Richard J. Kascsak

New York State Office for People With Developmental Disabilities — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

31h-index3.6kcitations74works0.02yr avg
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Research Topics

Prion Diseases and Protein Misfolding(55), Trace Elements in Health(22), Alzheimer's disease research and treatments(14), RNA regulation and disease(9), Neurological diseases and metabolism(7)

Publications74 total

Development of a Quantitative FMRP Assay for Mouse Tissue Applications
Genes·2021· 5 citedOpen Access
P3‐187: ANTI‐PRION PROTEIN ANTIBODY 6D11 DISRUPTS RECYCLING PROPAGATION OF THE PRP<sup>SC</sup> CONFORMER AND RESTORES CELLULAR PROTEOSTASIS OF PRION PROTEIN
Alzheimer s & Dementia·2019Open Access
The role of reduced expression of fragile X mental retardation protein in neurons and increased expression in astrocytes in idiopathic and syndromic autism (duplications 15q11.2‐q13)
Autism Research·2018· 7 cited
Anti-prion Protein Antibody 6D11 Restores Cellular Proteostasis of Prion Protein Through Disrupting Recycling Propagation of PrPSc and Targeting PrPSc for Lysosomal Degradation
Molecular Neurobiology·2018· 15 cited
[P1–234]: ANTI‐PRP MAB 6D11 DISRUPTS CELLULAR TRAFFICKING OF PRP<sup>C</sup> AND PRP<sup>SC</sup> AND TARGETS PRP<sup>SC</sup> FOR LYSOSOMAL DEGRADATION
Alzheimer s & Dementia·2017Open Access
Detection and Quantification of the Fragile X Mental Retardation Protein 1 (FMRP)
Genes·2016· 22 citedOpen Access
Fragile X protein in newborn dried blood spots
BMC Medical Genetics·2014· 19 citedOpen Access
Altered Lymphocyte Proliferation and Innate Immune Function in Scrapie 139A- and ME7-Infected Mice
Viral Immunology·2013· 3 citedOpen Access
Fragile X Screening by Quantification of FMRP in Dried Blood Spots by a Luminex Immunoassay
Journal of Molecular Diagnostics·2013· 55 cited
Inflammatory mediators are inhibited by a taurine metabolite in CpG oligodeoxynucleotide and IFN-r activated macrophage cell line.
PubMed·2013· 7 cited
P3‐468: Induction of TLR9 signaling in 3xTg‐AD mice
Alzheimer s & Dementia·2011
Anti-PrPC monoclonal antibody infusion as a novel treatment for cognitive deficits in an alzheimer's disease model mouse
BMC Neuroscience·2010· 168 citedOpen Access
Immunomodulation Targeting Abnormal Protein Conformation Reduces Pathology in a Mouse Model of Alzheimer's Disease
PLoS ONE·2010· 48 citedOpen Access
P3‐461: Anti‐PrP<sup>C</sup> monoclonal antibody infusion as a novel treatment for Aß oligomer cognitive deficits
Alzheimer s & Dementia·2010· 4 cited
P3‐371: Stimulation of innate immunity via Toll‐like receptor 9 mitigates Alzheimer pathology
Alzheimer s & Dementia·2010
P3‐463: Development of conformational monoclonal antibodies that detects multiple amyloid proteins
Alzheimer s & Dementia·2010
Reiterating the Epitope Specificity of Prion-specific mAb 3F4
Journal of Biological Chemistry·2010· 11 citedOpen Access
Species-Dependent Differences in Cofactor Utilization for Formation of the Protease-Resistant Prion Protein in Vitro
Biochemistry·2010· 91 citedOpen Access
O3‐06‐02: Toll‐like receptor 9 ligand CpG ODN as a new highly effective agent for prevention and/or treatment of Alzheimer's disease
Alzheimer s & Dementia·2009· 1 cited
O2‐05‐03: Immunotherapy targeting abnormal protein conformation
Alzheimer s & Dementia·2009· 20 cited
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Frequent Co-authors

Richard I. Carp(18), Thomas Wısnıewskı(15), Regina Kascsak(12), Richard Rubenstein(11), Harry C. Meeker(9), Daryl S. Spinner(7), Giuseppe LaFauci(7), Regina B. Kascsak(6), Xuemin Ye(6), Frances Prelli(5), Blas Frangione(5), W. Ted Brown(5), Pankaj Mehta(5), Henrieta Scholtzova(5), Henryk M. Wı́sniewski(5), Gabriela P. Saborı́o(4), Pièrre Aucouturier(4), Tatyana Adayev(4), Nathan R. Deleault(3), James C. Geoghegan(3)