Günter Legler

University of Cologne — Germany

Chemistry · Physical Sciences

36h-index3.9kcitations91works0.02yr avg
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Research Topics

Carbohydrate Chemistry and Synthesis(54), Enzyme Production and Characterization(28), Glycosylation and Glycoproteins Research(23), Enzyme Catalysis and Immobilization(21), Lysosomal Storage Disorders Research(16)

Publications91 total

Glycosidase Inhibition by Basic Sugar Analogs and the Transition State of Enzymatic Glycoside Hydrolysis
1998· 16 cited
Iminoalditols as Affinity Ligands for the Purification of Glycosidases
1998· 2 cited
Two isosteric fluorinated derivatives of the powerful glucosidase inhibitors, 1-deoxynojirimycin and 2,5-dideoxy-2,5-imino-d-mannitol: Syntheses and glucosidase-inhibitory activities of 1,2,5-trideoxy-2-fluoro-1,5-imino-d-glucitol and of 1,2,5-trideoxy-1-fluoro-2,5-imino-d-mannitol
Carbohydrate Research·1997· 61 cited
Purification and Characterization of a Microsomal Bile Acid β-Glucosidase from Human Liver
Journal of Biological Chemistry·1997· 43 citedOpen Access
N1-Alkyl-d-gluconamidines: Are they ‘perfect’ mimics of the first transition state of glucosidase action?
Carbohydrate Research·1996· 22 cited
Synthesis, from nojirimycin, of N1-alkyl-d-gluconamidines as potential glucosidase inhibitors
Carbohydrate Research·1996· 21 cited
A novel approach to the 1-deoxynojirimycin system: Synthesis from sucrose of 2-acetamido-1,2-dideoxynojirimycin, as well as some 2-N-modified derivatives
Carbohydrate Research·1996· 25 cited
Synthesis of 1,5-dideoxy-1,5-imino-d-arabinitol (5-nor-l-fuco-1-deoxynojirimycin) and its application for the affinity purification and characterisation of α-l-fucosidase
Carbohydrate Research·1995· 45 cited
Preliminary Communications First liquid crystalline derivatives of umbelliferyl β-D-glucoside [1]
Liquid Crystals·1995· 13 cited
A new family of carbohydrate liquid crystals.<i>N</i>-Alkylated 1-deoxynojirimycin derivatives [1]
Liquid Crystals·1994· 11 cited
2,5-dideoxy-2,5-imino-d-mannitol and -d-glucitol. Two-step bio-organic syntheses from 5-azido-5-deoxy-d-glucofuranose and -l-idofuranose; evaluation as glucosidase inhibitors and application in affinity purification and characterisation of invertase from yeast
Carbohydrate Research·1993· 40 cited
Mechanism of enzymic glycoside hydrolysis and of glycosyl transfer by glycosidases and glycosyltransferases
Carbohydrate Research·1993· 12 cited
(±)-6-Acetamido-1,2-anhydro-6-deoxy-myo-inositol: a tight-binding inhibitor and pseudosubstrate for N-acetyl-β-glucosaminidases
Carbohydrate Research·1992· 16 cited
Bovine N-acetyl-β-d-glucosaminidase: affinity purification and characterization of its active site with nitrogen containing analogs of N-acetylglucosamine
Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology·1991· 29 cited
Glycoside Hydrolases: Mechanistic Information from Studies with Reversible and Irreversible Inhibitors
Advances in carbohydrate chemistry and biochemistry·1990· 550 cited
Synthesis and Inhibitory Properties of 2-Acetamido-2-Deoxynojirimycin (2-Acetamido-5-amino-2,5-dideoxy-<u><u>D</u></u>-glucopyranose,<u>1</u>) and 2-Acetamido-1,2-dideoxynojirimycin (2-Acetamido-1,5-imino-1,2,5-trideoxy-<u><u>D</u></u>-Glucitol, 2)
Journal of Carbohydrate Chemistry·1989· 48 cited
Isolation of a cytosolic β-glucosidase from calf liver and characterization of its active site with alkyl glucosides and basic glycosyl derivatives
Archives of Biochemistry and Biophysics·1988· 39 cited
Splenic Glucocerebrosidase and Its Cytosolic Activator Protein: Effects on Substrate Hydrolysis and Covalent Inhibition by Conduritol B Epoxides
1988· 1 cited
Active site directed inhibition of a cytosolic β-glucosidase from calf liver by bromoconduritol B epoxide and bromoconduritol F
Archives of Biochemistry and Biophysics·1988· 35 cited
β-Glucocerebrosidase: Mechanistic Studies With Covalent and Non-Covalent Inhibitors
1988
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Frequent Co-authors

Ernst Bause(9), Arnold Stütz(4), Harald Hettkamp(3), Monika Herrchen(3), Günther Gradnig(3), Elisabeth Jülich(2), Jürgen Schweden(2), Christian W. Ekhart(2), Stephen G. Withers(2), K. ROESER(2), Karen M. Osiecki-Newman(2), Diane Fabbro(2), Robert J. Desnick(2), Gregory A. Grabowski(2), Elisabeth Kappes(2), Rudolf Tschesche(2), Erhard Bieberich(2), Kurt Heyns(2), Marie-Therese Finken(2), Ulrike Fuhrmann(1)