Edgar F. da Cruz e Silva

University of Aveiro — Portugal

Medicine · Health Sciences

24h-index1.9kcitations51works0.02yr avg
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Research Topics

Alzheimer's disease research and treatments(23), Cellular transport and secretion(9), Microtubule and mitosis dynamics(7), Ubiquitin and proteasome pathways(7), RNA Research and Splicing(6)

Publications51 total

BRI2 and BRI3 are functionally distinct phosphoproteins
Cellular Signalling·2015· 17 cited
Protein phosphatase 1 is a key player in nuclear events
Cellular Signalling·2015· 77 cited
Genetic mutations strengthen functional association of LAP1 with DYT1 dystonia and muscular dystrophy
Mutation Research/Reviews in Mutation Research·2015· 19 cited
Characterisation of several ankyrin repeat protein variant 2, a phosphoprotein phosphatase 1-interacting protein, in testis and spermatozoa
Reproduction Fertility and Development·2015· 3 cited
Identification of a Novel Human LAP1 Isoform That Is Regulated by Protein Phosphorylation
PLoS ONE·2014· 43 citedOpen Access
LAP1 is a crucial protein for the maintenance of the nuclear envelope structure and cell cycle progression
Molecular and Cellular Biochemistry·2014· 32 cited
RanBP9 Modulates AICD Localization and Transcriptional Activity via Direct Interaction with Tip60
Journal of Alzheimer s Disease·2014· 23 cited
An Intriguing Shift Occurs in the Novel Protein Phosphatase 1 Binding Partner, TCTEX1D4: Evidence of Positive Selection in a Pika Model
PLoS ONE·2013· 6 citedOpen Access
The Nuclear Envelope Protein, LAP1B, Is a Novel Protein Phosphatase 1 Substrate
PLoS ONE·2013· 30 citedOpen Access
“OMICS” of Human Sperm: Profiling Protein Phosphatases
OMICS A Journal of Integrative Biology·2013· 21 cited
Identification of a Novel Complex AβPP:Fe65:PP1 that Regulates AβPP Thr <sup>668</sup> Phosphorylation Levels
Journal of Alzheimer s Disease·2013· 30 cited
Identification and characterization of two distinct PPP1R2 isoforms in human spermatozoa
BMC Cell Biology·2013· 20 citedOpen Access
TCTEX1D4, a novel protein phosphatase 1 interactor: connecting the phosphatase to the microtubule network
Biology Open·2013· 18 citedOpen Access
Protein Phosphatase 1γ Isoforms Linked Interactions in the Brain
Journal of Molecular Neuroscience·2012· 17 cited
Protein Phosphatase 1α Interacting Proteins in the Human Brain
OMICS A Journal of Integrative Biology·2012· 38 citedOpen Access
Identification and characterization of a neuronal enriched novel transcript encoding the previously described p60Fe65 isoform
Journal of Neurochemistry·2011· 7 cited
Wnt Signalling is a Relevant Pathway Contributing to Amyloid Beta-Peptide-Mediated Neuropathology in Alzheimers Disease
CNS & Neurological Disorders - Drug Targets·2010· 22 cited
Retrieval of the Alzheimer's amyloid precursor protein from the endosome to the TGN is S655 phosphorylation state-dependent and retromer-mediated
Molecular Neurodegeneration·2010· 131 citedOpen Access
Progesterone regulates the phosphorylation of protein phosphatases in the brain
Journal of Neuroscience Research·2010· 11 cited
Aβ promotes Alzheimer’s disease‐like cytoskeleton abnormalities with consequences to APP processing in neurons
Journal of Neurochemistry·2010· 61 citedOpen Access
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Frequent Co-authors

Odete A. B. da Cruz e Silva(39), Sandra Rebelo(19), Sandra I. Vieira(15), Margarida Fardilha(14), Ana Gabriela Henriques(13), Sara C. Domingues(12), Patricia T.W. Cohen(6), Mariana Santos(6), Luís Korrodi‐Gregório(6), Paul Greengard(5), Wenjuan Wu(5), Sara L. C. Esteves(5), Ana Paula B. Vintém(4), Srinivasan Vijayaraghavan(3), Filipa Martins(3), Gary D. Smith(2), Hermann Esselmann(2), Jens Wiltfang(2), Sam Gandy(2), T. Alwyn Jones(2)