Peter Colosi

BioMarin (United States) — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

32h-index4.4kcitations60works0.02yr avg
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Research Topics

Virus-based gene therapy research(29), Retinal Development and Disorders(18), Retinal Diseases and Treatments(11), Growth Hormone and Insulin-like Growth Factors(10), RNA Interference and Gene Delivery(9)

Publications60 total

Application of in-vitro-cultured primary hepatocytes to evaluate species translatability and AAV transduction mechanisms of action
Molecular Therapy — Methods & Clinical Development·2022· 13 citedOpen Access
A CEP290 C-Terminal Domain Complements the Mutant CEP290 of Rd16 Mice In Trans and Rescues Retinal Degeneration
Cell Reports·2018· 40 citedOpen Access
Retinal AAV8-RS1 Gene Therapy for X-Linked Retinoschisis: Initial Findings from a Phase I/IIa Trial by Intravitreal Delivery
Molecular Therapy·2018· 256 citedOpen Access
Gene Therapy with BMN 270 Results in Therapeutic Levels of FVIII in Mice and Primates and Normalization of Bleeding in Hemophilic Mice
Molecular Therapy·2017· 73 citedOpen Access
Soluble FLT1 Gene Therapy Alleviates Brain Arteriovenous Malformation Severity
Stroke·2017· 27 citedOpen Access
Preclinical Dose-Escalation Study of Intravitreal AAV-RS1 Gene Therapy in a Mouse Model of X-linked Retinoschisis: Dose-Dependent Expression and Improved Retinal Structure and Function
Human Gene Therapy·2016· 89 citedOpen Access
Ocular and systemic safety of a recombinant AAV8 vector for X-linked retinoschisis gene therapy: GLP studies in rabbits and Rs1-KO mice
Molecular Therapy — Methods & Clinical Development·2016· 34 citedOpen Access
Isolation, purification, and charact( placental lactogen (placental hormone/biochemical properties/mammary gland receptoi
2016
Human Factor VIII Expression and Normalization of Bleeding Following AAV Gene Therapy in a Double Knockout Mouse Model of Hemophilia
Blood·2015
Diabetes enhances the efficacy of AAV2 vectors in the retina: therapeutic effect of AAV2 encoding vasoinhibin and soluble VEGF receptor 1
Laboratory Investigation·2015· 28 citedOpen Access
Long-term rescue of cone photoreceptor degeneration in retinitis pigmentosa 2 (<i>RP2</i>)-knockout mice by gene replacement therapy
Human Molecular Genetics·2015· 43 citedOpen Access
Gene therapy rescues cone function and viability in Rp2 knockout mice over a broad vector dose range and a wide therapeutic time window
Investigative Ophthalmology & Visual Science·2015
714. Gene Therapy Rescues Cone Function and Viability in an Rp2 Knockout Mouse Model for X-Linked Retinitis Pigmentosa Over a Wide Dose Range and a Broad Therapeutic Time Window
Molecular Therapy·2015Open Access
385. Intravenous Delivery of AAV9-CMV-sFLT1 Reduces the Severity of Brain Arteriovenous Malformation Without Causing Significant Side Effects in a Mouse Model
Molecular Therapy·2015Open Access
A long-term efficacy study of gene replacement therapy for RPGR-associated retinal degeneration
Human Molecular Genetics·2015· 71 citedOpen Access
Preclinical Safety Evaluation of a Recombinant AAV8 Vector for X-Linked Retinoschisis After Intravitreal Administration in Rabbits
Human Gene Therapy Clinical Development·2014· 29 citedOpen Access
Diabetes enhances the efficacy of adeno-associated virus vectors in rat retina
Investigative Ophthalmology & Visual Science·2014
A Low Dose AAV Vector Administration Preserves Cone Function in an Rp2 Knockout Mouse Model for Retinitis Pigmentosa
Investigative Ophthalmology & Visual Science·2014
Preclinical Development of AAV Vectors for the Treatment of X-linked Retinitis Pigmentosa Caused by RPGR Mutations
Investigative Ophthalmology & Visual Science·2014
Laser Photocoagulation Enhances Adeno-Associated Viral Vector Transduction of Mouse Retina
Human Gene Therapy Methods·2013· 31 citedOpen Access
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Frequent Co-authors

Zhijian Wu(16), Frank Talamantes(11), Suja Hiriyanna(9), Gary J. Kurtzman(7), Paul A. Sieving(5), Katherine A. High(5), Tiansen Li(5), Anand Swaroop(5), Yong Zeng(4), Camasamudram Vijayasarathy(4), Ronald A. Bush(4), Shangzhen Zhou(4), Hiroyuki Nakai(4), Michael A. Lochrie(4), Glenn F. Pierce(4), Suddhasil Mookherjee(4), Dario Marangoni(3), Lisa L. Wei(3), Peter H. Smith(3), L. Ogren(3)