Takefumi Shimizu

University of Yamanashi — Japan

Pharmacology, Toxicology and Pharmaceutics · Life Sciences

13h-index502citations34works0.02yr avg
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Research Topics

Pharmacogenetics and Drug Metabolism(5), Analytical Methods in Pharmaceuticals(5), Drug Transport and Resistance Mechanisms(4), Antibiotics Pharmacokinetics and Efficacy(4), Cancer therapeutics and mechanisms(4)

Publications34 total

AV block monkey can predict proarrhythmic risk of moxifloxacin: Comparison of the results with those from clinical study
Journal of Pharmacological and Toxicological Methods·2008
Comparison of Inducibility of Sulfotransferase and UDP-Glucuronosyltransferase mRNAs by Prototypical Microsomal Enzyme Inducers in Primary Cultures of Human and Cynomolgus Monkey Hepatocytes
Drug Metabolism and Pharmacokinetics·2008· 19 cited
Functional characterization of human and cynomolgus monkey cytochrome P450 2E1 enzymes
Life Sciences·2007· 13 cited
Comparison of Inducibility of CYP1A and CYP3A mRNAs by Prototypical Inducers in Primary Cultures of Human, Cynomolgus Monkey, and Rat Hepatocytes
Drug Metabolism and Pharmacokinetics·2007· 71 cited
Functional characterization of human and cynomolgus monkey UDP-glucuronosyltransferase 1A6 enzymes
Chemico-Biological Interactions·2006· 18 cited
Effects of prototypical drug-metabolizing enzyme inducers on mRNA expression of housekeeping genes in primary cultures of human and rat hepatocytes
Biochemical and Biophysical Research Communications·2006· 35 cited
The Uracil Breath Test in the Assessment of Dihydropyrimidine Dehydrogenase Activity: Pharmacokinetic Relationship between Expired 13CO2 and Plasma [2-13C]Dihydrouracil
Clinical Cancer Research·2006· 76 cited
Determination of Dihydropyrimidine Dehydrogenase Activity in Human Peripheral Blood Mononuclear Cells by Radio-HPLC Method
BUNSEKI KAGAKU·2006Open Access
Physiologically based pharmacokinetic modelling of the three‐step metabolism of pyrimidine using<sup>13</sup>C‐uracil as an<i>in vivo</i>probe
British Journal of Clinical Pharmacology·2005· 27 citedOpen Access
RELATIONSHIPS AMONG PLASMA [2-13C]URACIL CONCENTRATIONS, BREATH 13CO2 EXPIRATION, AND DIHYDROPYRIMIDINE DEHYDROGENASE (DPD) ACTIVITY IN THE LIVER IN NORMAL AND DPD-DEFICIENT DOGS
Drug Metabolism and Disposition·2004· 11 cited
and DPD activity in the liver in normal and DPD-deficient dogs
2004
Stereospecific and simultaneous high-performance liquid chromatographic assay of flosequinan and its metabolites in human plasma
Journal of Chromatography B Biomedical Sciences and Applications·1994· 6 cited
Synthesis and Absolute Configuration of the Enantiomers of 7-Fluoro-1-methyl-3-(methylsulfinyl)-4(1H)-quinolinone (Flosequinan).
Chemical and Pharmaceutical Bulletin·1994· 5 citedOpen Access
Highly sensitive method for the determination of 5-fluorouracil in biological samples in the presence of 2'-deoxy-5-fluorouridine by gas chromatography—mass spectrometry
Journal of Chromatography B Biomedical Sciences and Applications·1991· 17 cited
COMPARATIVE PHARMACOKINETICS OF INTERLEUKIN-1 β SER^ AND INTERFERON-γ
Journal of Pharmacobio-Dynamics·1991
EFFECTS OF OCT-43 (rIL-1 β Ser^ ) ON RAT LIVER DRUG METABOLIZING ENZYMES
Journal of Pharmacobio-Dynamics·1991
Synthesis and Antiulcer Activity of Optical Isomers of 2-(4-Chlorobenzoylamino)-3-(2(1H)-quinolinon-4-yl)propionic Acid (Rebamipide).
Chemical and Pharmaceutical Bulletin·1991· 21 citedOpen Access
Haemodynamics and Pharmacokineticsof Flosequinan (BTS 49 465) after Single and Multiple Oral Administration in Healthy Volunteers.
Rinsho yakuri/Japanese Journal of Clinical Pharmacology and Therapeutics·1991· 3 citedOpen Access
IN VITRO DEGRADATION OF OCT-43 (rIL-1β Ser^ ) BY RAT KIDNEY LYSOSOMES
Journal of Pharmacobio-Dynamics·1990
The distribution of OPC-7251 in the skin.
Drug Metabolism and Pharmacokinetics·1990· 1 citedOpen Access
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Frequent Co-authors

Masaaki Odomi(8), Shizuo Narimatsu(5), Shinsaku Naito(5), KAZUYUKI NAKAGAWA(5), Yukihiro Hirao(4), Toshihisa Koga(4), Akiko Koeda(4), Takao Nishi(4), Toshimi Kanbe(4), Makoto Inada(4), Gohachiro Miyamoto(4), Masuhiro Nishimura(3), Mitsuo Nakayama(3), Tetsuo Satoh(3), Fujio Tabusa(3), Tatsuyoshi Tanaka(3), Yukio Kimura(3), Jun‐ichi Kunizaki(3), Seiji Morita(3), Minoru Uchida(3)