James R. Trudell

Biochemistry, Genetics and Molecular Biology · Life Sciences

51h-index9.3kcitations255works0.02yr avg
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Research Topics

Nicotinic Acetylcholine Receptors Study(76), Receptor Mechanisms and Signaling(70), Neuroscience and Neuropharmacology Research(66), Ion channel regulation and function(46), Lipid Membrane Structure and Behavior(38)

Publications255 total

Effects of COX-1 Enzyme Inhibitions by NSAIDs
2025Open Access
Modulation of α1β3γ2 GABA <sub>A</sub> receptors expressed in <i>X. laevis</i> oocytes using a propofol photoswitch tethered to the transmembrane helix
Proceedings of the National Academy of Sciences·2021· 8 citedOpen Access
Residues in Transmembrane Segments of the P2X4 Receptor Contribute to Channel Function and Ethanol Sensitivity
International Journal of Molecular Sciences·2020· 9 citedOpen Access
Residues in Transmembrane Segments of the P2X4 Receptor Contribute to Channel Function and Ethanol Sensitivity
Preprints.org·2020· 5 citedOpen Access
An intersubunit electrostatic interaction in the GABAA receptor facilitates its responses to benzodiazepines
Journal of Biological Chemistry·2018· 13 citedOpen Access
Inter- and Intra-Subunit Butanol/Isoflurane Sites of Action in the Human Glycine Receptor
Frontiers in Molecular Neuroscience·2016· 7 citedOpen Access
Principal Components from Ligand-Gated Ion Channel Structures Enable Ensemble Studies of Microsecond-Scale Transitions
Biophysical Journal·2016Open Access
Identification of an Inhibitory Alcohol Binding Site in GABAaRho1
Biophysical Journal·2016Open Access
Identification of an Inhibitory Alcohol Binding Site in GABA<sub>A</sub>ρ1 Receptors
ACS Chemical Neuroscience·2015· 13 cited
P-54PHYSICOCHEMICAL DETERMINANTS OF ALCOHOL BINDING IN A MODEL LIGAND-GATED ION CHANNEL
Alcohol and Alcoholism·2015· 1 citedOpen Access
Ethanol Modulation is Quantitatively Determined by the Transmembrane Domain of Human<i>α</i>1 Glycine Receptors
Alcoholism Clinical and Experimental Research·2015· 5 citedOpen Access
Manipulations of extracellular Loop 2 in α1 GlyR ultra-sensitive ethanol receptors (USERs) enhance receptor sensitivity to isoflurane, ethanol, and lidocaine, but not propofol
Neuroscience·2015· 7 citedOpen Access
Molecular Modeling of a Tandem Two Pore Domain Potassium Channel Reveals a Putative Binding Site for General Anesthetics
ACS Chemical Neuroscience·2014· 21 citedOpen Access
Glycine and GABAA Ultra-Sensitive Ethanol Receptors as Novel Tools for Alcohol and Brain Research
Molecular Pharmacology·2014· 15 citedOpen Access
P2X4 receptors (P2X4Rs) represent a novel target for the development of drugs to prevent and/or treat alcohol use disorders
Frontiers in Neuroscience·2014· 57 citedOpen Access
Alcohol dependence: molecular and behavioral evidence
Trends in Pharmacological Sciences·2014· 99 citedOpen Access
Synthesis and functional survey of new Tacrine analogs modified with nitroxides or their precursors
European Journal of Medicinal Chemistry·2014· 13 citedOpen Access
Seeking Structural Specificity: Direct Modulation of Pentameric Ligand-Gated Ion Channels by Alcohols and General Anesthetics
Pharmacological Reviews·2014· 55 citedOpen Access
Avermectins differentially affect ethanol intake and receptor function: implications for developing new therapeutics for alcohol use disorders
The International Journal of Neuropsychopharmacology·2014· 27 citedOpen Access
Contribution of Structural Elements to Activation and Allosteric Modulation in an Anionic Ligand-Gated Ion Channel
Biophysical Journal·2014Open Access
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Frequent Co-authors

R. Adron Harris(15), Neil L. Harrison(8), Ellis N. Cohen(8), Edward Bertaccini(6), Edmond I. Eger(6), Daryl L. Davies(6), Joan J. Kendig(5), Donald D. Koblin(5), John H. Dawson(4), Ronald L. Alkana(4), Thomas L. Kash(3), Andrew Jenkins(3), Maria Paola Mascia(3), S. John Mihic(3), E. Bunnenberg(3), Carl Djerassi(3), Andrew Pohorille(3), Michael J. Halsey(3), Rebecca J. Howard(3), Erik Lindahl(3)