Caroline E. Lilley

Amgen (United States) — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

22h-index3.7kcitations26works0.02yr avg
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Research Topics

Virus-based gene therapy research(10), DNA Repair Mechanisms(8), Herpesvirus Infections and Treatments(8), CRISPR and Genetic Engineering(5), Cytomegalovirus and herpesvirus research(5)

Publications26 total

Critical analysis of an oncolytic herpesvirus encoding granulocyte-macrophage colony stimulating factor for the treatment of malignant melanoma
Oncolytic Virotherapy·2014· 23 citedOpen Access
Viral E3 Ubiquitin Ligase-Mediated Degradation of a Cellular E3: Viral Mimicry of a Cellular Phosphorylation Mark Targets the RNF8 FHA Domain
Molecular Cell·2012· 81 citedOpen Access
The Intrinsic Antiviral Defense to Incoming HSV-1 Genomes Includes Specific DNA Repair Proteins and Is Counteracted by the Viral Protein ICP0
PLoS Pathogens·2011· 125 citedOpen Access
Changing the ubiquitin landscape during viral manipulation of the DNA damage response
FEBS Letters·2011· 20 citedOpen Access
Keeping Viruses in Chk: DNA Damage Signaling Puts the Brakes on Transformation
Cell Host & Microbe·2010· 5 citedOpen Access
Genomes in Conflict: Maintaining Genome Integrity During Virus Infection
Annual Review of Microbiology·2010· 181 cited
A viral E3 ligase targets RNF8 and RNF168 to control histone ubiquitination and DNA damage responses
The EMBO Journal·2010· 174 citedOpen Access
Chromatin at the intersection of viral infection and DNA damage
Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms·2009· 46 cited
Mislocalization of the MRN complex prevents ATR signaling during adenovirus infection
The EMBO Journal·2009· 93 citedOpen Access
Global Analysis of Host-Pathogen Interactions that Regulate Early-Stage HIV-1 Replication
Cell·2008· 946 citedOpen Access
Using or abusing: viruses and the cellular DNA damage response
Trends in Microbiology·2007· 211 cited
A Hybrid Vector for Ligand-Directed Tumor Targeting and Molecular Imaging
Cell·2006· 275 cited
APOBEC3A Is a Potent Inhibitor of Adeno-Associated Virus and Retrotransposons
Current Biology·2006· 382 citedOpen Access
DNA repair proteins affect the lifecycle of herpes simplex virus 1
Proceedings of the National Academy of Sciences·2005· 246 citedOpen Access
Interactions of viruses with the cellular DNA repair machinery
DNA repair·2004· 105 cited
Construction of Multiply Disabled Herpes Simplex Viral Vectors for Gene Delivery to the Nervous System
Humana Press eBooks·2003· 2 cited
Deletion of the Virion Host Shutoff Protein (vhs) from Herpes Simplex Virus (HSV) Relieves the Viral Block to Dendritic Cell Activation: Potential of vhs<sup>−</sup>HSV Vectors for Dendritic Cell-Mediated Immunotherapy
Journal of Virology·2003· 116 citedOpen Access
A Protein Encoded by the Herpes Simplex Virus (HSV) Type 1 2-Kilobase Latency-Associated Transcript Is Phosphorylated, Localized to the Nucleus, and Overcomes the Repression of Expression from Exogenous Promoters When Inserted into the Quiescent HSV Genome
Journal of Virology·2002· 47 citedOpen Access
Multiple Immediate-Early Gene-Deficient Herpes Simplex Virus Vectors Allowing Efficient Gene Delivery to Neurons in Culture and Widespread Gene Delivery to the Central Nervous System In Vivo
Journal of Virology·2001· 118 citedOpen Access
In vivo myocardial gene transfer: Optimization, evaluation and direct comparison of gene transfer vectors
Basic Research in Cardiology·2001· 95 cited
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Frequent Co-authors

Matthew D. Weitzman(14), Mira S. Chaurushiya(6), Robert S. Coffin(5), R. S. Coffin(4), Christian T. Carson(3), Chris Boutell(3), D.S. Latchman(3), David S. Latchman(3), Darwin V. Lee(2), Rachel A. Schwartz(2), Sébastien Landry(2), Junghae Suh(2), Roger D. Everett(2), James A. Palmer(2), Filitsa Groutsi(2), Suzanne Thomas(2), Renate König(1), Yingyao Zhou(1), Daniel Elleder(1), Tracy L. Diamond(1)