Judith L. Treadway

Northwestern University — United States

Medicine · Health Sciences

35h-index3.6kcitations78works0.02yr avg
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Research Topics

Pancreatic function and diabetes(21), Metabolism, Diabetes, and Cancer(19), Glycogen Storage Diseases and Myoclonus(17), Diabetes Treatment and Management(13), Carbohydrate Chemistry and Synthesis(10)

Publications78 total

Evolution of Antibiotic Resistance in Patients with Pseudomonas Aeruginosa Pneumonia in the ICU
2019
a glycogen phosphorylase Integrated effects of multiple modulators on human liver
2016
The design and synthesis of a potent glucagon receptor antagonist with favorable physicochemical and pharmacokinetic properties as a candidate for the treatment of type 2 diabetes mellitus
Bioorganic & Medicinal Chemistry Letters·2013· 40 citedOpen Access
In Vivo Imaging of Endogenous Pancreatic β-Cell Mass in Healthy and Type 1 Diabetic Subjects Using <sup>18</sup>F-Fluoropropyl-Dihydrotetrabenazine and PET
Journal of Nuclear Medicine·2012· 114 citedOpen Access
Discovery of (<i>S</i>)-6-(3-Cyclopentyl-2-(4-(trifluoromethyl)-1<i>H</i>-imidazol-1-yl)propanamido)nicotinic Acid as a Hepatoselective Glucokinase Activator Clinical Candidate for Treating Type 2 Diabetes Mellitus
Journal of Medicinal Chemistry·2011· 114 citedOpen Access
Modeling the Mechanism of Action of a DGAT1 Inhibitor Using a Causal Reasoning Platform
PLoS ONE·2011· 33 citedOpen Access
Islet-selectivity of G-protein coupled receptor ligands evaluated for PET imaging of pancreatic β-cell mass
Biochemical and Biophysical Research Communications·2011· 24 cited
Defective Glycogenesis Contributes Toward the Inability to Suppress Hepatic Glucose Production in Response to Hyperglycemia and Hyperinsulinemia in Zucker Diabetic Fatty Rats
Diabetes·2011· 22 citedOpen Access
Polyomic profiling reveals significant hepatic metabolic alterations in glucagon-receptor (GCGR) knockout mice: implications on anti-glucagon therapies for diabetes
BMC Genomics·2011· 82 citedOpen Access
Impact of a Glycogen Phosphorylase Inhibitor and Metformin on Basal and Glucagon-Stimulated Hepatic Glucose Flux in Conscious Dogs
Journal of Pharmacology and Experimental Therapeutics·2011· 41 citedOpen Access
1-((3S,4S)-4-Amino-1-(4-substituted-1,3,5-triazin-2-yl) pyrrolidin-3-yl)-5,5-difluoropiperidin-2-one inhibitors of DPP-4 for the treatment of type 2 diabetes
Bioorganic & Medicinal Chemistry Letters·2011· 20 citedOpen Access
Designing glucokinase activators with reduced hypoglycemia risk: discovery of N,N-dimethyl-5-(2-methyl-6-((5-methylpyrazin-2-yl)-carbamoyl)benzofuran-4-yloxy)pyrimidine-2-carboxamide as a clinical candidate for the treatment of type 2 diabetes mellitus
MedChemComm·2011· 68 cited
Pancreatic Beta Cell Mass PET Imaging and Quantification with [11C]DTBZ and [18F]FP-(+)-DTBZ in Rodent Models of Diabetes
Molecular Imaging and Biology·2010· 55 citedOpen Access
The Application of Target Information and Preclinical Pharmacokinetic/Pharmacodynamic Modeling in Predicting Clinical Doses of a Dickkopf-1 Antibody for Osteoporosis
Journal of Pharmacology and Experimental Therapeutics·2010· 99 cited
Piperidinyl-2-phenethylamino inhibitors of DPP-IV for the treatment of Type 2 diabetes
Bioorganic & Medicinal Chemistry Letters·2009· 8 citedOpen Access
(3,3-Difluoro-pyrrolidin-1-yl)-[(2S,4S)-(4-(4-pyrimidin-2-yl-piperazin-1-yl)-pyrrolidin-2-yl]-methanone: A potent, selective, orally active dipeptidyl peptidase IV inhibitor
Bioorganic & Medicinal Chemistry Letters·2009· 43 citedOpen Access
CCDC 724858: Experimental Crystal Structure Determination
The Cambridge Structural Database·2009Open Access
Poster Session 1 Selected Posters from 169‐P through 466‐P
Obesity·2008Open Access
The hepatic PP1 glycogen‐targeting subunit interaction with phosphorylase <i>a</i> can be blocked by C‐terminal tyrosine deletion or an indole drug
FEBS Letters·2007· 27 citedOpen Access
(3R,4S)-4-(2,4,5-Trifluorophenyl)-pyrrolidin-3-ylamine inhibitors of dipeptidyl peptidase IV: Synthesis, in vitro, in vivo, and X-ray crystallographic characterization
Bioorganic & Medicinal Chemistry Letters·2007· 16 citedOpen Access
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Frequent Co-authors

R. Kirk McPherson(13), E. Michael Gibbs(10), Jeffrey E. Pessin(10), Dennis E. Danley(7), Dennis J. Hoover(6), Carolyn B. Levy(6), Walter C. Soeller(6), Mark Ammirati(5), William J. Zavadoski(5), Stephen W. Wright(5), Lester D. McClure(5), Virginia L. Rath(4), Shenping Liu(4), Anne L. Frattali(4), David Hageman(4), Kim Andrews(4), William H. Martin(3), Alan M. Mathiowetz(3), Gary W. Cline(3), Jeffrey A. Pfefferkorn(3)