methods(9), Synthesis and Reactions of Organic Compounds(9), Asymmetric Synthesis and Catalysis(8)

Publications75 total

Difluoroethylamines as an amide isostere in inhibitors of cathepsin K
Bioorganic & Medicinal Chemistry Letters·2010· 111 citedOpen Access
Synthesis of 4-alkyl-1, 4-dihydropyridines and related compounds ; Synthesis and thermolysis of β-cyclopropyl-⍺, β-unsaturated ketones and related compounds
Open Collections·2010Open Access
The discovery of MK-0674, an orally bioavailable cathepsin K inhibitor
Bioorganic & Medicinal Chemistry Letters·2009· 24 citedOpen Access
Discovery of [(3-bromo-7-cyano-2-naphthyl)(difluoro)methyl]phosphonic acid, a potent and orally active small molecule PTP1B inhibitor
Bioorganic & Medicinal Chemistry Letters·2008· 55 citedOpen Access
Conformation-assisted Inhibition of Protein-tyrosine Phosphatase-1B Elicits Inhibitor Selectivity over T-cell Protein-tyrosine Phosphatase
Journal of Biological Chemistry·2006· 42 citedOpen Access
Synthesis of AB and CD Spiroketal of Spongistatin 1 (I).
ChemInform·2005· 1 cited
The C3a receptor antagonist SB 290157 has agonist activity
Immunology Letters·2005· 92 cited
Structure Based Design of a Series of Potent and Selective Non‐Peptidic PTP‐1B Inhibitors.
ChemInform·2004· 1 cited
Synthesis of a novel peptidic photoaffinity probe for the PTP-1B enzyme
Bioorganic & Medicinal Chemistry Letters·2004· 13 cited
Structure based design of a series of potent and selective non peptidic PTP-1B inhibitors
Bioorganic & Medicinal Chemistry Letters·2004· 69 citedOpen Access
Synthesis of AB and CD Spiroketal of Spongistatin 1
Synlett·2004· 13 cited
The Structural Basis for the Selectivity of Benzotriazole Inhibitors of PTP1B
Biochemistry·2003· 104 citedOpen Access
THE STRUCTURE OF PHOSPHOTYROSINE PHOSPHATASE 1B IN COMPLEX WITH COMPOUND 2
2003
Progress Towards the Decalin Portion of (+)‐Compactin.
ChemInform·2003
Pyridazinones as selective cyclooxygenase-2 inhibitors
Bioorganic & Medicinal Chemistry Letters·2003· 74 citedOpen Access
Synthesis of<i>syn</i>- and<i>anti</i>-3,5-Dihydroxy-6-heptenoates from 2-Deoxy-<scp>d</scp>-ribose: Intermediates for Polyols Synthesis
Synlett·2003
CCDC 199778: Experimental Crystal Structure Determination
The Cambridge Structural Database·2003Open Access
Progress towards the decalin portion of (+)-compactin
Tetrahedron Asymmetry·2002· 9 cited
ChemInform Abstract: Synthesis and Biological Evaluation of 3‐Heteroaryloxy‐4‐phenyl‐2(5H)‐furanones as Selective Cox‐2 Inhibitors.
ChemInform·2000
ChemInform Abstract: ortho‐Hydroxyalkylation of Aminopyridines: A Novel Approach to Heterocycles.
ChemInform·2000
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Frequent Co-authors

Michel Thérien(13), Claude Dufresne(12), Robert J. Gordon(11), John Scheigetz(10), Jacques Yves Gauthier(9), W. Cameron Black(9), Stacia Kargman(9), Petpiboon Prasit(9), Kathryn Skorey(8), Elizabeth Wong(8), Wanda Cromlish(8), Robert Zamboni(7), S. Charleson(7), Y. LEBLANC(7), Patrick Roy(7), Denis Riendeau(7), Chun Sing Li(6), Robert N. Young(6), Michel Belley(6), J. Y. GAUTHIER(6)