Chih-Min Kam

Georgia Institute of Technology — United States

Medicine · Health Sciences

22h-index1.5kcitations37works0.02yr avg
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Research Topics

Peptidase Inhibition and Analysis(12), Protease and Inhibitor Mechanisms(8), Mast cells and histamine(7), Blood Coagulation and Thrombosis Mechanisms(4), Chemical Synthesis and Analysis(4)

Publications37 total

Design and evaluation of inhibitors for dipeptidyl peptidase I (Cathepsin C)
Archives of Biochemistry and Biophysics·2004· 52 cited
Subsite specificities of granzyme M: a study of inhibitors and newly synthesized thiobenzyl ester substrates
Archives of Biochemistry and Biophysics·2003· 18 cited
Dipeptidyl peptidase I: importance of progranzyme activation sequences, other dipeptide sequences, and the N-terminal amino group of synthetic substrates for enzyme activity
Archives of Biochemistry and Biophysics·2002· 54 cited
Cutaneous protease activity in the mouse ear vesicant model†
Journal of Applied Toxicology·2001· 32 cited
Dipeptide vinyl sulfones suitable for intracellular inhibition of dipeptidyl peptidase I
International Immunopharmacology·2001· 24 cited
Serine and Cysteine Proteases in Sulfur Mustard-Exposed Hairless Mouse Skin: Enzymatic Activity and Inhibition Profiles
Cutaneous and Ocular Toxicology·2000· 7 cited
Granzymes (lymphocyte serine proteases): characterization with natural and synthetic substrates and inhibitors
Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology·2000· 152 cited
Serine and Cysteine Proteases in Sulfur Mustard-Exposed Hairless Mouse Skin: Enzymatic Activity and Inhibition Profiles
Journal of Toxicology Cutaneous and Ocular Toxicology·2000· 5 cited
The Human Cytotoxic T Cell Granule Serine Protease Granzyme H Has Chymotrypsin-like (Chymase) Activity and Is Taken Up into Cytoplasmic Vesicles Reminiscent of Granzyme B-containing Endosomes
Journal of Biological Chemistry·1999· 103 citedOpen Access
Oxyanion-Mediated Inhibition of Serine Proteases<sup>,</sup>
Biochemistry·1998· 32 cited
Synthesis and Evaluation of Diphenyl Phosphonate Esters as Inhibitors of the Trypsin-like Granzymes A and K and Mast Cell Tryptase
Journal of Medicinal Chemistry·1998· 62 cited
Purification and Characterization of Lymphocyte Chymase I, a Granzyme Implicated in Perforin-Mediated Lysis
The Journal of Immunology·1998· 20 cited
Expression and Purification of Enzymatically Active Recombinant Granzyme B in a Baculovirus System
Biochemical and Biophysical Research Communications·1998· 40 cited
Reactions of [<sup>14</sup>C]-3,4-Dichloroisocoumarin with Subunits of Pituitary and Spleen Multicatalytic Proteinase Complexes (Proteasomes)
Biochemistry·1997· 34 cited
Enhanced Serine Protease Activities in the Sulfur Mustard-Exposed Homogenates of Hairless Guinea Pig Skin
International Journal of Toxicology·1997· 13 cited
Recombinant human granzyme A binds to two putative HLA-associated proteins and cleaves one of them
Proceedings of the National Academy of Sciences·1997· 106 citedOpen Access
Characterization, application and potential uses of biotin-tagged inhibitors for lymphocyte serine proteases (granzymes)
Molecular Immunology·1996· 15 cited
Inhibition of Trypsin and Thrombin by Amino(4-amidinophenyl)methanephosphonate Diphenyl Ester Derivatives:  X-ray Structures and Molecular Models<sup>,</sup>
Biochemistry·1996· 54 cited
Mechanism-Based Isocoumarin Inhibitors for Human Leukocyte Elastase. Effect of the 7-Amino Substituent and 3-Alkoxy Group in 3-Alkoxy-7-amino-4-chloroisocoumarins on Inhibitory Potency
Journal of Medicinal Chemistry·1995· 39 cited
[1] Peptide thioester substrates for serine peptidases and metalloendopeptidases
Methods in enzymology on CD-ROM/Methods in enzymology·1995· 26 cited
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Frequent Co-authors

James C. Powers(30), Dorothy Hudig(11), John E. Kerrigan(4), Ulrike Winkler(4), James C. Powers(4), Nigel Allison(4), Józef Oleksyszyn(3), Joe Selzler(3), Koert M. Dolman(3), Roel Goldschmeding(3), A. E. G. Kr. von dem Borne(3), Judy Lieberman(2), Bogdan Boduszek(2), Delwin S. Jackson(2), Stephanie A. Fraser(2), J. A. Bertrand(2), Steven R. Presnell(2), R. Richard Plaskon(2), F. L. Suddath(2), Loren Dean Williams(2)