Jean-Christophe Hoflack

Roche (Switzerland) — Switzerland

Medicine · Health Sciences

13h-index1.1kcitations24works17.32yr avg
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Research Topics

Hepatitis B Virus Studies(4), Pharmacogenetics and Drug Metabolism(4), Hepatitis C virus research(3), Gene expression and cancer classification(3), PARP inhibition in cancer therapy(3)

Publications24 total

SAT-314 HBV RNA ultra-deep sequencing as a tool for HBV genotyping and resistance monitoring in virologically-suppressed individuals with chronic hepatitis B infection
Journal of Hepatology·2025
THU-270 HBV genotype association with response to xalnesiran in nucleos (t)ide analogue treated participants with chronic hepatitis B infection in the Piranga phase 2 platform study
Journal of Hepatology·2025
Assessing Hybridization-Dependent Off-Target Risk for Therapeutic Oligonucleotides: Updated Industry Recommendations
Nucleic Acid Therapeutics·2025· 13 citedOpen Access
A liver immune rheostat regulates CD8 T cell immunity in chronic HBV infection
Nature·2024· 56 citedOpen Access
Combining In Vivo and Organotypic In Vitro Approaches to Assess the Human Relevance of Basimglurant (RG7090), a Potential CAR Activator
Toxicological Sciences·2020· 4 citedOpen Access
Drug-induced Obstructive and Retrograde Nephropathy Associated with α2u-globulin in Male Rats
Toxicologic Pathology·2018· 3 citedOpen Access
Tailoring in silico model to electrophysiology of individual iPSC-derived cardiomyocyte lines: One-size fits all?
Journal of Pharmacological and Toxicological Methods·2018
Cardiac spheroid co-cultures as a novel in vitro model to study human heart microenvironment
Journal of Pharmacological and Toxicological Methods·2018
Use of toxicogenomics in drug safety evaluation: Current status and an industry perspective
Regulatory Toxicology and Pharmacology·2018· 32 cited
HtrA1 Mediated Intracellular Effects on Tubulin Using a Polarized RPE Disease Model
EBioMedicine·2017· 20 citedOpen Access
A novel orally available small molecule that inhibits hepatitis B virus expression
Journal of Hepatology·2017· 137 cited
Cardiac spheroids as promising in vitro models to study the human heart microenvironment
Scientific Reports·2017· 215 citedOpen Access
How much of a cardiomyocyte can we get from stem cells? Setting up metrics for cardiac cell models
Journal of Pharmacological and Toxicological Methods·2016
Carnitine Palmitoyltransferase 2 (CPT2) Inhibition in Rats And Dogs Resembles Inborn Human CPT2 Deficiency
The FASEB Journal·2015
Disease Modeling and Phenotypic Drug Screening for Diabetic Cardiomyopathy using Human Induced Pluripotent Stem Cells
Cell Reports·2014· 239 citedOpen Access
Characterization of post-surgical alterations in the bile duct-cannulated rat
Xenobiotica·2011· 8 cited
Primary Endothelial Damage Is the Mechanism of Cardiotoxicity of Tubulin-Binding Drugs
Toxicological Sciences·2010· 62 citedOpen Access
Mechanisms underlying off-target effects of the cholesteryl ester transfer protein inhibitor torcetrapib involve L-type calcium channels
Journal of Hypertension·2010· 64 cited
Characterization and Interlaboratory Comparison of a Gene Expression Signature for Differentiating Genotoxic Mechanisms
Toxicological Sciences·2009· 73 citedOpen Access
Comparison of Coumarin-Induced Toxicity between Sandwich-Cultured Primary Rat Hepatocytes and Rats in Vivo: A Toxicogenomics Approach
Drug Metabolism and Disposition·2006· 35 cited
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Frequent Co-authors

Laura Badi(6), Nicholas Flint(5), Liudmila Polonchuk(4), Mamta Chabria(4), Guy G. Poirier(4), Thomas P. Singer(3), Frédéric Delobel(2), Tony Kam‐Thong(2), Mark Burcin(2), Roberto Iacone(2), Gemma A. Figtree(2), Michael J. Davies(2), Carmine Gentile(2), Souphalone Luangsay(2), Jitao David Zhang(2), Roland Schmucki(2), Juliane Siebourg‐Polster(2), Serge Desnoyers(2), Girish M. Shah(2), James B. Kirkland(2)