Robert Zamboni

Medicine · Health Sciences

42h-index7.4kcitations164works0.02yr avg
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Research Topics

Asthma and respiratory diseases(22), Chemical Synthesis and Analysis(19), Inflammatory mediators and NSAID effects(15), Fluorine in Organic Chemistry(15), Carbohydrate Chemistry and Synthesis(14)

Publications164 total

PORT-77, a Novel and Potent Inhibitor of ABCG2, Protects Against Skin Photo Toxicity and Liver Damage in a Mouse Model of Erythropoietic Protoporphyria (EPP)
Blood·2024Open Access
Treatment and prevention of pathological mitochondrial dysfunction in retinal degeneration and in photoreceptor injury
Biochemical Pharmacology·2022· 28 citedOpen Access
Pathogenic mitochondrial dysfunction and metabolic abnormalities
Biochemical Pharmacology·2021· 42 citedOpen Access
Klotho Pathways, Myelination Disorders, Neurodegenerative Diseases, and Epigenetic Drugs
BioResearch open access·2020· 32 citedOpen Access
Epigenetic treatment of dermatologic disorders
Drug Development Research·2019· 2 cited
Enthalpy-Driven Stabilization of Transthyretin by AG10 Mimics a Naturally Occurring Genetic Variant That Protects from Transthyretin Amyloidosis
Journal of Medicinal Chemistry·2018· 93 citedOpen Access
Abstract 17426: AG10 Potently and Selectively Stabilizes Transthyretin in vitro and Upon Oral Dosing in Dogs: Potential for Treating Transthyretin Amyloidosis
2017· 1 cited
Abstract 19616: AG10 Stabilizes Pathogenic TTR Variants With High Potency - Potential for an Effective Treatment for TTR Cardiomyopathy
2017· 1 cited
Suppression of CYP1 members of the AHR response by pathogen-associated molecular patterns
Journal of Leukocyte Biology·2017· 10 citedOpen Access
P5846AG10, an orally available, novel transthyretin (TTR) stabilizer: integrated preclinical evaluation predicts a highly effective treatment for TTR amyloid cardiomyopathy
European Heart Journal·2017Open Access
Discovery of ITX 4520: A highly potent orally bioavailable hepatitis C virus entry inhibitor
Bioorganic & Medicinal Chemistry Letters·2012· 24 citedOpen Access
Regulation of nitric oxide synthesis by beta‐adrenergic receptors in the nuclear envelope
The FASEB Journal·2012
Difluoroethylamines as an amide isostere in inhibitors of cathepsin K
Bioorganic & Medicinal Chemistry Letters·2010· 111 citedOpen Access
Potent and highly selective DP1 antagonists with 2,3,4,9-tetrahydro-1H-carbazole as pharmacophore
Bioorganic & Medicinal Chemistry Letters·2010· 29 citedOpen Access
Corrigendum to “Design and synthesis of dipeptidyl nitriles as potent, selective, and reversible inhibitors of cathepsin C” [Bioorg. Med. Chem. Lett. 19 (2009) 5392]
Bioorganic & Medicinal Chemistry Letters·2010· 2 cited
The discovery of MK-0674, an orally bioavailable cathepsin K inhibitor
Bioorganic & Medicinal Chemistry Letters·2009· 24 citedOpen Access
Corrigendum to “Design and synthesis of dipeptidyl nitriles as potent, selective, and reversible inhibitors of cathepsin C” [Bioorg. Med. Chem. Lett. 19 (2009) 5392]
Bioorganic & Medicinal Chemistry Letters·2009
Design and synthesis of dipeptidyl nitriles as potent, selective, and reversible inhibitors of cathepsin C
Bioorganic & Medicinal Chemistry Letters·2009· 42 citedOpen Access
Photo-crosslinking of proteins in intact cells reveals a dimeric structure of cyclooxygenase-2 and an inhibitor-sensitive oligomeric structure of microsomal prostaglandin E2 synthase-1
Archives of Biochemistry and Biophysics·2008· 7 cited
Identification of prostaglandin D2 receptor antagonists based on a tetrahydropyridoindole scaffold
Bioorganic & Medicinal Chemistry Letters·2008· 44 citedOpen Access
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Frequent Co-authors

Donald W. Nicholson(10), Robert N. Young(10), Serge Léger(9), Joshua Rokach(9), M. David Percival(8), Michel Thérien(7), Sophie Roy(6), Sylvie Desmarais(6), Jean‐Pierre Falgueyret(6), Denis Riendeau(6), A. W. Ford‐Hutchinson(6), John P. Vaillancourt(5), Jacques Yves Gauthier(5), Nathalie Chauret(5), Diane Ethier(5), Robert J. Gordon(5), Gillian Greig(5), Joseph A. Mancini(5), Michel Belley(5), Yongxin Han(5)