Futoshi Shiga

Scripps Research Institute — United States

Chemistry · Physical Sciences

9h-index398citations19works0.02yr avg
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Research Topics

Synthesis and Biological Evaluation(6), Catalytic C–H Functionalization Methods(4), Synthetic Organic Chemistry Methods(4), Bioactive Compounds and Antitumor Agents(4), Microbial Natural Products and Biosynthesis(3)

Publications19 total

Asymmetric Total Synthesis of (+)‐ and ent‐(‐)‐Yatakemycin (I) and Duocarmycin SA (II): Evaluation of Yatakemycin Key Partial Structures and Its Unnatural Enantiomer.
ChemInform·2007
Asymmetric Total Synthesis of (+)- and <i>ent</i>-(−)-Yatakemycin and Duocarmycin SA:  Evaluation of Yatakemycin Key Partial Structures and Its Unnatural Enantiomer
Journal of the American Chemical Society·2006· 75 citedOpen Access
Design and synthesis of novel 7-heterocycle-6-trifluoromethyl-3-oxoquinoxaline-2-carboxylic acids bearing a substituted phenyl group as superior AMPA receptor antagonists with good physicochemical properties
Bioorganic & Medicinal Chemistry·2005· 13 cited
Design, synthesis, and AMPA receptor antagonistic activity of a novel 6-nitro-3-oxoquinoxaline-2-carboxylic acid with a substituted phenyl group at the 7 position
Bioorganic & Medicinal Chemistry·2005· 20 cited
Synthesis and AMPA Receptor Antagonistic Activity of a Novel 7‐Imidazolyl‐6‐trifluoromethyl Quinoxalinecarboxylic Acid with a Substituted Phenyl Group and Improved Its Good Physicochemical Properties by Introduced CF<sub>3</sub> Group.
ChemInform·2005
Synthesis and AMPA receptor antagonistic activity of a novel 7-imidazolyl-6-trifluoromethyl quinoxalinecarboxylic acid with a substituted phenyl group and improved its good physicochemical properties by introduced CF3 group
Bioorganic & Medicinal Chemistry Letters·2004· 6 cited
Synthesis and AMPA Receptor Antagonistic Activity of a Novel Class of Quinoxalinecarboxylic Acid with a Substituted Phenyl Group at the C‐7 Position.
ChemInform·2004
Synthesis and AMPA receptor antagonistic activity of a novel class of quinoxalinecarboxylic acid with a substituted phenyl group at the C-7 position
Bioorganic & Medicinal Chemistry Letters·2003· 21 cited
ChemInform Abstract: Novel Syntheses of Optically Active CC‐1065, U‐73,975(Adozelesin), U‐80,244(Carzelesin), U‐77,779(Bizelesin), KW‐2189, and DU‐86.
ChemInform·1998
ChemInform Abstract: Synthesis and Antitumor Activity of Novel Cyclopropapyrroloindole (CPI) Derivatives Bearing Methoxycarbonyl and Trifluoromethyl Groups.
ChemInform·1997
Synthesis and antitumor activity of novel cyclopropapyrroloindole(CPI) derivatives bearing methoxycarbonyl and trifluoromethyl groups
Bioorganic & Medicinal Chemistry Letters·1997· 32 cited
Novel Syntheses of Optically Active CC-1065, U-73,975(Adozelesin), U-80,244(Carzelesin), U-77,779 (Bizelesin), KW-2189, and DU-86
Heterocycles·1997· 10 citedOpen Access
ChemInform Abstract: Condensed Heteroaromatic Ring Systems. Part 24. Palladium‐Catalyzed Cyclization of 2‐Substituted Phenylacetylenes in the Presence of Carbon Monoxide.
ChemInform·1995
Condensed heteroaromatic ring systems. XXIV. Palladium-catalyzed cyclization of 2-substituted phenylacetylenes in the presence of carbon monoxide
Tetrahedron·1994· 136 cited
ChemInform Abstract: Preparation of Ethyl Arylpropiolates from Aryl Iodides by Palladium‐ Catalyzed Cross‐Coupling Reaction.
ChemInform·1992
ChemInform Abstract: Synthesis and Reaction of Tributylstannylpyrazoles.
ChemInform·1992
Synthesis of 6-Alkylaminopyridazine-3-carboxylic Acid Derivatives as Dopamine &amp;beta;-Hydroxylase Inhibitors
YAKUGAKU ZASSHI·1992· 1 citedOpen Access
Preparation of Ethyl Arylpropiolates from Aryl Iodides by Palladium-Catalyzed Cross-Coupling Reaction
Synthesis·1992· 60 cited
Synthesis and Reaction of Tributylstannylpyrazoles
Heterocycles·1992· 24 citedOpen Access

Frequent Co-authors

Hiroshi Yamanaka(7), Yasuo Takano(6), Jun Asano(6), Yoshinori Kondo(5), Tsuyosi Anraku(5), Daishi Uchiyama(4), Yasumichi Fukuda(4), Hirosuke Furuta(4), Takao Sakamoto(3), Naoki Ando(3), Hideharu Uchiki(3), Wataru Hori(3), Takashi Uno(3), T. SAKAMOTO(3), Naoko Murata(2), Mark S. Tichenor(2), John D. Trzupek(2), David B. Kastrinsky(2), Inkyu Hwang(2), Dale L. Boger(2)