Phillip A. Furman

Saint Augustine's University — United States

Medicine · Health Sciences

38h-index6.6kcitations95works0.02yr avg
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Research Topics

HIV/AIDS drug development and treatment(56), Hepatitis C virus research(44), Hepatitis B Virus Studies(27), Biochemical and Molecular Research(23), HIV Research and Treatment(20)

Publications95 total

The Discovery of Sofosbuvir: A Liver-Targeted Nucleotide Prodrug for the Treatment and Cure of HCV
Topics in medicinal chemistry·2019· 11 cited
Correction to Nucleoside, Nucleotide, and Non-Nucleoside Inhibitors of Hepatitis C Virus NS5B RNA-Dependent RNA-Polymerase
Journal of Medicinal Chemistry·2017· 1 cited
2-Acetylpyridine 5-((dimethylamino)thiocarbonyl)- thiocarbonohydrazone (AlllOU), a potent inactivator of ribonucleotide reductases of herpes simplex and varicella-zoster viruses and a potentiator of acyclovir (antiviral chemotherapy/drug potentiation)
2017
Editorial overview: Anti-infectives
Current Opinion in Pharmacology·2016Open Access
CCDC 1426215: Experimental Crystal Structure Determination
The Cambridge Structural Database·2015Open Access
Molecular and Structural Basis for the Roles of Hepatitis C Virus Polymerase NS5B Amino Acids 15, 223, and 321 in Viral Replication and Drug Resistance
Antimicrobial Agents and Chemotherapy·2014· 10 citedOpen Access
Discovery of a Novel Class of Potent HCV NS4B Inhibitors: SAR Studies on Piperazinone Derivatives
Journal of Medicinal Chemistry·2014· 53 cited
Noncompetitive Inhibition of Hepatitis B Virus Reverse Transcriptase Protein Priming and DNA Synthesis by the Nucleoside Analog Clevudine
Antimicrobial Agents and Chemotherapy·2013· 1 citedOpen Access
Use of 2′-Spirocyclic Ethers in HCV Nucleoside Design
Journal of Medicinal Chemistry·2013· 41 citedOpen Access
Noncompetitive Inhibition of Hepatitis B Virus Reverse Transcriptase Protein Priming and DNA Synthesis by the Nucleoside Analog Clevudine
Antimicrobial Agents and Chemotherapy·2013· 41 citedOpen Access
β-d-2′-α-F-2′-β-C-Methyl-6-O-substituted 3′,5′-cyclic phosphate nucleotide prodrugs as inhibitors of hepatitis C virus replication: A structure–activity relationship study
Bioorganic & Medicinal Chemistry Letters·2012· 17 cited
Metabolic Activation of the Anti-Hepatitis C Virus Nucleotide Prodrug PSI-352938
Antimicrobial Agents and Chemotherapy·2012· 24 citedOpen Access
A 2′-Deoxy-2′-Fluoro-2′-C-Methyl Uridine Cyclopentyl Carbocyclic Analog and Its Phosphoramidate Prodrug as Inhibitors of HCV NS5B Polymerase
Nucleosides Nucleotides & Nucleic Acids·2012· 14 cited
Genotype and Subtype Profiling of PSI-7977 as a Nucleotide Inhibitor of Hepatitis C Virus
Antimicrobial Agents and Chemotherapy·2012· 241 citedOpen Access
Inhibition of hepatitis C virus NS5A by fluoro-olefin based γ-turn mimetics
Bioorganic & Medicinal Chemistry Letters·2012· 60 cited
Phosphoramidate Prodrugs of (−)-β-D-(2R,4R)-dioxolane-thymine (DOT) as Potent Anti-HIV Agents
Antiviral chemistry & chemotherapy·2012· 9 citedOpen Access
Nucleoside, Nucleotide, and Non-Nucleoside Inhibitors of Hepatitis C Virus NS5B RNA-Dependent RNA-Polymerase
Journal of Medicinal Chemistry·2011· 275 cited
Synthesis of Stable Isotope Labeled Analogs of the Anti-Hepatitis C Virus Nucleotide Prodrugs PSI-7977 and PSI-352938
Nucleosides Nucleotides & Nucleic Acids·2011· 4 cited
Hepatitis C Virus Nucleotide Inhibitors PSI-352938 and PSI-353661 Exhibit a Novel Mechanism of Resistance Requiring Multiple Mutations within Replicon RNA
Journal of Virology·2011· 55 cited
Adenosine Deaminase-like Protein 1 (ADAL1): Characterization and Substrate Specificity in the Hydrolysis of N<sup>6</sup>- or O<sup>6</sup>-Substituted Purine or 2-Aminopurine Nucleoside Monophosphates
Journal of Medicinal Chemistry·2011· 39 cited
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Frequent Co-authors

Michaël Otto(19), Michael J. Sofia(14), Angela M. Lam(14), Holly M. Micolochick Steuer(13), Shalini Bansal(12), Congrong Niu(12), Wonsuk Chang(10), Christine Espiritu(10), Meg Keilman(9), Haiying Bao(9), Raymond F. Schinazi(8), Jinfa Du(7), Eisuke Murakami(7), James A. Fyfe(6), Bruce S. Ross(6), Ralph T. Mosley(6), Gertrude B. Elion(5), Donghui Bao(5), Dhanapalan Nagarathnam(5), P. Ganapati Reddy(5)