Toshihisa Koga

Otsuka (Japan) — Japan

Pharmacology, Toxicology and Pharmaceutics · Life Sciences

11h-index452citations19works2.02yr avg
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Research Topics

Pharmacogenetics and Drug Metabolism(6), Drug Transport and Resistance Mechanisms(6), Pharmacological Effects and Toxicity Studies(4), Analytical Methods in Pharmaceuticals(3), Drug-Induced Hepatotoxicity and Protection(3)

Publications19 total

Possible nonimmunological toxicological mechanisms of vesnarinone-associated agranulocytosis in HL-60 cells: role of reduced glutathione as cytotoxic defense
The Journal of Toxicological Sciences·2024· 2 citedOpen Access
Establishment of an <i>in vitro</i> cholestasis risk assessment system using two-dimensional cultured HepaRG cells and 12 bile acids
The Journal of Toxicological Sciences·2023· 3 citedOpen Access
Pharmacokinetics and metabolism of brexpiprazole, a novel serotonin-dopamine activity modulator and its main metabolite in rat, monkey and human
Xenobiotica·2021· 14 citedOpen Access
<i>In vitro</i> evaluations for pharmacokinetic drug-drug interactions of a novel serotonin-dopamine activity modulator, brexpiprazole
Xenobiotica·2021· 11 cited
Pharmacokinetics and metabolism of brexpiprazole, a novel serotonin-dopamine activity modulator and its main metabolite in rat, monkey and human
Figshare·2021Open Access
Evaluation of intestinal metabolism and absorption using the Ussing chamber system equipped with intestinal tissue from rats and dogs
European Journal of Pharmaceutics and Biopharmaceutics·2017· 14 cited
Prediction of drug intestinal absorption in human using the Ussing chamber system: A comparison of intestinal tissues from animals and humans
European Journal of Pharmaceutical Sciences·2016· 41 cited
Liquid Chromatography-Tandem Mass Spectrometry Methods for Determination of Delamanid in Mouse Plasma and Lung
American Journal of Analytical Chemistry·2015· 14 citedOpen Access
Toxicological evaluation of the acyl glucuronide of nonsteroidal anti-inflammatory drugs
한국분석과학회 학술대회·2014
Liquid chromatography–tandem mass spectrometry method for determining tolvaptan and its nine metabolites in rat serum: application to a pharmacokinetic study
Archives of Pharmacal Research·2014· 14 cited
Perspectives on non-clinical safety evaluation of drug metabolites through the JSOT workshop
The Journal of Toxicological Sciences·2012· 6 citedOpen Access
Toxicological Evaluation of Acyl Glucuronides of Nonsteroidal Anti-Inflammatory Drugs Using Human Embryonic Kidney 293 Cells Stably Expressing Human UDP-Glucuronosyltransferase and Human Hepatocytes
Drug Metabolism and Disposition·2010· 48 cited
N-Glycosylation plays a role in protein folding of human UGT1A9
Biochemical Pharmacology·2009· 41 citedOpen Access
The Uracil Breath Test in the Assessment of Dihydropyrimidine Dehydrogenase Activity: Pharmacokinetic Relationship between Expired 13CO2 and Plasma [2-13C]Dihydrouracil
Clinical Cancer Research·2006· 76 cited
Physiologically based pharmacokinetic modelling of the three‐step metabolism of pyrimidine using<sup>13</sup>C‐uracil as an<i>in vivo</i>probe
British Journal of Clinical Pharmacology·2005· 27 citedOpen Access
High performance liquid chromatographic methods for the determination of aripiprazole with ultraviolet detection in rat plasma and brain: Application to the pharmacokinetic study
Journal of Chromatography B·2005· 74 cited
RELATIONSHIPS AMONG PLASMA [2-13C]URACIL CONCENTRATIONS, BREATH 13CO2 EXPIRATION, AND DIHYDROPYRIMIDINE DEHYDROGENASE (DPD) ACTIVITY IN THE LIVER IN NORMAL AND DPD-DEFICIENT DOGS
Drug Metabolism and Disposition·2004· 11 cited
Mechanism of Hydroxyl Radical Scavenging by Rebamipide: Identification of Mono-hydroxylated Rebamipide as a Major Reaction Product
Free Radical Research·2004· 56 cited
and DPD activity in the liver in normal and DPD-deficient dogs
2004

Frequent Co-authors

Yukihiro Hirao(8), Kenji Takeuchi(5), Ken Umehara(5), Takefumi Shimizu(4), Eiji Kashiyama(4), Hiroyuki Sasabe(4), Masayuki Furukawa(4), Miki Nakajima(3), Tsuyoshi Yokoi(3), Makoto Inada(3), Jun‐ichi Kunizaki(3), Masayuki Matsunaga(3), Yosuke Kaneko(3), Noriyuki Koyama(3), Yoshihiko Shimokawa(2), Ryoichi Fujiwara(2), Masateru Miyake(2), Satoshi Kondo(2), Noriaki Yoda(2), Chie Emoto(2)