Lori C. Gowen

Regeneron (United States) — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

13h-index2.8kcitations16works0.02yr avg
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Research Topics

BRCA gene mutations in cancer(5), DNA Repair Mechanisms(3), Genetic factors in colorectal cancer(3), Genomics and Chromatin Dynamics(2), CRISPR and Genetic Engineering(2)

Publications16 total

The mutation<i>ROR2W749X</i>, linked to human BDB, is a recessive mutation in the mouse, causing brachydactyly, mediating patterning of joints and modeling recessive Robinow syndrome
Development·2008· 28 cited
Mice genetically deficient in neuromedin U receptor 2, but not neuromedin U receptor 1, have impaired nociceptive responses
Pain·2007· 46 cited
Decreased Hepatic Futile Cycling Compensates for Increased Glucose Disposal in the <i>Pten</i> Heterodeficient Mouse
Diabetes·2006· 24 citedOpen Access
VEGF-dependent plasticity of fenestrated capillaries in the normal adult microvasculature
American Journal of Physiology-Heart and Circulatory Physiology·2005· 766 cited
Erratum: Absence of the lipid phosphatase SHIP2 confers resistance to dietary obesity
Nature Medicine·2005· 1 citedOpen Access
Resistance to diet-induced obesity in mice globally overexpressing OGH/GPB5
Proceedings of the National Academy of Sciences·2005· 38 citedOpen Access
Absence of the lipid phosphatase SHIP2 confers resistance to dietary obesity
Nature Medicine·2005· 248 cited
Retraction
Science·2003· 13 cited
Targeted Disruption of the Osteoblast/Osteocyte Factor 45 Gene (OF45) Results in Increased Bone Formation and Bone Mass
Journal of Biological Chemistry·2003· 296 citedOpen Access
Mice heterozygous for a Brca1 or Brca2 mutation display distinct mammary gland and ovarian phenotypes in response to diethylstilbestrol.
PubMed·2000· 45 cited
BRCA1 deficient embryonic stem cells display a decreased homologous recombination frequency and an increased frequency of non-homologous recombination that is corrected by expression of a Brca1 transgene
Oncogene·1999· 195 cited
Mammary tumor formation in p53- and BRCA1-deficient mice.
PubMed·1999· 84 cited
BRCA1 Required for Transcription-Coupled Repair of Oxidative DNA Damage
Science·1998· 498 cited
Microsatellite mutation rates in cancer cell lines deficient or proficient in mismatch repair
Oncogene·1998· 44 cited
Characterization of Brca1 Deficient Mice
Breast Disease·1998· 7 cited
Brca1 deficiency results in early embryonic lethality characterized by neuroepithelial abnormalities
Nature Genetics·1996· 481 cited

Frequent Co-authors

Beverly H. Koller(7), Mark W. Sleeman(6), George D. Yancopoulos(5), Anne M. Latour(4), Stanley J. Wiegand(4), Karen E. Anderson(3), Katherine E. Wortley(3), David M. Valenzuela(3), Anna V. Avrutskaya(2), Steven A. Leadon(2), Jennifer Kintner(2), William O. Kline(2), Trevor N. Stitt(2), David J. Glass(2), John N. Snouwaert(2), Andrew Murphy(2), Aris N. Economides(2), Tomomi Kamba(1), Betty Y. Tam(1), Hiroya Hashizume(1)