Marian Orłowski

Medicine · Health Sciences

53h-index10.9kcitations131works0.02yr avg
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Research Topics

Peptidase Inhibition and Analysis(60), Neuropeptides and Animal Physiology(40), Amino Acid Enzymes and Metabolism(35), Sulfur Compounds in Biology(24), Protease and Inhibitor Mechanisms(17)

Publications131 total

β Synthesis and NLRP3-Mediated IL-1 β IL-1 - Multiple Cathepsins Promote Pro
2015
Targeted inhibition of the immunoproteasome is a potent strategy against models of multiple myeloma that overcomes resistance to conventional drugs and nonspecific proteasome inhibitors
Blood·2008· 206 citedOpen Access
Identification of Novel Inhibitors That Specifically Target the Immunoproteasome, and Selectively Induce Apoptosis in Multiple Myeloma and Other Immunoproteasome-Expressing Model Systems.
Blood·2005· 10 cited
Ubiquitin-independent proteolytic functions of the proteasome
Archives of Biochemistry and Biophysics·2003· 208 cited
Selective Activation of the 20 S Proteasome (Multicatalytic Proteinase Complex) by Histone H3
Biochemistry·2001· 14 cited
[Staphylococcus aureus sepsis--still life threatening disease].
PubMed·2001· 2 cited
Heat Shock Protein-90 and the Catalytic Activities of the 20 S Proteasome (Multicatalytic Proteinase Complex)
Archives of Biochemistry and Biophysics·2001· 20 cited
Catalytic Activities of the 20 S Proteasome, a Multicatalytic Proteinase Complex
Archives of Biochemistry and Biophysics·2000· 301 cited
Components of the Bovine Pituitary Multicatalytic Proteinase Complex (Proteasome) Cleaving Bonds after Hydrophobic Residues
Biochemistry·1999· 30 cited
Tumor growth inhibition induced in a murine model of human Burkitt's lymphoma by a proteasome inhibitor.
PubMed·1998· 279 cited
Dissociation of Proteasomal Degradation of Biosynthesized Viral Proteins from Generation of MHC Class I-Associated Antigenic Peptides
The Journal of Immunology·1998· 60 citedOpen Access
CD4 Glycoprotein Degradation Induced by Human Immunodeficiency Virus Type 1 Vpu Protein Requires the Function of Proteasomes and the Ubiquitin-Conjugating Pathway
Journal of Virology·1998· 261 citedOpen Access
Oddzialywanie nawozow kompleksowych w trzyletnim zmianowaniu na zawartosc N-NH4+, N-NO3- i magnezu w glebie
1998
Reactions of [<sup>14</sup>C]-3,4-Dichloroisocoumarin with Subunits of Pituitary and Spleen Multicatalytic Proteinase Complexes (Proteasomes)
Biochemistry·1997· 34 cited
Two Novel Routes of Transporter Associated with Antigen Processing (TAP)-independent Major Histocompatibility Complex Class I Antigen Processing
The Journal of Experimental Medicine·1997· 91 cited
The generation of MHC class I-associated peptides is only partially inhibited by proteasome inhibitors: involvement of nonproteasomal cytosolic proteases in antigen processing?
The Journal of Immunology·1997· 108 cited
Bovine Spleen Multicatalytic Proteinase Complex (Proteasome)
Journal of Biological Chemistry·1997· 138 citedOpen Access
Enhanced presentation by MHC class I of an influenza nucleoprotein epitope in the presence of proteasome inhibitors
Immunology Letters·1997
Differences in Catalytic Activities and Subunit Pattern of Multicatalytic Proteinase Complexes (Proteasomes) Isolated from Bovine Pituitary, Lung, and Liver
Journal of Biological Chemistry·1995· 31 citedOpen Access
Inhibition of the proteolytic activity of the multicatalytic proteinase complex (proteasome) by substrate-related peptidyl aldehydes.
Journal of Biological Chemistry·1994· 112 citedOpen Access
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Frequent Co-authors

Alton Meister(10), Sherwin Wilk(8), Charlene Michaud(8), Jack R. Bennink(4), Alexander Vinitsky(4), A Szewczuk(4), Christopher J. Molineaux(4), Christopher Cardozo(3), Thomas G. Chu(3), Luis C. Antón(3), Heidi Link Snyder(3), Robert Z. Orlowski(2), Igor Bačík(2), Jonathan W. Yewdell(2), June S. Almenoff(2), Paul G. Richman(2), Adrian R. Pierotti(2), Abraham Lasdun(2), Jairam R. Eswara(1), Anne Lafond-Walker(1)