Joshua Rokach

Florida Institute of Technology — United States

Medicine · Health Sciences

61h-index14.4kcitations369works0.02yr avg
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Research Topics

Asthma and respiratory diseases(67), Eicosanoids and Hypertension Pharmacology(65), Antioxidant Activity and Oxidative Stress(43), Carbohydrate Chemistry and Synthesis(40), Organic Chemistry Cycloaddition Reactions(36)

Publications369 total

Leukotriene receptors in GtoPdb v.2025.3
IUPHAR/BPS Guide to Pharmacology CITE·2025Open Access
Concise Syntheses of Microsomal Metabolites of a Potent OXE (Oxoeicosanoid) Receptor Antagonist
Chemical and Pharmaceutical Bulletin·2023Open Access
Leukotriene receptors in GtoPdb v.2023.1
IUPHAR/BPS Guide to Pharmacology CITE·2023Open Access
Metabolism of anti-inflammatory OXE (oxoeicosanoid) receptor antagonists by nonhuman primates
European Journal of Pharmaceutical Sciences·2022· 2 citedOpen Access
Targeting the OXE receptor with a selective antagonist inhibits allergen‐induced pulmonary inflammation in non‐human primates
British Journal of Pharmacology·2021· 11 citedOpen Access
Leukotriene receptors (version 2020.3) in the IUPHAR/BPS Guide to Pharmacology Database
IUPHAR/BPS Guide to Pharmacology CITE·2020· 1 citedOpen Access
Targeting the OXE receptor as a potential novel therapy for asthma
Biochemical Pharmacology·2020· 22 citedOpen Access
Inhibition of allergen‐induced dermal eosinophilia by an oxoeicosanoid receptor antagonist in non‐human primates
British Journal of Pharmacology·2019· 11 citedOpen Access
Novel highly potent OXE receptor antagonists with prolonged plasma lifetimes that are converted to active metabolites in vivo in monkeys
British Journal of Pharmacology·2019· 12 citedOpen Access
Leukotriene receptors (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database
IUPHAR/BPS Guide to Pharmacology CITE·2019· 2 citedOpen Access
Novel Highly Potent and Metabolically Resistant Oxoeicosanoid (OXE) Receptor Antagonists That Block the Actions of the Granulocyte Chemoattractant 5-Oxo-6,8,11,14-Eicosatetraenoic Acid (5-oxo-ETE)
Journal of Medicinal Chemistry·2018· 8 citedOpen Access
Corrigendum to “In vivo α-hydroxylation of a 2-alkylindole antagonist of the OXE receptor for the eosinophil chemoattractant 5-oxo-6,8,11,14-eicosatetraenoic acid in monkeys” [Biochem. Pharmacol. 138 (2017) 107–118]
Biochemical Pharmacology·2018· 1 cited
Metabolism and pharmacokinetics of a potent N-acylindole antagonist of the OXE receptor for the eosinophil chemoattractant 5-oxo-6,8,11,14-eicosatetraenoic acid (5-oxo-ETE) in rats and monkeys
European Journal of Pharmaceutical Sciences·2018· 7 citedOpen Access
Synthesis of The Leukotrienes and Other Lipoxygenase-Derived Products
2017· 1 cited
Structure-activity relationship study of β-oxidation resistant indole-based 5-oxo-6,8,11,14-eicosatetraenoic acid (5-oxo-ETE) receptor antagonists
Bioorganic & Medicinal Chemistry Letters·2017· 5 citedOpen Access
In vivo α-hydroxylation of a 2-alkylindole antagonist of the OXE receptor for the eosinophil chemoattractant 5-oxo-6,8,11,14-eicosatetraenoic acid in monkeys
Biochemical Pharmacology·2017· 7 citedOpen Access
CCDC 1527527: Experimental Crystal Structure Determination
The Cambridge Structural Database·2017Open Access
Pharmacokinetics and Metabolism of Selective Oxoeicosanoid (OXE) Receptor Antagonists and Their Effects on 5-Oxo-6,8,11,14-eicosatetraenoic Acid (5-Oxo-ETE)-Induced Granulocyte Activation in Monkeys
Journal of Medicinal Chemistry·2016· 14 cited
Design and synthesis of affinity chromatography ligands for the purification of 5-hydroxyeicosanoid dehydrogenase
Bioorganic & Medicinal Chemistry·2016· 6 cited
5-Oxo-ETE and Inflammation
2016· 4 cited
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Frequent Co-authors

Garret A. FitzGerald(21), John A. Lawson(17), Domenico Praticò(12), William S. Powell(6), Robert N. Young(5), Robert Zamboni(5), Mustafa Adiyaman(5), Seongwoo Hwang(5), Yves Girard(5), John Q. Trojanowski(4), Donna D. Baird(3), Muredach P. Reilly(3), Richard Frenette(3), Edward C. Hayes(3), Yvan Guindon(3), Yves Leblanc(3), Brian J. Fitzsimmons(3), Maria B. Kadiiska(2), Beth C. Gladen(2), LeRae Graham(2)