Rongguo Qiu

Sinovac Biotech — China

Medicine · Health Sciences

16h-index3.0kcitations29works0.52yr avg
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Research Topics

Cancer Treatment and Pharmacology(10), Protein Kinase Regulation and GTPase Signaling(8), Microbial Natural Products and Biosynthesis(7), Cellular Mechanics and Interactions(3), HER2/EGFR in Cancer Research(3)

Publications29 total

Utidelone Plus Bevacizumab for <i>ERBB2</i>-Negative Metastatic Breast Cancer and Active Brain Metastases
JAMA Oncology·2025· 2 cited
Effcacy and safety results of a multi-center phase I/II study of utidelone capsule, a novel oral microtubule inhibitor.
Journal of Clinical Oncology·2025
A genetically engineered epothilone analog as a novel oral microtubule inhibitor: A clinical study of utidelone capsule for advanced breast cancer.
Journal of Clinical Oncology·2024
A novel oral microtubule inhibitor utidelone capsule (UTD2): A phase 1 clinical study to assess the tolerability, safety, and efficacy in advanced solid tumors.
Journal of Clinical Oncology·2024
Utidelone plus capecitabine versus capecitabine alone for heavily pretreated metastatic breast cancer refractory to anthracyclines and taxanes: a multicentre, open-label, superiority, phase 3, randomised controlled trial
The Lancet Oncology·2017· 55 cited
Phase II trial of utidelone as monotherapy or in combination with capecitabine in heavily pretreated metastatic breast cancer patients
Journal of Hematology & Oncology·2016· 27 citedOpen Access
Concentration-dependent differential effects of an epothilone analog on cell cycle and p53 signaling
Oncology Reports·2015· 3 citedOpen Access
Construction of the co-expression plasmids of fostriecin polyketide synthases and heterologous expression in<i>Streptomyces</i>
Pharmaceutical Biology·2014· 12 citedOpen Access
Seamless stitching of biosynthetic gene cluster containing type I polyketide synthases using Red/ET mediated recombination for construction of stably co-existing plasmids
Gene·2014· 3 cited
Phase II clinical studies of UTD1, an epothilone analog, in metastatic breast cancer.
Journal of Clinical Oncology·2014
Multiple Effects of a Novel Epothilone Analog on Cellular Processes and Signaling Pathways Regulated by Rac1 GTPase in the Human Breast Cancer Cells
Korean Journal of Physiology and Pharmacology·2014· 9 citedOpen Access
Identification of the Post-Polyketide Synthase Modification Enzymes for Fostriecin Biosynthesis in <i>Streptomyces pulveraceus</i>
Journal of Natural Products·2013· 12 cited
Elucidation of the Biosynthetic Gene Cluster and the Post-PKS Modification Mechanism for Fostriecin in Streptomyces pulveraceus
Chemistry & Biology·2013· 32 cited
Tautomycetin Induces Apoptosis by Inactivating Akt Through a PP1-Independent Signaling Pathway in Human Breast Cancer Cells
Journal of Pharmacological Sciences·2012· 15 citedOpen Access
Functional characterization of the genes tauO, tauK, and tauI in the biosynthesis of tautomycetin
The Journal of Microbiology·2012· 6 cited
Differential Effects of Tautomycetin and Its Derivatives on Protein Phosphatase Inhibition, Immunosuppressive Function and Antitumor Activity
Korean Journal of Physiology and Pharmacology·2012· 7 citedOpen Access
Phase I clinical and pharmacokinetic study of UTD1, a genetically engineered epothilone analog in patients with advanced solid tumors
Cancer Chemotherapy and Pharmacology·2011· 27 cited
Generation of Novel Epothilone Analogs with Cytotoxic Activity by Biotransformation.
The Journal of Antibiotics·2003· 22 citedOpen Access
A New Cytotoxic Epothilone from Modified Polyketide Synthases Heterologously Expressed in <i>Myxococcus </i><i>x</i><i>anthus</i>
Journal of Natural Products·2002· 52 cited
Synaptojanin 2, a novel Rac1 effector that regulates clathrin-mediated endocytosis
Current Biology·2000· 136 citedOpen Access
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Frequent Co-authors

Li Tang(15), Marc Symons(8), Pin Zhang(5), Frank McCormick(3), Zhongsheng Tong(3), Yongsheng Wang(3), Binghe Xu(3), Rixiang Kong(3), Xuejiao Liu(3), Chun Su(3), Mingshan Niu(3), Li Tang(3), Binghe Xu(3), David H. Kirn(2), Arie Abo(2), Maikel P. Peppelenbosch(2), Leon G.J. Tertoolen(2), Siegfried W. de Laat(2), Johannes L. Bos(2), Annette H. Ross(2)