Rafael Fridman

Wayne State University — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

33h-index6.5kcitations67works0.02yr avg
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Research Topics

Protease and Inhibitor Mechanisms(29), Cell Adhesion Molecules Research(24), Peptidase Inhibition and Analysis(20), Proteoglycans and glycosaminoglycans research(9), Monoclonal and Polyclonal Antibodies Research(8)

Publications67 total

Abstract A049: Collagen-driven kinome reprogramming reveals unique, actionable DDR1-signaling dependencies in pancreatic cancer cells
Cancer Research·2024
Molecular regulation of endothelial and vascular dysfunction by lipid lactone mediators
Atherosclerosis·2023Open Access
Expression and Subcellular Localization of Discoidin Domain Receptor 1 (DDR1) Define Prostate Cancer Aggressiveness
2021Open Access
Discoidin Domain Receptors in Melanoma: Potential Therapeutic Targets to Overcome MAPK Inhibitor Resistance
Frontiers in Oncology·2020· 10 citedOpen Access
Live cell measurements of interaction forces and binding kinetics between Discoidin Domain Receptor 1 (DDR1) and collagen I with atomic force microscopy
Biochimica et Biophysica Acta (BBA) - General Subjects·2019· 13 cited
Abstract 4499: Determining the role of discoidin domain receptors 1 and 2 in the pathogenesis of pancreatic ductal adenocarcinoma
Cancer Research·2018
Discoidin Domain Receptors: Novel Targets in Breast Cancer Bone Metastasis
2017
Targeting Discoidin Domain Receptors in Prostate Cancer
2016
Measurement of DDR-Collagen interaction Forces with Atomic force Microscopy
Bulletin of the American Physical Society·2015
Increased initiation and growth of tumor cell lines, cancer stem cells and biopsy material in mice using basement membrane matrix protein (Cultrex or Matrigel) co-injection
Nature Protocols·2012· 101 cited
Regulation of Discoidin Domain Receptor‐1 by Membrane‐type 1 Matrix Metalloproteinase (MT1‐MMP)
The FASEB Journal·2011
A Tale of a Tail - making Sense of the Shape of Rupture Force Distributions in Single Protein Dissociation Measurements
Biophysical Journal·2011Open Access
Dissociation Kinetics of an Enzyme−Inhibitor System Using Single-Molecule Force Measurements
Biomacromolecules·2010· 11 cited
TIMP-1 induces an epithelial mesenchymal transition via upregulation of the transcription factor Twist in human breast epithelial cells
Cancer Research·2008
MT4-(MMP17) and MT6-MMP (MMP25), A unique set of membrane-anchored matrix metalloproteinases: properties and expression in cancer
Cancer and Metastasis Reviews·2008· 143 citedOpen Access
Functional expression of recombinant human stefin A in mammalian and bacterial cells
Protein Expression and Purification·2006· 4 citedOpen Access
Synthesis of an Inhibitor-Tethered Resin for Detection of Active Matrix Metalloproteinases Involved in Disease
The Journal of Organic Chemistry·2006· 25 cited
434: Membrane Type-1 Matrix Metalloproteinase (MT1-MMP) Promotes Tumor Growth and Bone Degradation in Prostate Cancer Bone Metastasis
The Journal of Urology·2006
Specific MT1-MMP silencing reduces prostate cancer cell proliferation and bone matrix degradation
Cancer Research·2005
Matrix metalloproteinase inhibition impairs the processing, formation and mineralization of dental tissues during mouse molar development
Experimental Cell Research·2005· 101 cited
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Frequent Co-authors

Israël Vlodavsky(11), Hynda K. Kleinman(7), Suzanne Ménashi(5), Reuven Reich(5), Zvi Fuks(5), Márta Tóth(4), William G. Stetler‐Stevenson(4), Anjum Sohail(4), R. Daniel Bonfil(4), Michael Klagsbrun(3), Shahriar Mobashery(3), Robert E. Bird(3), Thomas R. Fuerst(3), Lance A. Liotta(3), George R. Martin(3), Thomas M. Sweeney(3), Mona Zain(3), Amiram Eldor(3), R. S. Berk(3), Y Legrand(3)