Ralph T. Mosley

Biochemistry, Genetics and Molecular Biology · Life Sciences

31h-index3.1kcitations63works0.02yr avg
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Research Topics

Estrogen and related hormone effects(20), Hepatitis C virus research(10), Chemical Synthesis and Analysis(7), Receptor Mechanisms and Signaling(7), HIV/AIDS drug development and treatment(6)

Publications63 total

Correction to Nucleoside, Nucleotide, and Non-Nucleoside Inhibitors of Hepatitis C Virus NS5B RNA-Dependent RNA-Polymerase
Journal of Medicinal Chemistry·2017· 1 cited
Molecular and Structural Basis for the Roles of Hepatitis C Virus Polymerase NS5B Amino Acids 15, 223, and 321 in Viral Replication and Drug Resistance
Antimicrobial Agents and Chemotherapy·2014· 10 citedOpen Access
Discovery of a Novel Class of Potent HCV NS4B Inhibitors: SAR Studies on Piperazinone Derivatives
Journal of Medicinal Chemistry·2014· 53 cited
Use of 2′-Spirocyclic Ethers in HCV Nucleoside Design
Journal of Medicinal Chemistry·2013· 41 citedOpen Access
Structure of Hepatitis C Virus Polymerase in Complex with Primer-Template RNA
Journal of Virology·2012· 116 citedOpen Access
Apo crystal structure of HCV NS5B genotype 2A JFH-1 isolate with beta hairpin loop deletion
2012
Inhibition of hepatitis C virus NS5A by fluoro-olefin based γ-turn mimetics
Bioorganic & Medicinal Chemistry Letters·2012· 60 cited
CCDC 866508: Experimental Crystal Structure Determination
The Cambridge Structural Database·2012Open Access
Nucleoside, Nucleotide, and Non-Nucleoside Inhibitors of Hepatitis C Virus NS5B RNA-Dependent RNA-Polymerase
Journal of Medicinal Chemistry·2011· 275 cited
Benzimidazolones: A New Class of Selective Peroxisome Proliferator-Activated Receptor γ (PPARγ) Modulators
Journal of Medicinal Chemistry·2011· 56 citedOpen Access
Adenosine Deaminase-like Protein 1 (ADAL1): Characterization and Substrate Specificity in the Hydrolysis of N<sup>6</sup>- or O<sup>6</sup>-Substituted Purine or 2-Aminopurine Nucleoside Monophosphates
Journal of Medicinal Chemistry·2011· 39 cited
Phenylpropenamide derivatives: Anti-hepatitis B virus activity of the Z isomer, SAR and the search for novel analogs
Bioorganic & Medicinal Chemistry Letters·2011· 45 cited
CCDC 701313: Experimental Crystal Structure Determination
The Cambridge Structural Database·2009Open Access
The synthesis and conformational analysis of amino acid–tetrahydroanthranilic acid hybrids
Tetrahedron Letters·2008· 11 cited
Identification of small molecule estrogen‐related receptor α–specific antagonists and homology modeling to predict the molecular determinants as the basis for selectivity over ERRβ and ERRγ
Drug Development Research·2008· 17 cited
The Differential Interactions of Peroxisome Proliferator-Activated Receptor γ Ligands with Tyr473 Is a Physical Basis for Their Unique Biological Activities
Molecular Pharmacology·2007· 73 cited
Androstene-3,5-dienes as ER-β selective SERMs
Bioorganic & Medicinal Chemistry Letters·2007· 10 citedOpen Access
The discovery of 6-amino nicotinamides as potent and selective histone deacetylase inhibitors
Bioorganic & Medicinal Chemistry Letters·2007· 43 citedOpen Access
Benzo[b]thiophene-based histone deacetylase inhibitors
Bioorganic & Medicinal Chemistry Letters·2007· 38 citedOpen Access
Novel glucocorticoids containing a 6,5-bicyclic core fused to a pyrazole ring: Synthesis, in vitro profile, molecular modeling studies, and in vivo experiments
Bioorganic & Medicinal Chemistry Letters·2007· 19 citedOpen Access
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Frequent Co-authors

Elizabeth T. Birzin(15), Susan P. Rohrer(14), Milton L. Hammond(12), Wanda Chan(9), James M. Schaeffer(9), Michael J. Sofia(9), Phillip A. Furman(8), Edward C. Hayes(6), Angela M. Lam(5), Yi Yang(5), Frank DiNinno(5), Timothy A. Blizzard(5), Arthur A. Patchett(4), Kevin T. Chapman(4), Wonsuk Chang(4), Robert P. Sheridan(4), Michaël Otto(4), Katalin Frisch(4), Lee-Yuh Pai(4), Paula M.D. Fitzgerald(4)