Michelle Kelleher

Oxford BioMedica (United Kingdom) — United Kingdom

Biochemistry, Genetics and Molecular Biology · Life Sciences

14h-index1.3kcitations26works0.02yr avg
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Research Topics

Virus-based gene therapy research(8), Retinal Development and Disorders(6), Retinal Diseases and Treatments(5), Immunotherapy and Immune Responses(5), T-cell and B-cell Immunology(2)

Publications26 total

Gene Therapy for Parkinson’s Disease: Preclinical Evaluation of Optimally Configured TH:CH1 Fusion for Maximal Dopamine Synthesis
Molecular Therapy — Methods & Clinical Development·2019· 23 citedOpen Access
Safety and Efficacy of OXB-202, a Genetically Engineered Tissue Therapy for the Prevention of Rejection in High-Risk Corneal Transplant Patients
Human Gene Therapy·2018· 12 cited
Lentiviral Vector Gene Transfer of Endostatin/Angiostatin for Macular Degeneration (GEM) Study
Human Gene Therapy·2016· 179 citedOpen Access
Phase I Safety and Tolerability results for RetinoStat®, a Lentiviral Vector Expressing Endostatin and Angiostatin, in Patients with Advanced Neovascular Age-Related Macular Degeneration
Investigative Ophthalmology & Visual Science·2016· 2 citedOpen Access
33. Advancing a State of the Art Gene Therapy Called OXB-202 That Resists Corneal Rejection in High Risk Patients
Molecular Therapy·2016Open Access
Results from the Phase I GEM study, evaluating safety and tolerability of subretinally-injected lentiviral vector (RetinoStat®) for the treatment of wet age-related macular degeneration (AMD)
2015· 1 cited
200. Advancing a State of the Art Gene Therapy for Parkinson's Disease
Molecular Therapy·2015· 1 citedOpen Access
EIAV-Based Retinal Gene Therapy in the shaker1 Mouse Model for Usher Syndrome Type 1B: Development of UshStat
PLoS ONE·2014· 102 citedOpen Access
Long-term safety and tolerability of ProSavin, a lentiviral vector-based gene therapy for Parkinson's disease: a dose escalation, open-label, phase 1/2 trial
The Lancet·2014· 433 cited
Transduction of Photoreceptors With Equine Infectious Anemia Virus Lentiviral Vectors: Safety and Biodistribution of StarGen for Stargardt Disease
Investigative Ophthalmology & Visual Science·2013· 108 citedOpen Access
Safety and Biodistribution of an Equine Infectious Anemia Virus-Based Gene Therapy, RetinoStat <sup>®</sup> , for Age-Related Macular Degeneration
Human Gene Therapy·2012· 63 cited
Analysis of pre-treatment markers predictive of treatment benefit for the therapeutic cancer vaccine MVA-5T4 (TroVax)
Cancer Immunology Immunotherapy·2012· 30 citedOpen Access
LentiVector® Platform, a Highly Effective Equine Infectious Anaemia Virus-based Lentiviral Gene Therapy Platform for Ocular Disease
Investigative Ophthalmology & Visual Science·2012· 1 cited
Biodistribution and Immunological Response of the Subretinally Injected Lentiviral-Vector StarGenTM in Rabbits and Macaques
Investigative Ophthalmology & Visual Science·2011
Biodistribution and Immunological Responses to the Lentiviral-Vector Based Gene Therapy Product RetinoStat® Following Subretinal Injection in Rabbits and Rhesus Macaques
Investigative Ophthalmology & Visual Science·2011
MVA–5T4-induced immune responses are an early marker of efficacy in renal cancer patients
Cancer Immunology Immunotherapy·2011· 35 citedOpen Access
Comparative Kinetics of Immune Responses and Changes in Cellular Sub-Sets Detected in Colorectal Cancer Patients Vaccinated with MVA-5T4 (TroVax) Administered Alongside Two Different Chemotherapy Regimens
Journal of Cancer Therapy·2011Open Access
A Stable Producer Cell Line for the Manufacture of a Lentiviral Vector for Gene Therapy of Parkinson's Disease
Human Gene Therapy·2010· 41 cited
Cross-trial Analysis of Immunologic and Clinical Data Resulting From Phase I and II Trials of MVA-5T4 (TroVax) in Colorectal, Renal, and Prostate Cancer Patients
Journal of Immunotherapy·2010· 36 cited
Water and Watersheds Research: Discovery and Broader Impacts
Journal of Contemporary Water Research & Education·2007· 1 citedOpen Access
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Frequent Co-authors

Kyriacos Mitrophanous(13), Julie Loader(11), Scott Ellis(10), Richard Harrop(9), Stuart Naylor(9), Katie Binley(8), Jackie de Belin(8), James Miskin(7), Peter Widdowson(5), Georgina Ferrige(4), Marie Carlucci(4), William Shingler(4), Stéphane Palfi(3), G. Ralph(3), Peter A. Campochiaro(3), Andreas Lauer(3), Elliott H. Sohn(3), Diana Angell-Manning(3), Yatish Lad(3), Hannah J. Stewart(3)