Bertrand L. Chenard

Neuroscience · Life Sciences

18h-index1.0kcitations34works0.02yr avg
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Research Topics

Neuroscience and Neuropharmacology Research(10), Bioactive Compounds and Antitumor Agents(8), Ion Channels and Receptors(5), Oxidative Organic Chemistry Reactions(5), Receptor Mechanisms and Signaling(4)

Publications34 total

Treatment with HC-070, a potent inhibitor of TRPC4 and TRPC5, leads to anxiolytic and antidepressant effects in mice
PLoS ONE·2018· 135 citedOpen Access
Pyrido[2,3-b]pyrazines, discovery of TRPV1 antagonists with reduced potential for the formation of reactive metabolites
Bioorganic & Medicinal Chemistry Letters·2010· 17 citedOpen Access
Discovery of Novel 6,6-Heterocycles as Transient Receptor Potential Vanilloid (TRPV1) Antagonists
Journal of Medicinal Chemistry·2010· 37 citedOpen Access
C5a, But Not C3a, Increases VEGF Secretion in ARPE-19 Human Retinal Pigment Epithelial Cells
Current Eye Research·2009· 51 cited
ChemInform Abstract: An Efficient Preparation of β‐Aryl‐β‐ketophosphonates by the TFAA/H<sub>3</sub>PO<sub>4</sub>‐Mediated Acylation of Arenes with Phosphonoacetic Acids.
ChemInform·2008
Opportunities and Challenges in the Discovery of New Central Nervous System Drugs
Annals of the New York Academy of Sciences·2008· 4 cited
1-Benzylbenzimidazoles: The discovery of a novel series of bradykinin B1 receptor antagonists
Bioorganic & Medicinal Chemistry Letters·2008· 11 citedOpen Access
An Efficient Preparation of β-Aryl-β-ketophosphonates by the TFAA/H<sub>3</sub>PO<sub>4</sub>-Mediated Acylation of Arenes with Phosphonoacetic Acids
The Journal of Organic Chemistry·2008· 22 cited
Aminoquinazolines as TRPV1 antagonists: Modulation of drug-like properties through the exploration of 2-position substitution
Bioorganic & Medicinal Chemistry Letters·2008· 18 citedOpen Access
Aminopyrazine CB1 receptor inverse agonists
Bioorganic & Medicinal Chemistry Letters·2008· 8 citedOpen Access
Development of a Scaleable Synthesis of NDT 9533750, a Key Intermediate to a Series of Novel Subtype Preferring GABA<sub>A</sub> Partial Agonists
Organic Process Research & Development·2007· 3 cited
Molecular characterization of the gerbil C5a receptor and identification of a transmembrane domain V amino acid that is crucial for small molecule antagonist interaction. VOLUME 280 (2005) PAGES 40617-40623
Journal of Biological Chemistry·2006Open Access
Molecular Characterization of the Gerbil C5a Receptor and Identification of a Transmembrane Domain V Amino Acid That Is Crucial for Small Molecule Antagonist Interaction
Journal of Biological Chemistry·2005· 26 citedOpen Access
G-Protein Coupled Receptor Inverse Agonists: Identification, Pharmacological Relevance and Functional Assays
Annual reports in medicinal chemistry·2005· 3 cited
Transient receptor potential ion channels as targets for the discovery of pain therapeutics.
PubMed·2005· 59 cited
CP-465,022, a Selective Noncompetitive AMPA Receptor Antagonist, Blocks AMPA Receptors but Is Not Neuroprotective In Vivo
Stroke·2003· 30 citedOpen Access
Quinazolin-4-one α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid (AMPA) Receptor Antagonists:  Structure−Activity Relationship of the C-2 Side Chain Tether
Journal of Medicinal Chemistry·2001· 45 cited
Characterization of the Binding Site for a Novel Class of Noncompetitive α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid Receptor Antagonists
Molecular Pharmacology·2000· 49 citedOpen Access
Characterization of the Binding Site for a Novel Class of Noncompetitive α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid Receptor Antagonists
Molecular Pharmacology·2000· 6 cited
CP-101,606, an NR2B subunit selective NMDA receptor antagonist, inhibits NMDA and injury induced c-fos expression and cortical spreading depression in rodents
Neuropharmacology·2000· 56 cited
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Frequent Co-authors

James E. Krause(11), Frank S. Menniti(8), John S. Swenton(8), Daniel N. Cortright(6), Martin J. Pagnozzi(5), William F. White(5), Willard M. Welch(4), Mark T. Kershaw(4), Kevin J. Hodgetts(4), Robbin Brodbeck(4), Alan Hutchison(4), Mary F. Ducat(3), Stephen M. Waters(3), Frank E. Ewing(3), Charles A. Blum(3), Xiaozhang Zheng(3), Rajagopal Bakthavatchalam(3), Marci Crandall(3), George Maynard(3), Zhe‐Qing Wang(3)